Aliases for FAM86B1 Gene

Aliases for FAM86B1 Gene

  • Family With Sequence Similarity 86 Member B1 2 3 5
  • Putative Protein N-Methyltransferase FAM86B1 3 4
  • Family With Sequence Similarity 86, Member B1 2
  • Protein FAM86B1 3
  • EC 2.1.1.- 4
  • MGC16279 2
  • FAM86B1 5

External Ids for FAM86B1 Gene

Previous GeneCards Identifiers for FAM86B1 Gene

  • GC08M012079
  • GC08M012039

Summaries for FAM86B1 Gene

GeneCards Summary for FAM86B1 Gene

FAM86B1 (Family With Sequence Similarity 86 Member B1) is a Protein Coding gene. Diseases associated with FAM86B1 include Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is FAM86B2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM86B1 Gene

Genomics for FAM86B1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM86B1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM86B1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM86B1

Top Transcription factor binding sites by QIAGEN in the FAM86B1 gene promoter:
  • AML1a
  • AP-4
  • HNF-4alpha1
  • HNF-4alpha2
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Pax-5
  • RORalpha1
  • STAT3

Genomic Locations for FAM86B1 Gene

Latest Assembly
chr8:12,182,096-12,195,436
(GRCh38/hg38)
Size:
13,341 bases
Orientation:
Minus strand

Previous Assembly
chr8:12,039,615-12,051,642
(GRCh37/hg19 by Entrez Gene)
Size:
12,028 bases
Orientation:
Minus strand

chr8:12,039,605-12,051,642
(GRCh37/hg19 by Ensembl)
Size:
12,038 bases
Orientation:
Minus strand

Genomic View for FAM86B1 Gene

Genes around FAM86B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM86B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM86B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM86B1 Gene

Proteins for FAM86B1 Gene

  • Protein details for FAM86B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7N1-F86B1_HUMAN
    Recommended name:
    Putative protein N-methyltransferase FAM86B1
    Protein Accession:
    Q8N7N1

    Protein attributes for FAM86B1 Gene

    Size:
    296 amino acids
    Molecular mass:
    32865 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM86B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM86B1 Gene

Post-translational modifications for FAM86B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM86B1 Gene

Domains & Families for FAM86B1 Gene

Gene Families for FAM86B1 Gene

Protein Domains for FAM86B1 Gene

Suggested Antigen Peptide Sequences for FAM86B1 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM86B1 (F86B1_HUMAN)
  • FAM86B1 protein (Q4KMP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N7N1

UniProtKB/Swiss-Prot:

F86B1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.
genes like me logo Genes that share domains with FAM86B1: view

Function for FAM86B1 Gene

Enzyme Numbers (IUBMB) for FAM86B1 Gene

Phenotypes From GWAS Catalog for FAM86B1 Gene

Gene Ontology (GO) - Molecular Function for FAM86B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FAM86B1: view
genes like me logo Genes that share phenotypes with FAM86B1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM86B1

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM86B1 Gene

Localization for FAM86B1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FAM86B1 Gene

Pathways & Interactions for FAM86B1 Gene

PathCards logo

SuperPathways for FAM86B1 Gene

No Data Available

Interacting Proteins for FAM86B1 Gene

Gene Ontology (GO) - Biological Process for FAM86B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with FAM86B1: view

No data available for Pathways by source and SIGNOR curated interactions for FAM86B1 Gene

Drugs & Compounds for FAM86B1 Gene

No Compound Related Data Available

Transcripts for FAM86B1 Gene

mRNA/cDNA for FAM86B1 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM86B1

Alternative Splicing Database (ASD) splice patterns (SP) for FAM86B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -
SP2:

Relevant External Links for FAM86B1 Gene

GeneLoc Exon Structure for
FAM86B1

Expression for FAM86B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM86B1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM86B1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM86B1

SOURCE GeneReport for Unigene cluster for FAM86B1 Gene:

Hs.675799
genes like me logo Genes that share expression patterns with FAM86B1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM86B1 Gene

Orthologs for FAM86B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM86B1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 81 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia FAM86A 30
  • 65 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Fam86 30
  • 61 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 59 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 58 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 57 (a)
OneToMany
Chicken
(Gallus gallus)
Aves FAM86A 30
  • 46 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 47 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii fam86a 30
  • 40 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7889 30
  • 22 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea R08D7.4 30
  • 20 (a)
OneToMany
Species where no ortholog for FAM86B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for FAM86B1 Gene

ENSEMBL:
Gene Tree for FAM86B1 (if available)
TreeFam:
Gene Tree for FAM86B1 (if available)
Alliance of Genome Resources:
Additional Orthologs for FAM86B1

Paralogs for FAM86B1 Gene

Paralogs for FAM86B1 Gene

(4) SIMAP similar genes for FAM86B1 Gene using alignment to 15 proteins:

  • F86B1_HUMAN
  • E9PLC7_HUMAN
  • E9PLW5_HUMAN
  • E9PM45_HUMAN
  • E9PN63_HUMAN
  • E9PNH4_HUMAN
  • E9PRJ7_HUMAN
  • F6QN85_HUMAN
  • F6TTG8_HUMAN
  • H0YD24_HUMAN
  • H0YDM8_HUMAN
  • H9XFB3_HUMAN
  • Q4KMP3_HUMAN
  • R4GN25_HUMAN
  • R4GNF6_HUMAN
genes like me logo Genes that share paralogs with FAM86B1: view

Variants for FAM86B1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM86B1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM86B1 Gene

Variant ID Type Subtype PubMed ID
dgv1270e199 CNV deletion 23128226
dgv154e203 CNV gain+loss 21179565
dgv244e55 CNV gain 17911159
dgv27n31 CNV gain 19718026
dgv7015n100 CNV gain 25217958
dgv7016n100 CNV gain 25217958
dgv7017n100 CNV gain 25217958
dgv7018n100 CNV gain+loss 25217958
dgv7019n100 CNV gain 25217958
dgv7020n100 CNV loss 25217958
dgv7021n100 CNV loss 25217958
dgv7025n100 CNV gain 25217958
dgv7026n100 CNV gain+loss 25217958
esv22986 CNV gain+loss 19812545
esv2736614 CNV deletion 23290073
esv2759593 CNV gain+loss 17122850
nsv1034132 CNV gain 25217958
nsv1077519 CNV duplication 25765185
nsv1139930 CNV duplication 24896259
nsv428195 CNV gain 18775914
nsv516685 CNV gain+loss 19592680
nsv8288 CNV gain+loss 18304495
nsv951104 CNV deletion 24416366
nsv967565 CNV duplication 23825009

Variation tolerance for FAM86B1 Gene

Gene Damage Index Score: 4.56; 65.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM86B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM86B1
Leiden Open Variation Database (LOVD)
FAM86B1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM86B1 Gene

Disorders for FAM86B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM86B1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM86B1

genes like me logo Genes that share disorders with FAM86B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM86B1 Gene

Publications for FAM86B1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P … Coulombe B (PLoS genetics 2013) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for FAM86B1 Gene

Sources for FAM86B1 Gene