Aliases for FAM89B Gene

Aliases for FAM89B Gene

  • Family With Sequence Similarity 89 Member B 2 3 5
  • Mammary Tumor Virus Receptor Homolog 1 2 3
  • Leucine Repeat Adapter Protein 25 3 4
  • Leucine Repeat Adaptor Protein 25 2 3
  • Family With Sequence Similarity 89, Member B 2
  • Protein FAM89B 3
  • LRAP25 3
  • Lrap25 4
  • MTVR1 3
  • MTVR 3

External Ids for FAM89B Gene

Previous GeneCards Identifiers for FAM89B Gene

  • GC11P065097
  • GC11P065339
  • GC11P061667

Summaries for FAM89B Gene

GeneCards Summary for FAM89B Gene

FAM89B (Family With Sequence Similarity 89 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription corepressor binding. An important paralog of this gene is FAM89A.

UniProtKB/Swiss-Prot Summary for FAM89B Gene

  • Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.

Additional gene information for FAM89B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM89B Gene

Genomics for FAM89B Gene

GeneHancer (GH) Regulatory Elements for FAM89B Gene

Promoters and enhancers for FAM89B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J065567 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +1.6 1589 12.5 SIN3A ZNF24 SP1 ZBTB40 CTCF SIX5 ZBTB6 MLX RBPJ SMARCE1 EHBP1L1 ZNRD2 FAM89B lnc-LTBP3-4 SF1 POLA2 PCNX3 KAT5 RELA EIF1AD
GH11J065636 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 +68.3 68333 8.2 SP1 CTCF RBPJ SMARCE1 POLR2A NR2F1 NR2F6 MYC ETV6 L3MBTL2 SIPA1 RBM14 EHBP1L1 RBM4 KCNK7 RNASEH2C SF3B2 MAP3K11 SF1 EIF1AD
GH11J065609 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.6 +41.7 41650 8.5 E2F8 SIN3A SP1 ZBTB40 SIX5 ZBTB6 FOXA1 RBPJ POLR2A NR2F6 PCNX3 MAP3K11 KAT5 SF1 ATG2A ENSG00000254855 SF3B2 EIF1AD ENSG00000254461 SART1
GH11J065811 Enhancer 0.5 ENCODE 10.2 +239.9 239858 2 ATF1 PKNOX1 EBF1 IKZF1 CEBPG PRDM6 SNX32 CTSW MAP3K11 OVOL1 AP5B1 CFL1 PCNX3 FIBP CCDC85B SART1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM89B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM89B gene promoter:
  • C/EBPalpha
  • E2F
  • E2F-1
  • FOXO3
  • GATA-2
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • p53
  • Spz1

Genomic Locations for FAM89B Gene

Genomic Locations for FAM89B Gene
chr11:65,572,349-65,574,198
(GRCh38/hg38)
Size:
1,850 bases
Orientation:
Plus strand
chr11:65,339,820-65,341,669
(GRCh37/hg19)
Size:
1,850 bases
Orientation:
Plus strand

Genomic View for FAM89B Gene

Genes around FAM89B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM89B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM89B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM89B Gene

Proteins for FAM89B Gene

  • Protein details for FAM89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5H3-LRA25_HUMAN
    Recommended name:
    Leucine repeat adapter protein 25
    Protein Accession:
    Q8N5H3
    Secondary Accessions:
    • E9PB01
    • E9PL72
    • Q6PJ27

    Protein attributes for FAM89B Gene

    Size:
    189 amino acids
    Molecular mass:
    20147 Da
    Quaternary structure:
    • Interacts with SKI. Interacts (via LRR repeat) with CDC42BPA (via AGC-kinase C-terminal domain), CDC42BPB (via AGC-kinase C-terminal domain) and LIMK1 (via LIM zinc-binding domains). Forms a tripartite complex with CDC42BPA, CDC42BPB and LIMK1.

    Alternative splice isoforms for FAM89B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM89B Gene

Post-translational modifications for FAM89B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM89B Gene

No data available for DME Specific Peptides for FAM89B Gene

Domains & Families for FAM89B Gene

Gene Families for FAM89B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM89B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM89B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM89B (FA89B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N5H3

UniProtKB/Swiss-Prot:

LRA25_HUMAN :
  • Belongs to the FAM89 family.
Family:
  • Belongs to the FAM89 family.
genes like me logo Genes that share domains with FAM89B: view

Function for FAM89B Gene

Molecular function for FAM89B Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.

Phenotypes From GWAS Catalog for FAM89B Gene

Gene Ontology (GO) - Molecular Function for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001222 transcription corepressor binding ISS --
genes like me logo Genes that share ontologies with FAM89B: view
genes like me logo Genes that share phenotypes with FAM89B: view

Animal Model Products

CRISPR Products

miRNA for FAM89B Gene

miRTarBase miRNAs that target FAM89B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM89B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89B Gene

Localization for FAM89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM89B Gene

Isoform 3: Cytoplasm. Cell projection, lamellipodium. Note=Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium. {ECO:0000250 UniProtKB:Q9QUI1}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM89B gene
Compartment Confidence
extracellular 1
peroxisome 1
nucleus 1
cytosol 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0030027 lamellipodium ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with FAM89B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM89B Gene

Pathways & Interactions for FAM89B Gene

PathCards logo

SuperPathways for FAM89B Gene

No Data Available

Interacting Proteins for FAM89B Gene

Selected Interacting proteins: Q8N5H3-LRA25_HUMAN for FAM89B Gene via IID

Symbol External ID(s) Details
MOV10
SEPTIN8

Gene Ontology (GO) - Biological Process for FAM89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030010 establishment of cell polarity IEA,ISS --
GO:0030335 positive regulation of cell migration ISS,IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS,IEA --
GO:0060392 negative regulation of SMAD protein signal transduction IEA,ISS --
genes like me logo Genes that share ontologies with FAM89B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM89B Gene

Drugs & Compounds for FAM89B Gene

No Compound Related Data Available

Transcripts for FAM89B Gene

mRNA/cDNA for FAM89B Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM89B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM89B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e
SP1:
SP2: -
SP3: - -

Relevant External Links for FAM89B Gene

GeneLoc Exon Structure for
FAM89B
ECgene alternative splicing isoforms for
FAM89B

Expression for FAM89B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM89B Gene

Protein differential expression in normal tissues from HIPED for FAM89B Gene

This gene is overexpressed in Heart (28.8), Peripheral blood mononuclear cells (22.9), and Fetal Brain (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM89B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM89B Gene:

FAM89B

SOURCE GeneReport for Unigene cluster for FAM89B Gene:

Hs.731854

Evidence on tissue expression from TISSUES for FAM89B Gene

  • Lung(4.4)
  • Nervous system(4.3)
  • Liver(4.2)
  • Muscle(2.8)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with FAM89B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM89B Gene

Orthologs for FAM89B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM89B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM89B 33 32
  • 97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MGC140823 33
  • 94 (a)
OneToOne
FAM89B 32
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Fam89b 17 33 32
  • 88.36 (n)
dog
(Canis familiaris)
Mammalia FAM89B 33 32
  • 88.36 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam89b 32
  • 87.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53407 32
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7511 32
zebrafish
(Danio rerio)
Actinopterygii LOC100151239 32
  • 61.45 (n)
fam89b 33
  • 53 (a)
OneToOne
Dr.18883 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3539 32
Species where no ortholog for FAM89B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM89B Gene

ENSEMBL:
Gene Tree for FAM89B (if available)
TreeFam:
Gene Tree for FAM89B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM89B: view image

Paralogs for FAM89B Gene

Paralogs for FAM89B Gene

(1) SIMAP similar genes for FAM89B Gene using alignment to 1 proteins:

  • FA89B_HUMAN
genes like me logo Genes that share paralogs with FAM89B: view

Variants for FAM89B Gene

Sequence variations from dbSNP and Humsavar for FAM89B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000708681 -- 65,573,301(+) GGGGCGGGGC/GGGGC/GGGGCGGGGCGGGGC intron_variant
rs1001877977 -- 65,573,746(+) C/G 3_prime_UTR_variant
rs1001940599 -- 65,574,159(+) G/A 3_prime_UTR_variant
rs1003738204 -- 65,572,311(+) G/C upstream_transcript_variant
rs1005296280 -- 65,571,205(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM89B Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
nsv1069595 CNV deletion 25765185
nsv1069596 CNV deletion 25765185
nsv1126297 CNV deletion 24896259
nsv951018 CNV deletion 24416366

Variation tolerance for FAM89B Gene

Gene Damage Index Score: 0.53; 11.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM89B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM89B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89B Gene

Disorders for FAM89B Gene

Additional Disease Information for FAM89B

No disorders were found for FAM89B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM89B Gene

Publications for FAM89B Gene

  1. Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. (PMID: 25107909) Lee IC … Tan I (The Journal of biological chemistry 2014) 2 3 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Identification of human homologues of the mouse mammary tumor virus receptor. (PMID: 11958456) Stewart AF (Archives of virology 2002) 3 23 56
  4. Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins. (PMID: 10512749) Sakuma-Takagi M … Kurihara T (Biochemical and biophysical research communications 1999) 2 3 56
  5. A novel membrane protein is a mouse mammary tumor virus receptor. (PMID: 9525630) Golovkina TV … Ross SR (Journal of virology 1998) 2 3 56

Products for FAM89B Gene

Sources for FAM89B Gene