Aliases for FAM98A Gene

Aliases for FAM98A Gene

  • Family With Sequence Similarity 98 Member A 2 3 5
  • Protein FAM98A 3 4
  • Family With Sequence Similarity 98, Member A 2

External Ids for FAM98A Gene

Previous GeneCards Identifiers for FAM98A Gene

  • GC02M033721
  • GC02M033808
  • GC02M033542

Summaries for FAM98A Gene

GeneCards Summary for FAM98A Gene

FAM98A (Family With Sequence Similarity 98 Member A) is a Protein Coding gene. An important paralog of this gene is FAM98B.

UniProtKB/Swiss-Prot Summary for FAM98A Gene

  • Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436).

Additional gene information for FAM98A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM98A Gene

Genomics for FAM98A Gene

GeneHancer (GH) Regulatory Elements for FAM98A Gene

Promoters and enhancers for FAM98A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J033597 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 513 +0.5 482 3.8 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G PHF8 PHB2 ZIC2 REST FAM98A ENSG00000286415 LOC105374455 TTC27 RASGRP3 lnc-RASGRP3-8
GH02J033582 Enhancer 0.8 Ensembl ENCODE 15.2 +17.0 17030 3.9 CTCF REST RAD21 TRIM22 SMC3 HDAC2 ZNF384 ZNF654 ATF4 NFIC FAM98A RASGRP3 lnc-RASGRP3-8
GH02J033491 Enhancer 1 ENCODE dbSUPER 11.4 +103.4 103356 9 RXRA TCF12 SP1 JUND EP300 REST RELA MEF2C TRIM22 POLR2A FAM98A ATP6V0E1P3 ENSG00000237133 HSALNG0014116 lnc-LTBP1-1 RASGRP3
GH02J033602 Enhancer 0.6 Ensembl ENCODE 15.2 -3.6 -3591 2.3 TCF12 CHD7 EP300 POU5F1 ZNF770 ATP6V0E1P3 lnc-RASGRP3-10 FAM98A RASGRP3 HSALNG0014130 ENSG00000286415 LOC105374455
GH02J033607 Enhancer 0.5 ENCODE 17.4 -8.0 -7998 1.9 PBX2 MAFK ZFP64 MEIS2 CHD7 SP1 POU5F1 NANOG POLR2A HSALNG0014130 FAM98A RASGRP3 piR-37097-047 ENSG00000286415 LOC105374455
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM98A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM98A

Top Transcription factor binding sites by QIAGEN in the FAM98A gene promoter:
  • AML1a
  • Bach1
  • c-Myb
  • C/EBPalpha
  • CHOP-10
  • MIF-1
  • Nkx6-1
  • Pax-3
  • Pax-6
  • Zic3

Genomic Locations for FAM98A Gene

Genomic Locations for FAM98A Gene
chr2:33,583,660-33,599,382
(GRCh38/hg38)
Size:
15,723 bases
Orientation:
Minus strand
chr2:33,808,725-33,824,449
(GRCh37/hg19)
Size:
15,725 bases
Orientation:
Minus strand

Genomic View for FAM98A Gene

Genes around FAM98A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM98A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM98A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM98A Gene

Proteins for FAM98A Gene

  • Protein details for FAM98A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCA5-FA98A_HUMAN
    Recommended name:
    Protein FAM98A
    Protein Accession:
    Q8NCA5
    Secondary Accessions:
    • B2RNA2
    • Q9Y3Y6

    Protein attributes for FAM98A Gene

    Size:
    518 amino acids
    Molecular mass:
    55273 Da
    Quaternary structure:
    • Interacts (via N- and C-terminus) with DDX1 (PubMed:28040436). Interacts (via N- and C-terminus) with C14orf166 (PubMed:28040436). Interacts with FAM98B (PubMed:28040436). Interacts with PLEKHM1 (via N- and C-terminus) (By similarity).

neXtProt entry for FAM98A Gene

Post-translational modifications for FAM98A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM98A Gene

No data available for DME Specific Peptides for FAM98A Gene

Domains & Families for FAM98A Gene

Gene Families for FAM98A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM98A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM98A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52744, highly similar to Protein FAM98A (B4DT23_HUMAN)
  • Protein FAM98A (FA98A_HUMAN)
  • FAM98A protein (Q05CT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NCA5

UniProtKB/Swiss-Prot:

FA98A_HUMAN :
  • Belongs to the FAM98 family.
Family:
  • Belongs to the FAM98 family.
genes like me logo Genes that share domains with FAM98A: view

Function for FAM98A Gene

Molecular function for FAM98A Gene

UniProtKB/Swiss-Prot Function:
Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436).

Phenotypes From GWAS Catalog for FAM98A Gene

Gene Ontology (GO) - Molecular Function for FAM98A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008276 protein methyltransferase activity IMP 28040436
genes like me logo Genes that share ontologies with FAM98A: view
genes like me logo Genes that share phenotypes with FAM98A: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM98A Gene

Localization for FAM98A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM98A gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1
lysosome 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM98A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072669 tRNA-splicing ligase complex IBA 21873635
genes like me logo Genes that share ontologies with FAM98A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM98A Gene

Pathways & Interactions for FAM98A Gene

PathCards logo

SuperPathways for FAM98A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM98A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006479 protein methylation IMP 28040436
GO:0008284 positive regulation of cell proliferation IMP 28040436
GO:0010628 positive regulation of gene expression IMP 28040436
GO:0032418 lysosome localization IEA,ISS --
GO:1900029 positive regulation of ruffle assembly IEA,ISS --
genes like me logo Genes that share ontologies with FAM98A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM98A Gene

Drugs & Compounds for FAM98A Gene

No Compound Related Data Available

Transcripts for FAM98A Gene

mRNA/cDNA for FAM98A Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM98A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for FAM98A Gene

GeneLoc Exon Structure for
FAM98A

Expression for FAM98A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM98A Gene

Protein differential expression in normal tissues from HIPED for FAM98A Gene

This gene is overexpressed in Lung (16.8), Bone marrow stromal cell (14.5), and Breast (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM98A Gene



Protein tissue co-expression partners for FAM98A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM98A

SOURCE GeneReport for Unigene cluster for FAM98A Gene:

Hs.468140

mRNA Expression by UniProt/SwissProt for FAM98A Gene:

Q8NCA5-FA98A_HUMAN
Tissue specificity: Expressed strongly in colorectal cancer cells (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).

Evidence on tissue expression from TISSUES for FAM98A Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with FAM98A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM98A Gene

Orthologs for FAM98A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM98A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM98A 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM98A 31 30
  • 94.97 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM98A 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM98A 31 30
  • 92.51 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam98a 30
  • 91.07 (n)
mouse
(Mus musculus)
Mammalia Fam98a 17 31 30
  • 90.36 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM98A 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM98A 31 30
  • 72.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM98A 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488558 30
  • 71.12 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2395 30
zebrafish
(Danio rerio)
Actinopterygii fam98a 31
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011248 30
  • 48.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5913 31 30
  • 46.6 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-322 31
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToMany
Species where no ortholog for FAM98A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM98A Gene

ENSEMBL:
Gene Tree for FAM98A (if available)
TreeFam:
Gene Tree for FAM98A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM98A: view image

Paralogs for FAM98A Gene

Paralogs for FAM98A Gene

(2) SIMAP similar genes for FAM98A Gene using alignment to 6 proteins:

  • FA98A_HUMAN
  • B4DT23_HUMAN
  • C9J3G8_HUMAN
  • E9PH82_HUMAN
  • I6L9E8_HUMAN
  • Q05CT2_HUMAN
genes like me logo Genes that share paralogs with FAM98A: view

Variants for FAM98A Gene

Additional dbSNP identifiers (rs#s) for FAM98A Gene

Variation tolerance for FAM98A Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM98A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM98A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for FAM98A Gene

Disorders for FAM98A Gene

Additional Disease Information for FAM98A

No disorders were found for FAM98A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM98A Gene

Publications for FAM98A Gene

  1. FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. (PMID: 28040436) Akter KA … Senga T (The international journal of biochemistry & cell biology 2017) 3 4 54
  2. A divergent calponin homology (NN-CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins. (PMID: 24257188) Schou KB … Pedersen LB (Bioinformatics (Oxford, England) 2014) 2 3 54
  3. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. (PMID: 19421330) Yang HC … Pan WH (PloS one 2009) 3 41 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion. (PMID: 31519766) Chan CJ … Melançon P (Molecular & cellular proteomics : MCP 2019) 3 54

Products for FAM98A Gene

Sources for FAM98A Gene