Aliases for FAM92B Gene

Aliases for FAM92B Gene

  • Family With Sequence Similarity 92 Member B 2 3 5
  • Protein FAM92B 3 4
  • Family With Sequence Similarity 92, Member B 2

External Ids for FAM92B Gene

Previous GeneCards Identifiers for FAM92B Gene

  • GC16M083690
  • GC16M085131
  • GC16M070884

Summaries for FAM92B Gene

GeneCards Summary for FAM92B Gene

FAM92B (Family With Sequence Similarity 92 Member B) is a Protein Coding gene. An important paralog of this gene is FAM92A.

UniProtKB/Swiss-Prot Summary for FAM92B Gene

  • May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).

Additional gene information for FAM92B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM92B Gene

Genomics for FAM92B Gene

GeneHancer (GH) Regulatory Elements for FAM92B Gene

Promoters and enhancers for FAM92B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM92B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM92B gene promoter:
  • AhR
  • AREB6
  • Brachyury
  • Egr-2
  • FOXO4
  • HTF
  • Lhx3a
  • LHX3b
  • NF-1
  • Roaz

Genomic Locations for FAM92B Gene

Genomic Locations for FAM92B Gene
chr16:85,098,352-85,112,508
(GRCh38/hg38)
Size:
14,157 bases
Orientation:
Minus strand
chr16:85,131,965-85,146,114
(GRCh37/hg19)
Size:
14,150 bases
Orientation:
Minus strand

Genomic View for FAM92B Gene

Genes around FAM92B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM92B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM92B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM92B Gene

Proteins for FAM92B Gene

  • Protein details for FAM92B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTR7-FA92B_HUMAN
    Recommended name:
    Protein FAM92B
    Protein Accession:
    Q6ZTR7
    Secondary Accessions:
    • A0A0D9SG36

    Protein attributes for FAM92B Gene

    Size:
    304 amino acids
    Molecular mass:
    34755 Da
    Quaternary structure:
    • Homodimer (via BAR-like domain) (PubMed:27528616). Heterodimer (via BAR-like domain) with FAM92B (PubMed:27528616). Interacts with CBY1; this interaction is required for targeting FAM92B to centriole (PubMed:27528616).

neXtProt entry for FAM92B Gene

Post-translational modifications for FAM92B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM92B Gene

No data available for DME Specific Peptides for FAM92B Gene

Domains & Families for FAM92B Gene

Gene Families for FAM92B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM92B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM92B Gene

GenScript: Design optimal peptide antigens:
  • Family with sequence similarity 92, member B, isoform CRA_a (D3DUM3_HUMAN)
  • Protein FAM92B (FA92B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZTR7

UniProtKB/Swiss-Prot:

FA92B_HUMAN :
  • The BAR-like domain displays limited similarity to other BAR domains.
  • Belongs to the FAM92 family.
Domain:
  • The BAR-like domain displays limited similarity to other BAR domains.
Family:
  • Belongs to the FAM92 family.
genes like me logo Genes that share domains with FAM92B: view

Function for FAM92B Gene

Molecular function for FAM92B Gene

UniProtKB/Swiss-Prot Function:
May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616).

Phenotypes From GWAS Catalog for FAM92B Gene

Gene Ontology (GO) - Molecular Function for FAM92B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27528616
genes like me logo Genes that share ontologies with FAM92B: view
genes like me logo Genes that share phenotypes with FAM92B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM92B Gene

Localization for FAM92B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM92B Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Note=Extensive colocalization with CBY1 at mother centrioles. {ECO:0000250 UniProtKB:Q3V2J0}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM92B gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 2
mitochondrion 0

Gene Ontology (GO) - Cellular Components for FAM92B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005856 cytoskeleton IEA --
GO:0036064 ciliary basal body IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with FAM92B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM92B Gene

Pathways & Interactions for FAM92B Gene

PathCards logo

SuperPathways for FAM92B Gene

No Data Available

Interacting Proteins for FAM92B Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000443411 for FAM92B Gene via STRING

Gene Ontology (GO) - Biological Process for FAM92B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with FAM92B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM92B Gene

Drugs & Compounds for FAM92B Gene

No Compound Related Data Available

Transcripts for FAM92B Gene

mRNA/cDNA for FAM92B Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM92B Gene

No ASD Table

Relevant External Links for FAM92B Gene

GeneLoc Exon Structure for
FAM92B
ECgene alternative splicing isoforms for
FAM92B

Expression for FAM92B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM92B Gene

mRNA differential expression in normal tissues according to GTEx for FAM92B Gene

This gene is overexpressed in Pituitary (x12.9), Fallopian Tube (x8.1), Brain - Hypothalamus (x5.8), Lung (x4.8), and Cervix - Endocervix (x4.5).

Protein differential expression in normal tissues from HIPED for FAM92B Gene

This gene is overexpressed in Frontal cortex (18.3), Bone marrow mesenchymal stem cell (9.5), and Urinary Bladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM92B Gene



Protein tissue co-expression partners for FAM92B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM92B Gene:

FAM92B

SOURCE GeneReport for Unigene cluster for FAM92B Gene:

Hs.125713

mRNA Expression by UniProt/SwissProt for FAM92B Gene:

Q6ZTR7-FA92B_HUMAN
Tissue specificity: Restricted to certain tissues, most prominently expressed in multicilaited tissues.

Evidence on tissue expression from TISSUES for FAM92B Gene

  • Lung(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with FAM92B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM92B Gene

Orthologs for FAM92B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM92B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM92B 33 32
  • 98.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam92b 17 33 32
  • 83.07 (n)
cow
(Bos Taurus)
Mammalia FAM92B 33 32
  • 81.76 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam92b 32
  • 80.82 (n)
dog
(Canis familiaris)
Mammalia FAM92B 33 32
  • 79.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM92B 33
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM92B 33
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam92b 32
  • 64.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12567 32
fruit fly
(Drosophila melanogaster)
Insecta CG6405 33
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11121 33
  • 29 (a)
OneToMany
Species where no ortholog for FAM92B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM92B Gene

ENSEMBL:
Gene Tree for FAM92B (if available)
TreeFam:
Gene Tree for FAM92B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM92B: view image

Paralogs for FAM92B Gene

Paralogs for FAM92B Gene

(1) SIMAP similar genes for FAM92B Gene using alignment to 2 proteins:

  • FA92B_HUMAN
  • D3DUM3_HUMAN
genes like me logo Genes that share paralogs with FAM92B: view

Variants for FAM92B Gene

Sequence variations from dbSNP and Humsavar for FAM92B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000065261 -- 85,108,191(-) C/T intron_variant
rs1000119533 -- 85,109,989(-) C/T intron_variant
rs1000291687 -- 85,108,204(-) G/C intron_variant
rs1000423872 -- 85,110,120(-) CCC/CC intron_variant
rs1000454778 -- 85,110,773(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM92B Gene

Variant ID Type Subtype PubMed ID
dgv3059n100 CNV gain 25217958
nsv1066002 CNV loss 25217958
nsv1066260 CNV gain 25217958
nsv483044 CNV gain 15286789
nsv573474 CNV loss 21841781

Variation tolerance for FAM92B Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM92B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM92B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM92B Gene

Disorders for FAM92B Gene

Additional Disease Information for FAM92B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM92B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM92B Gene

Publications for FAM92B Gene

  1. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis. (PMID: 27528616) Li FQ … Takemaru KI (Molecular and cellular biology 2016) 2 3 4 56
  2. rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population. (PMID: 19262523) Glas J … Brand S (The American journal of gastroenterology 2009) 3 43 56
  3. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. (PMID: 18580884) Roberts RL … Merriman TR (Genes and immunity 2008) 3 43 56
  4. NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults. (PMID: 21472827) Amre DK … Levy E (Inflammatory bowel diseases 2012) 3 56
  5. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (PMID: 17068223) Duerr RH … Cho JH (Science (New York, N.Y.) 2006) 43 56

Products for FAM92B Gene

Sources for FAM92B Gene