Aliases for FAM89B Gene
External Ids for FAM89B Gene
Previous GeneCards Identifiers for FAM89B Gene
GeneCards Summary for FAM89B Gene
FAM89B (Family With Sequence Similarity 89 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription corepressor binding. An important paralog of this gene is FAM89A.
UniProtKB/Swiss-Prot for FAM89B Gene
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.