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Aliases for FAM91A1 Gene

Aliases for FAM91A1 Gene

  • Family With Sequence Similarity 91 Member A1 2 3 5
  • Family With Sequence Similarity 91, Member A1 2
  • Skeletal Muscle Cells Re-Entry Induced 3
  • Protein FAM91A1 3

External Ids for FAM91A1 Gene

Previous GeneCards Identifiers for FAM91A1 Gene

  • GC08P124860
  • GC08P120107
  • GC08P124780

Summaries for FAM91A1 Gene

GeneCards Summary for FAM91A1 Gene

FAM91A1 (Family With Sequence Similarity 91 Member A1) is a Protein Coding gene. Among its related pathways are Gastric Cancer Network 2.

Additional gene information for FAM91A1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM91A1 Gene

Genomics for FAM91A1 Gene

GeneHancer (GH) Regulatory Elements for FAM91A1 Gene

Promoters and enhancers for FAM91A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J123767 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662 +0.7 677 3.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 FAM91A1 RNF139-AS1 TRMT12 GC08P123773 PIR45133 GC08P123742
GH08J123394 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 40 -372.6 -372589 3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ATAD2 FAM91A1 DERL1 LOC105375738 ENSG00000254249 FER1L6-AS1 ENSG00000254000 ARF1P3 LOC392268 C8orf76
GH08J124537 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.7 +770.5 770461 3.2 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 TATDN1 NDUFB9 TRMT12 FAM91A1 WASHC5-AS1 WASHC5 NSMCE2 RNF139-AS1 RNF139 LOC105375740
GH08J123155 Enhancer 1.5 Ensembl ENCODE dbSUPER 40.3 -610.9 -610927 3.8 CLOCK DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 PPARGC1A SSRP1 PIR54534 TRM-CAT1-1 FAM91A1 DERL1 LOC105375738 ENSG00000254249 FER1L6-AS1 ENSG00000254000 LOC392268 ARF1P3
GH08J124194 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 33.3 +429.9 429910 8.7 HDGF PKNOX1 ARNT NEUROD1 SIN3A FEZF1 YBX1 ZNF2 ZBTB7B IRF4 TRMT12 FAM91A1 TMEM65 WASHC5 WASHC5-AS1 RNF139-AS1 ZNF572 RNF139 NSMCE2 FER1L6-AS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM91A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM91A1 gene promoter:
  • RSRFC4
  • POU2F1a
  • POU2F1
  • GATA-1
  • CUTL1
  • Ik-2
  • RORalpha2
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for FAM91A1 Gene

Genomic Locations for FAM91A1 Gene
47,014 bases
Plus strand
46,997 bases
Plus strand

Genomic View for FAM91A1 Gene

Genes around FAM91A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM91A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM91A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM91A1 Gene

Proteins for FAM91A1 Gene

  • Protein details for FAM91A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM91A1
    Protein Accession:
    Secondary Accessions:
    • B6YY23
    • Q658T5
    • Q8TE89

    Protein attributes for FAM91A1 Gene

    838 amino acids
    Molecular mass:
    93909 Da
    Quaternary structure:
    • Interacts with golgins GOLGA1 and GOLGA4 and with TBC1D23; Interaction with golgins may be mediated by TBC1D23.
    • Sequence=BAB85063.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM91A1 Gene

Post-translational modifications for FAM91A1 Gene

  • Ubiquitination at isoforms=638
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM91A1 Gene

No data available for DME Specific Peptides for FAM91A1 Gene

Domains & Families for FAM91A1 Gene

Gene Families for FAM91A1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM91A1 Gene


Suggested Antigen Peptide Sequences for FAM91A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM91 family.
  • Belongs to the FAM91 family.
genes like me logo Genes that share domains with FAM91A1: view

Function for FAM91A1 Gene

Phenotypes From GWAS Catalog for FAM91A1 Gene

Gene Ontology (GO) - Molecular Function for FAM91A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29084197
genes like me logo Genes that share ontologies with FAM91A1: view
genes like me logo Genes that share phenotypes with FAM91A1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM91A1 Gene

Localization for FAM91A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM91A1 Gene

Golgi apparatus, trans-Golgi network. Note=Recruitment to the TGN requires the presence of GOLGA1, GOLGA4 and TBC1D23. {ECO:0000269 PubMed:29084197}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM91A1 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM91A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IDA 29084197
genes like me logo Genes that share ontologies with FAM91A1: view

Pathways & Interactions for FAM91A1 Gene

SuperPathways for FAM91A1 Gene

SuperPathway Contained pathways
1 Gastric Cancer Network 2
genes like me logo Genes that share pathways with FAM91A1: view

Pathways by source for FAM91A1 Gene

1 BioSystems pathway for FAM91A1 Gene

Gene Ontology (GO) - Biological Process for FAM91A1 Gene


No data available for SIGNOR curated interactions for FAM91A1 Gene

Drugs & Compounds for FAM91A1 Gene

No Compound Related Data Available

Transcripts for FAM91A1 Gene

mRNA/cDNA for FAM91A1 Gene

Unigene Clusters for FAM91A1 Gene

Family with sequence similarity 91, member A1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM91A1 Gene

No ASD Table

Relevant External Links for FAM91A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM91A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM91A1 Gene

Protein differential expression in normal tissues from HIPED for FAM91A1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM91A1 Gene

Protein tissue co-expression partners for FAM91A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM91A1 Gene:


SOURCE GeneReport for Unigene cluster for FAM91A1 Gene:


Evidence on tissue expression from TISSUES for FAM91A1 Gene

  • Liver(4.2)
  • Lymph node(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with FAM91A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM91A1 Gene

Orthologs for FAM91A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM91A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM91A1 34 33
  • 99.72 (n)
(Canis familiaris)
Mammalia FAM91A1 34 33
  • 93 (n)
(Bos Taurus)
Mammalia FAM91A1 34 33
  • 91.73 (n)
(Ornithorhynchus anatinus)
Mammalia FAM91A1 34
  • 91 (a)
(Monodelphis domestica)
Mammalia FAM91A1 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Fam91a1 33
  • 89.5 (n)
(Mus musculus)
Mammalia D15Ertd621e 34 33
  • 88.73 (n)
Fam91a1 16
(Gallus gallus)
Aves FAM91A1 34 33
  • 81.63 (n)
(Anolis carolinensis)
Reptilia FAM91A1 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam91a1 33
  • 75.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8925 33
(Danio rerio)
Actinopterygii fam91a1 34 33
  • 71.42 (n)
zgc63609 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002874 33
  • 48.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7600 34 33
  • 48.62 (n)
(Caenorhabditis elegans)
Secernentea F33H2.2 34 33
  • 52.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G35220 33
  • 48.63 (n)
(Oryza sativa)
Liliopsida Os01g0303200 33
  • 49.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
-- 34
  • 34 (a)
Species where no ortholog for FAM91A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM91A1 Gene

Gene Tree for FAM91A1 (if available)
Gene Tree for FAM91A1 (if available)
Evolutionary constrained regions (ECRs) for FAM91A1: view image

Paralogs for FAM91A1 Gene

(1) SIMAP similar genes for FAM91A1 Gene using alignment to 6 proteins:

  • F91A1_HUMAN
  • E7ER68_HUMAN
  • G3V120_HUMAN
  • H0YC80_HUMAN
  • Q8N6F3_HUMAN
genes like me logo Genes that share paralogs with FAM91A1: view

No data available for Paralogs for FAM91A1 Gene

Variants for FAM91A1 Gene

Sequence variations from dbSNP and Humsavar for FAM91A1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000056789 -- 123,789,965(+) A/G intron_variant
rs1000099054 -- 123,803,875(+) A/G intron_variant
rs1000225854 -- 123,784,305(+) C/T intron_variant
rs1000274495 -- 123,791,785(+) A/G intron_variant
rs1000355926 -- 123,766,579(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM91A1 Gene

Variant ID Type Subtype PubMed ID
nsv6373 CNV deletion 18451855
nsv831451 CNV gain+loss 17160897
nsv971699 CNV duplication 23825009

Variation tolerance for FAM91A1 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM91A1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM91A1 Gene

Disorders for FAM91A1 Gene

Additional Disease Information for FAM91A1

No disorders were found for FAM91A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM91A1 Gene

Publications for FAM91A1 Gene

  1. TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi. (PMID: 29084197) Shin JJH … Munro S (Nature cell biology 2017) 3 4 58
  2. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 44 58
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for FAM91A1 Gene

  • Biorbyt antibodies for FAM91A1

Sources for FAM91A1 Gene

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