Aliases for FANCF Gene
External Ids for FANCF Gene
Previous GeneCards Identifiers for FANCF Gene
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]
GeneCards Summary for FANCF Gene
FANCF (FA Complementation Group F) is a Protein Coding gene. Diseases associated with FANCF include Fanconi Anemia, Complementation Group F and Fanconi Anemia, Complementation Group A. Among its related pathways are BRCA1 Pathway and Chks in Checkpoint Regulation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot Summary for FANCF Gene
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).