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Aliases for FAM84B Gene

Aliases for FAM84B Gene

  • Family With Sequence Similarity 84 Member B 2 3 5
  • Breast Cancer Membrane-Associated Protein 101 2 3
  • Breast Cancer Membrane Protein 101 3 4
  • Neurological/Sensory 2 2 3
  • BCMP101 3 4
  • NSE2 3 4
  • Family With Sequence Similarity 84, Member B 2
  • Protein FAM84B 3
  • Protein NSE2 4

External Ids for FAM84B Gene

Previous GeneCards Identifiers for FAM84B Gene

  • GC08M127634
  • GC08M122881
  • GC08M127564
  • GC08M126612
  • GC08M126614
  • GC08M126616
  • GC08M126625
  • GC08M126646
  • GC08M126648
  • GC08M126650
  • GC08M126862

Summaries for FAM84B Gene

GeneCards Summary for FAM84B Gene

FAM84B (Family With Sequence Similarity 84 Member B) is a Protein Coding gene. An important paralog of this gene is FAM84A.

Additional gene information for FAM84B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM84B Gene

Genomics for FAM84B Gene

GeneHancer (GH) Regulatory Elements for FAM84B Gene

Promoters and enhancers for FAM84B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J126553 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 657.2 +2.1 2055 6.1 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZBTB7B FAM84B LOC105375751 PCAT1
GH08J126432 Enhancer 1.3 FANTOM5 Ensembl ENCODE 56 +123.7 123671 3.6 PKNOX1 NFIB BRCA1 RFX5 FOS RCOR1 SMARCC1 USF2 CEBPB NR2F2 FAM84B ENSG00000253427 LOC101927657
GH08J126824 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -268.4 -268443 5.7 PKNOX1 SIN3A BRCA1 RAD21 RFX5 YY1 ZNF143 RCOR1 FOS ZNF654 FAM84B CASC11 MYC GC08P126836 LOC105375753 RNU11-4P PCAT1
GH08J126578 Enhancer 1 Ensembl ENCODE dbSUPER 11.9 -21.5 -21494 2.1 PKNOX1 MAZ RFX1 DPF2 BMI1 ZNF217 SP1 CTBP1 CTBP2 FOXP2 FAM84B ENSG00000253543 PIR61718 PCAT1 LOC105375751
GH08J126510 Enhancer 0.8 ENCODE 11.7 +48.0 47967 0.2 HDGF PKNOX1 FOXA2 BMI1 RAD21 YY1 ETS1 ZNF207 ZNF143 THAP11 FAM84B LOC105375750 PCAT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM84B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM84B gene promoter:
  • oct-B3
  • IRF-2
  • Oct-B1
  • oct-B2
  • AREB6
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for FAM84B Gene

Genomic Locations for FAM84B Gene
chr8:126,552,438-126,558,478
(GRCh38/hg38)
Size:
6,041 bases
Orientation:
Minus strand
chr8:127,564,683-127,570,711
(GRCh37/hg19)
Size:
6,029 bases
Orientation:
Minus strand

Genomic View for FAM84B Gene

Genes around FAM84B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM84B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM84B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM84B Gene

Proteins for FAM84B Gene

  • Protein details for FAM84B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KN1-FA84B_HUMAN
    Recommended name:
    Protein FAM84B
    Protein Accession:
    Q96KN1

    Protein attributes for FAM84B Gene

    Size:
    310 amino acids
    Molecular mass:
    34474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM84B Gene

Post-translational modifications for FAM84B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM84B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM84B Gene

Domains & Families for FAM84B Gene

Gene Families for FAM84B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM84B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM84B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KN1

UniProtKB/Swiss-Prot:

FA84B_HUMAN :
  • Belongs to the FAM84 family.
Family:
  • Belongs to the FAM84 family.
genes like me logo Genes that share domains with FAM84B: view

Function for FAM84B Gene

Phenotypes From GWAS Catalog for FAM84B Gene

Gene Ontology (GO) - Molecular Function for FAM84B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12477722
genes like me logo Genes that share ontologies with FAM84B: view
genes like me logo Genes that share phenotypes with FAM84B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM84B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM84B Gene

Localization for FAM84B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM84B gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM84B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12477722
GO:0005886 plasma membrane IDA 12477722
genes like me logo Genes that share ontologies with FAM84B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM84B Gene

Pathways & Interactions for FAM84B Gene

SuperPathways for FAM84B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM84B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM84B Gene

Drugs & Compounds for FAM84B Gene

No Compound Related Data Available

Transcripts for FAM84B Gene

mRNA/cDNA for FAM84B Gene

Unigene Clusters for FAM84B Gene

Family with sequence similarity 84, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM84B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM84B Gene

No ASD Table

Relevant External Links for FAM84B Gene

GeneLoc Exon Structure for
FAM84B
ECgene alternative splicing isoforms for
FAM84B

Expression for FAM84B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM84B Gene

Protein differential expression in normal tissues from HIPED for FAM84B Gene

This gene is overexpressed in Salivary gland (27.3), Stomach (9.9), and Breast (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM84B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM84B Gene:

FAM84B

SOURCE GeneReport for Unigene cluster for FAM84B Gene:

Hs.741352

mRNA Expression by UniProt/SwissProt for FAM84B Gene:

Q96KN1-FA84B_HUMAN
Tissue specificity: Expressed in esophageal squamous cell carcinomas.

Evidence on tissue expression from TISSUES for FAM84B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FAM84B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM84B Gene

Orthologs for FAM84B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM84B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM84B 34 33
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM84B 34 33
  • 93.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM84B 34 33
  • 89.74 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam84b 16 34 33
  • 86.88 (n)
rat
(Rattus norvegicus)
Mammalia Fam84b 33
  • 86.13 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM84B 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM84B 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM84B 34 33
  • 77.86 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM84B 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733578 33
  • 73.02 (n)
zebrafish
(Danio rerio)
Actinopterygii fam84b 34 33
  • 67.18 (n)
OneToMany
FAM84B (2 of 2) 34
  • 61 (a)
OneToMany
Species where no ortholog for FAM84B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM84B Gene

ENSEMBL:
Gene Tree for FAM84B (if available)
TreeFam:
Gene Tree for FAM84B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM84B: view image

Paralogs for FAM84B Gene

Paralogs for FAM84B Gene

(1) SIMAP similar genes for FAM84B Gene using alignment to 1 proteins:

  • FA84B_HUMAN
genes like me logo Genes that share paralogs with FAM84B: view

Variants for FAM84B Gene

Sequence variations from dbSNP and Humsavar for FAM84B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000135662 -- 126,552,183(-) G/T downstream_transcript_variant
rs1000238845 -- 126,557,169(-) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000287982 -- 126,556,702(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000505314 -- 126,551,940(-) C/T downstream_transcript_variant
rs1001581450 -- 126,558,659(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM84B Gene

Variant ID Type Subtype PubMed ID
esv2737545 CNV deletion 23290073
nsv499795 OTHER inversion 21111241
nsv7419 OTHER inversion 18451855

Variation tolerance for FAM84B Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM84B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM84B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM84B Gene

Disorders for FAM84B Gene

Additional Disease Information for FAM84B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM84B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM84B Gene

Publications for FAM84B Gene

  1. Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer. (PMID: 20158306) White KL … Goode EL (Twin research and human genetics : the official journal of the International Society for Twin Studies 2010) 3 44 58
  2. Evaluation of the 8q24 prostate cancer risk locus and MYC expression. (PMID: 19549893) Pomerantz MM … Freedman ML (Cancer research 2009) 3 44 58
  3. Negative implication of C-MYC as an amplification target in esophageal cancer. (PMID: 16490593) Huang XP … Liang QW (Cancer genetics and cytogenetics 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. (PMID: 12477722) Adam PJ … Terrett JA (The Journal of biological chemistry 2003) 2 3 58

Products for FAM84B Gene

Sources for FAM84B Gene

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