Aliases for FAR2 Gene
External Ids for FAR2 Gene
Previous HGNC Symbols for FAR2 Gene
Previous GeneCards Identifiers for FAR2 Gene
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
GeneCards Summary for FAR2 Gene
FAR2 (Fatty Acyl-CoA Reductase 2) is a Protein Coding gene. Diseases associated with FAR2 include Fanconi Anemia, Complementation Group B and Zellweger Syndrome. Among its related pathways are Metabolism and Wax biosynthesis. Gene Ontology (GO) annotations related to this gene include NAD binding and coenzyme binding. An important paralog of this gene is FAR1.
UniProtKB/Swiss-Prot Summary for FAR2 Gene
Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates (PubMed:15220348). It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity).