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Aliases for FANCD2OS Gene

Aliases for FANCD2OS Gene

  • FANCD2 Opposite Strand 2 3 5
  • Fanconi Anemia Group D2 Protein Opposite Strand Transcript Protein 3 4
  • C3orf24 3 4
  • Chromosome 3 Open Reading Frame 24 2
  • FANCD2 Opposite Strand Protein 3

External Ids for FANCD2OS Gene

Previous HGNC Symbols for FANCD2OS Gene

  • C3orf24

Summaries for FANCD2OS Gene

Entrez Gene Summary for FANCD2OS Gene

  • This gene encodes a conserved protein of unknown function. [provided by RefSeq, Jan 2013]

GeneCards Summary for FANCD2OS Gene

FANCD2OS (FANCD2 Opposite Strand) is a Protein Coding gene.

Additional gene information for FANCD2OS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FANCD2OS Gene

Genomics for FANCD2OS Gene

GeneHancer (GH) Regulatory Elements for FANCD2OS Gene

Promoters and enhancers for FANCD2OS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I010108 Promoter 0.5 EPDnew 550.8 +0.2 170 0.1 FANCD2OS GC03M010064
GH03I010109 Promoter 0.5 EPDnew 550.8 +0.1 64 0.1 FANCD2OS GC03M010064
GH03I010024 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.7 +82.1 82087 2.7 CLOCK MLX DMAP1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 FANCD2 CIDECP BRPF1 SETD5 GHRLOS SEC13 BRK1 FANCD2OS CRELD1 CYCSP10
GH03I010247 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -140.9 -140887 3 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000272410 PIR49172 PIR32642 PIR57492 PIR36484 PIR45247 TATDN2 GHRLOS GHRL IRAK2
GH03I009985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.7 +121.2 121207 2.5 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B EMC3-AS1 EMC3 FANCD2 BRPF1 BRK1 GHRLOS RNU6-670P FANCD2OS PRRT3 SETD5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FANCD2OS on UCSC Golden Path with GeneCards custom track

Genomic Locations for FANCD2OS Gene

Genomic Locations for FANCD2OS Gene
chr3:10,081,317-10,108,339
(GRCh38/hg38)
Size:
27,023 bases
Orientation:
Minus strand
chr3:10,123,001-10,149,915
(GRCh37/hg19)

Genomic View for FANCD2OS Gene

Genes around FANCD2OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FANCD2OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FANCD2OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FANCD2OS Gene

Proteins for FANCD2OS Gene

  • Protein details for FANCD2OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PS1-FACOS_HUMAN
    Recommended name:
    FANCD2 opposite strand protein
    Protein Accession:
    Q96PS1

    Protein attributes for FANCD2OS Gene

    Size:
    177 amino acids
    Molecular mass:
    20188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FANCD2OS Gene

Post-translational modifications for FANCD2OS Gene

No Post-translational modifications

Other Protein References for FANCD2OS Gene

No data available for DME Specific Peptides for FANCD2OS Gene

Domains & Families for FANCD2OS Gene

Gene Families for FANCD2OS Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FANCD2OS Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FANCD2OS: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FANCD2OS Gene

Function for FANCD2OS Gene

Phenotypes From GWAS Catalog for FANCD2OS Gene

genes like me logo Genes that share phenotypes with FANCD2OS: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FANCD2OS Gene

Localization for FANCD2OS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FANCD2OS Gene

Pathways & Interactions for FANCD2OS Gene

SuperPathways for FANCD2OS Gene

No Data Available

Interacting Proteins for FANCD2OS Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000429608%0d%0a9606.ENSP00000348704%0d%0a9606.ENSP00000343701%0d%0a
Selected Interacting proteins: ENSP00000429608 for FANCD2OS Gene via STRING

Gene Ontology (GO) - Biological Process for FANCD2OS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FANCD2OS Gene

Drugs & Compounds for FANCD2OS Gene

No Compound Related Data Available

Transcripts for FANCD2OS Gene

Unigene Clusters for FANCD2OS Gene

FANCD2 opposite strand:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FANCD2OS Gene

No ASD Table

Relevant External Links for FANCD2OS Gene

GeneLoc Exon Structure for
FANCD2OS
ECgene alternative splicing isoforms for
FANCD2OS

Expression for FANCD2OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FANCD2OS Gene

mRNA differential expression in normal tissues according to GTEx for FANCD2OS Gene

This gene is overexpressed in Testis (x52.6).

NURSA nuclear receptor signaling pathways regulating expression of FANCD2OS Gene:

FANCD2OS

SOURCE GeneReport for Unigene cluster for FANCD2OS Gene:

Hs.190413
genes like me logo Genes that share expression patterns with FANCD2OS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FANCD2OS Gene

Orthologs for FANCD2OS Gene

This gene was present in the common ancestor of chordates.

Orthologs for FANCD2OS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FANCD2OS 33 34
  • 99.81 (n)
oppossum
(Monodelphis domestica)
Mammalia FANCD2OS 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FANCD2OS 33 34
  • 90.96 (n)
dog
(Canis familiaris)
Mammalia FANCD2OS 33 34
  • 90.02 (n)
rat
(Rattus norvegicus)
Mammalia Fancd2os 33
  • 88.14 (n)
mouse
(Mus musculus)
Mammalia Fancd2os 33 16 34
  • 87.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FANCD2OS 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3ORF24 33
  • 54.83 (n)
FANCD2OS 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
OneToMany
-- 34
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fancd2os 33
  • 60.69 (n)
Species where no ortholog for FANCD2OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FANCD2OS Gene

ENSEMBL:
Gene Tree for FANCD2OS (if available)
TreeFam:
Gene Tree for FANCD2OS (if available)

Paralogs for FANCD2OS Gene

(2) SIMAP similar genes for FANCD2OS Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FANCD2OS: view

No data available for Paralogs for FANCD2OS Gene

Variants for FANCD2OS Gene

Sequence variations from dbSNP and Humsavar for FANCD2OS Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1031051889 uncertain-significance, Fanconi anemia 10,099,072(-) C/T genic_downstream_transcript_variant, intron_variant
rs11716842 benign, Fanconi anemia 10,099,500(-) C/A/T genic_downstream_transcript_variant, intron_variant
rs121917786 pathogenic, Fanconi anemia, complementation group D2 10,090,315(-) G/A/T genic_downstream_transcript_variant, intron_variant
rs145889419 likely-benign, Fanconi anemia 10,098,896(-) G/A genic_downstream_transcript_variant, intron_variant
rs147675860 not-provided, conflicting-interpretations-of-pathogenicity, likely-benign, not specified, Fanconi anemia, not provided 10,087,244(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FANCD2OS Gene

Variant ID Type Subtype PubMed ID
nsv436869 CNV insertion 17901297
nsv436362 CNV deletion 17901297
nsv1121603 CNV deletion 24896259
nsv1073204 CNV deletion 25765185
nsv1013605 CNV loss 25217958
nsv1013567 CNV loss 25217958
esv4117 OTHER complex 18987735
esv3568607 CNV loss 25503493
dgv762e201 CNV deletion 23290073

Variation tolerance for FANCD2OS Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FANCD2OS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FANCD2OS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FANCD2OS Gene

Disorders for FANCD2OS Gene

Additional Disease Information for FANCD2OS

No disorders were found for FANCD2OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FANCD2OS Gene

Publications for FANCD2OS Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies. (PMID: 24755620) Pérez-Palma E … NIA-LOAD/NCRAD Family Study Group (PloS one 2014) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58

Products for FANCD2OS Gene

Sources for FANCD2OS Gene

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