Free for academic non-profit institutions. Other users need a Commercial license
This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
FAR2 (Fatty Acyl-CoA Reductase 2) is a Protein Coding gene. Diseases associated with FAR2 include Fanconi Anemia, Complementation Group B and Zellweger Syndrome. Among its related pathways are Metabolism and Peroxisome. Gene Ontology (GO) annotations related to this gene include NAD binding and coenzyme binding. An important paralog of this gene is FAR1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016491 | oxidoreductase activity | IEA,TAS | -- |
GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity | IEA,IDA | 15220348 |
GO:0102965 | alcohol-forming fatty acyl-CoA reductase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005777 | peroxisome | IBA,ISS | -- |
GO:0005778 | peroxisomal membrane | IEA | -- |
GO:0005779 | integral component of peroxisomal membrane | IDA | 24108123 |
GO:0005782 | peroxisomal matrix | TAS | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
|
|
2 | Peroxisome | ||
3 | Wax biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0010025 | wax biosynthetic process | TAS | -- |
GO:0035336 | long-chain fatty-acyl-CoA metabolic process | IBA,IDA | 15220348 |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
(2E)-Decenoyl-CoA |
|
10018-95-8 |
|
|||
(2E)-Dodecenoyl-CoA |
|
1066-12-2 |
|
|||
(2E)-Hexadecenoyl-CoA |
|
4460-95-1 |
|
|||
(2E)-Octenoyl-CoA |
|
10018-94-7 |
|
|||
(2E)-Tetradecenoyl-CoA |
|
38795-33-4 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FAR2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FAR2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FAR2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Far2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Far2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FAR2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FAR2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FAR2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | FAR2 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5065 30 31 |
|
ManyToMany | |
CG12268 31 |
|
ManyToMany | |||
CG14893 31 |
|
ManyToMany | |||
CG4020 31 |
|
ManyToMany | |||
CG17560 31 |
|
ManyToMany | |||
CG17562 31 |
|
ManyToMany | |||
CG10097 31 |
|
ManyToMany | |||
CG10096 31 |
|
ManyToMany | |||
CG8306 31 |
|
ManyToMany | |||
CG13091 31 |
|
ManyToMany | |||
CG1441 31 |
|
ManyToMany | |||
CG30427 31 |
|
ManyToMany | |||
CG1443 31 |
|
ManyToMany | |||
CG18031 31 |
|
ManyToMany | |||
CG4770 31 |
|
ManyToMany | |||
CG34342 31 |
|
ManyToMany | |||
CG8303 31 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009690 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | fard-1 30 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MS2 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0167600 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
CSA.10130 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762969 | CNV | loss | 21179565 |
esv33168 | CNV | gain | 17666407 |
esv33218 | CNV | gain | 17666407 |
nsv1113470 | CNV | deletion | 24896259 |
nsv437739 | CNV | loss | 16327808 |
nsv477212 | CNV | novel sequence insertion | 20440878 |
nsv819469 | CNV | gain | 19587683 |
nsv951345 | CNV | duplication | 24416366 |
nsv975465 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
fanconi anemia, complementation group b |
|
|
zellweger syndrome |
|
|
amyotrophic lateral sclerosis 1 |
|
|