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Aliases for FAM84A Gene

Aliases for FAM84A Gene

  • Family With Sequence Similarity 84 Member A 2 3 5
  • Neurologic Sensory Protein 1 3 4
  • Neurological/Sensory 1 2 3
  • NSE1 3 4
  • Family With Sequence Similarity 84, Member A 2
  • Protein FAM84A 3
  • PP11517 3

External Ids for FAM84A Gene

Previous GeneCards Identifiers for FAM84A Gene

  • GC02P014724
  • GC02P014773

Summaries for FAM84A Gene

GeneCards Summary for FAM84A Gene

FAM84A (Family With Sequence Similarity 84 Member A) is a Protein Coding gene. An important paralog of this gene is FAM84B.

Additional gene information for FAM84A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM84A Gene

Genomics for FAM84A Gene

GeneHancer (GH) Regulatory Elements for FAM84A Gene

Promoters and enhancers for FAM84A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I014631 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.4 1435 5.3 PKNOX1 FOXA2 NFIB SIN3A RAD21 RFX5 YY1 ZNF335 TCF12 EGR1 GC02M014635 FAM84A GC02M014636
GH02I014296 Enhancer 0.5 ENCODE 14.2 -335.1 -335148 1.1 SMARCE1 CTBP1 GATA3 DPF2 FAM84A RNU6-1288P GC02P014286 GC02P014362 LINC00276
GH02I014423 Enhancer 0.7 ENCODE 7.6 -208.0 -208046 3.2 SMAD1 BACH1 BMI1 BATF IRF4 ATF7 IKZF2 MAFK SMARCA5 ZNF687 FAM84A LINC00276 ENSG00000237261
GH02I014287 Enhancer 0.5 ENCODE 10.1 -344.5 -344513 0.8 CTCF CTBP1 GATA3 RFX1 DPF2 RFX5 GC02P014286 FAM84A GC02P014362 LINC00276
GH02I014134 Enhancer 0.4 ENCODE 10.5 -497.9 -497893 0.7 MAFK PRDM1 FAM84A GC02P014156 GC02P013975 LINC00276
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM84A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM84A gene promoter:

Genomic Locations for FAM84A Gene

Genomic Locations for FAM84A Gene
chr2:14,632,686-14,650,814
(GRCh38/hg38)
Size:
18,129 bases
Orientation:
Plus strand
chr2:14,772,810-14,790,933
(GRCh37/hg19)

Genomic View for FAM84A Gene

Genes around FAM84A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM84A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM84A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM84A Gene

Proteins for FAM84A Gene

  • Protein details for FAM84A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KN4-FA84A_HUMAN
    Recommended name:
    Protein FAM84A
    Protein Accession:
    Q96KN4
    Secondary Accessions:
    • A6NP76
    • Q86UZ2
    • Q8NAH7
    • Q8TAM5

    Protein attributes for FAM84A Gene

    Size:
    292 amino acids
    Molecular mass:
    32491 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM84A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM84A Gene

Post-translational modifications for FAM84A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM84A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM84A Gene

Domains & Families for FAM84A Gene

Gene Families for FAM84A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM84A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM84A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KN4

UniProtKB/Swiss-Prot:

FA84A_HUMAN :
  • Belongs to the FAM84 family.
Family:
  • Belongs to the FAM84 family.
genes like me logo Genes that share domains with FAM84A: view

Function for FAM84A Gene

Phenotypes From GWAS Catalog for FAM84A Gene

Phenotypes for FAM84A Gene

GenomeRNAi human phenotypes for FAM84A:
genes like me logo Genes that share phenotypes with FAM84A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM84A Gene

Localization for FAM84A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM84A gene
Compartment Confidence
peroxisome 2
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM84A Gene

Pathways & Interactions for FAM84A Gene

SuperPathways for FAM84A Gene

No Data Available

Interacting Proteins for FAM84A Gene

Gene Ontology (GO) - Biological Process for FAM84A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM84A Gene

Drugs & Compounds for FAM84A Gene

No Compound Related Data Available

Transcripts for FAM84A Gene

Unigene Clusters for FAM84A Gene

Family with sequence similarity 84, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM84A Gene

No ASD Table

Relevant External Links for FAM84A Gene

GeneLoc Exon Structure for
FAM84A
ECgene alternative splicing isoforms for
FAM84A

Expression for FAM84A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM84A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM84A Gene

This gene is overexpressed in Esophagus - Mucosa (x5.7) and Colon - Transverse (x5.3).

Protein differential expression in normal tissues from HIPED for FAM84A Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM84A Gene



Protein tissue co-expression partners for FAM84A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM84A Gene:

FAM84A

SOURCE GeneReport for Unigene cluster for FAM84A Gene:

Hs.260855

Evidence on tissue expression from TISSUES for FAM84A Gene

  • Nervous system(4.4)
  • Intestine(2.6)
genes like me logo Genes that share expression patterns with FAM84A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM84A Gene

Orthologs for FAM84A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM84A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM84A 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia FAM84A 33 34
  • 95.09 (n)
cow
(Bos Taurus)
Mammalia FAM84A 33 34
  • 93.61 (n)
mouse
(Mus musculus)
Mammalia Fam84a 33 16 34
  • 91.67 (n)
rat
(Rattus norvegicus)
Mammalia Fam84a 33
  • 90.53 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM84A 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM84A 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM84A 33 34
  • 80.26 (n)
lizard
(Anolis carolinensis)
Reptilia FAM84A 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam84a 33
  • 68.38 (n)
zebrafish
(Danio rerio)
Actinopterygii fam84a 33 34
  • 69.1 (n)
zgc63724 33
Species where no ortholog for FAM84A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM84A Gene

ENSEMBL:
Gene Tree for FAM84A (if available)
TreeFam:
Gene Tree for FAM84A (if available)

Paralogs for FAM84A Gene

Paralogs for FAM84A Gene

(1) SIMAP similar genes for FAM84A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM84A: view

Variants for FAM84A Gene

Sequence variations from dbSNP and Humsavar for FAM84A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000215319 -- 14,639,235(+) C/T 3_prime_UTR_variant
rs1000307819 -- 14,632,573(+) G/A upstream_transcript_variant
rs1000383205 -- 14,632,771(+) G/T 5_prime_UTR_variant
rs1000641760 -- 14,633,725(+) G/A intron_variant
rs1000641804 -- 14,631,184(+) T/C upstream_transcript_variant

Variation tolerance for FAM84A Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM84A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM84A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM84A Gene

Disorders for FAM84A Gene

Additional Disease Information for FAM84A

No disorders were found for FAM84A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM84A Gene

Publications for FAM84A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58

Products for FAM84A Gene

Sources for FAM84A Gene

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