Aliases for FANCC Gene
External Ids for FANCC Gene
Previous HGNC Symbols for FANCC Gene
Previous GeneCards Identifiers for FANCC Gene
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]
GeneCards Summary for FANCC Gene
FANCC (FA Complementation Group C) is a Protein Coding gene. Diseases associated with FANCC include Fanconi Anemia, Complementation Group C and Fanconi Anemia, Complementation Group A. Among its related pathways are DNA Double-Strand Break Repair and Chks in Checkpoint Regulation.
UniProtKB/Swiss-Prot Summary for FANCC Gene
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.