Aliases for FAM89A Gene

Aliases for FAM89A Gene

  • Family With Sequence Similarity 89 Member A 2 3 5
  • Protein FAM89A 3 4
  • C1orf153 3 4
  • Family With Sequence Similarity 89, Member A 2
  • Chromosome 1 Open Reading Frame 153 2

External Ids for FAM89A Gene

Previous HGNC Symbols for FAM89A Gene

  • C1orf153

Previous GeneCards Identifiers for FAM89A Gene

  • GC01M227463
  • GC01M229221
  • GC01M231154
  • GC01M201638

Summaries for FAM89A Gene

GeneCards Summary for FAM89A Gene

FAM89A (Family With Sequence Similarity 89 Member A) is a Protein Coding gene. Diseases associated with FAM89A include Childhood Absence Epilepsy. An important paralog of this gene is FAM89B.

Additional gene information for FAM89A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM89A Gene

Genomics for FAM89A Gene

GeneHancer (GH) Regulatory Elements for FAM89A Gene

Promoters and enhancers for FAM89A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM89A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM89A gene promoter:
  • C/EBPalpha
  • CHOP-10
  • Egr-2
  • Egr-3
  • FOXL1
  • FOXO4
  • Gfi-1
  • IRF-7A
  • POU2F1
  • POU2F1a

Genomic Locations for FAM89A Gene

Genomic Locations for FAM89A Gene
chr1:231,018,958-231,040,254
(GRCh38/hg38)
Size:
21,297 bases
Orientation:
Minus strand
chr1:231,154,704-231,175,995
(GRCh37/hg19)
Size:
21,292 bases
Orientation:
Minus strand

Genomic View for FAM89A Gene

Genes around FAM89A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM89A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM89A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM89A Gene

Proteins for FAM89A Gene

  • Protein details for FAM89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GI7-FA89A_HUMAN
    Recommended name:
    Protein FAM89A
    Protein Accession:
    Q96GI7

    Protein attributes for FAM89A Gene

    Size:
    184 amino acids
    Molecular mass:
    19569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM89A Gene

Post-translational modifications for FAM89A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM89A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM89A Gene

Domains & Families for FAM89A Gene

Gene Families for FAM89A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM89A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM89A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM89A (FA89A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96GI7

UniProtKB/Swiss-Prot:

FA89A_HUMAN :
  • Belongs to the FAM89 family.
Family:
  • Belongs to the FAM89 family.
genes like me logo Genes that share domains with FAM89A: view

Function for FAM89A Gene

Phenotypes From GWAS Catalog for FAM89A Gene

genes like me logo Genes that share phenotypes with FAM89A: view

Animal Model Products

CRISPR Products

miRNA for FAM89A Gene

miRTarBase miRNAs that target FAM89A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM89A Gene

Localization for FAM89A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM89A gene
Compartment Confidence
mitochondrion 2
nucleus 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM89A Gene

Pathways & Interactions for FAM89A Gene

PathCards logo

SuperPathways for FAM89A Gene

No Data Available

Interacting Proteins for FAM89A Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000355614 Q96GI7-FA89A_HUMAN for FAM89A Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM89A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM89A Gene

Drugs & Compounds for FAM89A Gene

No Compound Related Data Available

Transcripts for FAM89A Gene

mRNA/cDNA for FAM89A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(109) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM89A Gene

No ASD Table

Relevant External Links for FAM89A Gene

GeneLoc Exon Structure for
FAM89A
ECgene alternative splicing isoforms for
FAM89A

Expression for FAM89A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM89A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM89A Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.5) and Adipose - Subcutaneous (x4.2).

Protein differential expression in normal tissues from HIPED for FAM89A Gene

This gene is overexpressed in Pancreas (54.2), Adrenal (8.1), and Placenta (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM89A Gene



Protein tissue co-expression partners for FAM89A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM89A Gene:

FAM89A

SOURCE GeneReport for Unigene cluster for FAM89A Gene:

Hs.38516
genes like me logo Genes that share expression patterns with FAM89A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM89A Gene

Orthologs for FAM89A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM89A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM89A 32
  • 99.82 (n)
ptr-mir-1182 33
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM89A 33 32
  • 88.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM89A 33 32
  • 87.69 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam89a 17 33 32
  • 85.74 (n)
rat
(Rattus norvegicus)
Mammalia Fam89a 32
  • 85.23 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM89A 33
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM89A 33
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam89a 32
  • 65.38 (n)
zebrafish
(Danio rerio)
Actinopterygii fam89a 33 32
  • 68.85 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14120 32
Species where no ortholog for FAM89A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM89A Gene

ENSEMBL:
Gene Tree for FAM89A (if available)
TreeFam:
Gene Tree for FAM89A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM89A: view image

Paralogs for FAM89A Gene

Paralogs for FAM89A Gene

(1) SIMAP similar genes for FAM89A Gene using alignment to 1 proteins:

  • FA89A_HUMAN
genes like me logo Genes that share paralogs with FAM89A: view

Variants for FAM89A Gene

Sequence variations from dbSNP and Humsavar for FAM89A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000167847 -- 231,026,206(-) C/T intron_variant
rs1000278930 -- 231,037,726(-) C/T intron_variant
rs1000323767 -- 231,026,852(-) G/A intron_variant
rs1000364900 -- 231,032,205(-) T/C intron_variant
rs1000551751 -- 231,024,794(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM89A Gene

Variant ID Type Subtype PubMed ID
esv3589093 CNV gain 21293372
nsv1000488 CNV gain 25217958
nsv1011066 CNV gain 25217958
nsv1068593 CNV deletion 25765185
nsv1121792 CNV deletion 24896259
nsv945366 CNV duplication 23825009

Variation tolerance for FAM89A Gene

Gene Damage Index Score: 1.01; 20.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM89A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM89A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM89A Gene

Disorders for FAM89A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM89A Gene - From: DISEASES

Disorder Aliases PubMed IDs
childhood absence epilepsy
  • absence seizure
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM89A

genes like me logo Genes that share disorders with FAM89A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM89A Gene

Publications for FAM89A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 56

Products for FAM89A Gene

Sources for FAM89A Gene