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Aliases for FAM90A1 Gene

Aliases for FAM90A1 Gene

  • Family With Sequence Similarity 90 Member A1 2 3 5
  • Family With Sequence Similarity 90, Member A1 2

External Ids for FAM90A1 Gene

Previous GeneCards Identifiers for FAM90A1 Gene

  • GC12M008266
  • GC12M008373

Summaries for FAM90A1 Gene

Entrez Gene Summary for FAM90A1 Gene

  • FAM90A1 belongs to subfamily I of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007 [PubMed 17684299]).[supplied by OMIM, Oct 2009]

GeneCards Summary for FAM90A1 Gene

FAM90A1 (Family With Sequence Similarity 90 Member A1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is FAM90A26.

Additional gene information for FAM90A1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM90A1 Gene

Genomics for FAM90A1 Gene

GeneHancer (GH) Regulatory Elements for FAM90A1 Gene

Promoters and enhancers for FAM90A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I008227 Promoter 1.5 EPDnew Ensembl 550.8 -0.1 -98 0.8 HDGF HDAC1 E4F1 POLR2A ATF7 PRDM10 IKZF2 ZNF687 L3MBTL2 NRF1 ALG1L10P FAM90A1 LINC02449
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM90A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM90A1 gene promoter:

Genomic Locations for FAM90A1 Gene

Genomic Locations for FAM90A1 Gene
6,444 bases
Minus strand

Genomic View for FAM90A1 Gene

Genes around FAM90A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM90A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM90A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM90A1 Gene

Proteins for FAM90A1 Gene

  • Protein details for FAM90A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM90A1
    Protein Accession:
    Secondary Accessions:
    • D3DUU9
    • Q9NVZ6

    Protein attributes for FAM90A1 Gene

    464 amino acids
    Molecular mass:
    49793 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM90A1 Gene

Post-translational modifications for FAM90A1 Gene

No Post-translational modifications

Other Protein References for FAM90A1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM90A1

No data available for DME Specific Peptides for FAM90A1 Gene

Domains & Families for FAM90A1 Gene

Gene Families for FAM90A1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM90A1 Gene

Suggested Antigen Peptide Sequences for FAM90A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM90 family.
  • Belongs to the FAM90 family.
genes like me logo Genes that share domains with FAM90A1: view

Function for FAM90A1 Gene

Phenotypes From GWAS Catalog for FAM90A1 Gene

Gene Ontology (GO) - Molecular Function for FAM90A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FAM90A1: view
genes like me logo Genes that share phenotypes with FAM90A1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM90A1 Gene

Localization for FAM90A1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM90A1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM90A1 Gene

Pathways & Interactions for FAM90A1 Gene

SuperPathways for FAM90A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM90A1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM90A1 Gene

Drugs & Compounds for FAM90A1 Gene

No Compound Related Data Available

Transcripts for FAM90A1 Gene

mRNA/cDNA for FAM90A1 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM90A1 Gene

Family with sequence similarity 90, member A1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM90A1 Gene

No ASD Table

Relevant External Links for FAM90A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM90A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM90A1 Gene

Protein differential expression in normal tissues from HIPED for FAM90A1 Gene

This gene is overexpressed in Heart (38.1) and Platelet (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM90A1 Gene

Protein tissue co-expression partners for FAM90A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM90A1 Gene:


SOURCE GeneReport for Unigene cluster for FAM90A1 Gene:

genes like me logo Genes that share expression patterns with FAM90A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM90A1 Gene

Orthologs for FAM90A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM90A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM90A1 33 34
  • 98.28 (n)
(Rattus norvegicus)
Mammalia LOC102554431 33
  • 53.95 (n)
(Mus musculus)
Mammalia 4932442L08Rik 34 33
  • 53.06 (n)
C86695 34
  • 26 (a)
Fam90a1b 16
(Canis familiaris)
Mammalia -- 34
  • 35 (a)
-- 34
  • 34 (a)
-- 34
  • 34 (a)
-- 34
  • 33 (a)
(Bos Taurus)
Mammalia -- 34
  • 33 (a)
-- 34
  • 32 (a)
Species where no ortholog for FAM90A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM90A1 Gene

Gene Tree for FAM90A1 (if available)
Gene Tree for FAM90A1 (if available)

Paralogs for FAM90A1 Gene

Paralogs for FAM90A1 Gene Pseudogenes for FAM90A1 Gene

genes like me logo Genes that share paralogs with FAM90A1: view

Variants for FAM90A1 Gene

Sequence variations from dbSNP and Humsavar for FAM90A1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000549683 -- 8,224,086(-) A/G coding_sequence_variant, missense_variant
rs1002502413 -- 8,228,146(-) T/C upstream_transcript_variant
rs1002784176 -- 8,227,800(-) G/A/T upstream_transcript_variant
rs1003511059 -- 8,226,576(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1003794091 -- 8,226,249(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM90A1 Gene

Variant ID Type Subtype PubMed ID
nsv973015 CNV duplication 23825009
nsv952794 CNV deletion 24416366
nsv8899 CNV gain+loss 18304495
nsv826226 CNV gain 20364138
nsv820442 CNV duplication 20802225
nsv557339 CNV loss 21841781
nsv557338 CNV gain 21841781
nsv557337 CNV loss 21841781
nsv557336 CNV loss 21841781
nsv514677 CNV gain 21397061
nsv433419 CNV gain 18776910
nsv428270 CNV gain 18775914
nsv1159958 CNV duplication 26073780
nsv1159957 CNV duplication 26073780
esv995004 CNV gain 20482838
esv29886 CNV gain+loss 19812545
esv2871568 CNV duplication 24192839
esv2760766 CNV gain 21179565
esv2760237 CNV gain 21179565
esv2759877 CNV gain+loss 17122850
esv2523633 CNV loss 19546169
esv1001803 CNV insertion 20482838
dgv247e214 CNV gain 21293372
dgv2340n54 CNV loss 21841781
dgv2339n54 CNV gain 21841781
dgv1360n100 CNV gain 25217958
dgv1359n100 CNV gain 25217958
dgv1358n100 CNV gain 25217958

Variation tolerance for FAM90A1 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.91; 96.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM90A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM90A1 Gene

Disorders for FAM90A1 Gene

Additional Disease Information for FAM90A1

No disorders were found for FAM90A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM90A1 Gene

Publications for FAM90A1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N … Roth FP (Molecular systems biology 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for FAM90A1 Gene

Sources for FAM90A1 Gene

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