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Aliases for FAM83F Gene

Aliases for FAM83F Gene

  • Family With Sequence Similarity 83 Member F 2 3 5
  • Family With Sequence Similarity 83, Member F 2

External Ids for FAM83F Gene

Previous GeneCards Identifiers for FAM83F Gene

  • GC22P038716
  • GC22P040390
  • GC22P023353

Summaries for FAM83F Gene

GeneCards Summary for FAM83F Gene

FAM83F (Family With Sequence Similarity 83 Member F) is a Protein Coding gene. An important paralog of this gene is FAM83G.

Additional gene information for FAM83F Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM83F Gene

Genomics for FAM83F Gene

GeneHancer (GH) Regulatory Elements for FAM83F Gene

Promoters and enhancers for FAM83F Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I039994 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 564.3 +3.7 3665 8.4 FOXA2 ATF1 ARNT SIN3A BRCA1 NCOA2 TCF12 ZNF766 GATA2 FOS FAM83F CACNA1I GC22M042048
GH22I039995 Enhancer 0.9 ENCODE dbSUPER 550.8 -0.7 -727 0.2 TEAD4 TAL1 TCF12 POLR2A NCOR1 EGR1 VEZF1 CBFA2T2 CREM EZH2 FAM83F GC22M042664
GH22I039958 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.2 -34.3 -34303 4.5 HDGF ATF1 ARNT IRF4 NCOA2 TCF12 ZNF766 ATF7 FOS RUNX3 ENSG00000225528 FAM83F GRAP2 ENTHD1 CACNA1I MIEF1 TNRC6B GC22P039976
GH22I039946 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 -45.0 -45020 7.7 HDGF ATF1 PKNOX1 SMAD1 ARNT NCOA2 TCF12 ZNF121 POLR2B ZNF766 GRAP2 ENTHD1 FAM83F TNRC6B ENSG00000225528
GH22I039965 Enhancer 1.1 ENCODE dbSUPER 15.7 -27.5 -27500 3.3 PKNOX1 ATF1 TCF12 ZNF766 GATA2 FOS ATF7 REST ZNF592 MBD2 FAM83F ENSG00000225528 MIEF1 GC22P039976 GRAP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM83F on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM83F gene promoter:

Genomic Locations for FAM83F Gene

Genomic Locations for FAM83F Gene
chr22:39,994,949-40,043,529
(GRCh38/hg38)
Size:
48,581 bases
Orientation:
Plus strand
chr22:40,390,953-40,439,533
(GRCh37/hg19)

Genomic View for FAM83F Gene

Genes around FAM83F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM83F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM83F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83F Gene

Proteins for FAM83F Gene

  • Protein details for FAM83F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEG4-FA83F_HUMAN
    Recommended name:
    Protein FAM83F
    Protein Accession:
    Q8NEG4
    Secondary Accessions:
    • Q96FD6

    Protein attributes for FAM83F Gene

    Size:
    500 amino acids
    Molecular mass:
    55486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM83F Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM83F Gene

Post-translational modifications for FAM83F Gene

No Post-translational modifications

Other Protein References for FAM83F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM83F Gene

Domains & Families for FAM83F Gene

Gene Families for FAM83F Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM83F Gene

Suggested Antigen Peptide Sequences for FAM83F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEG4

UniProtKB/Swiss-Prot:

FA83F_HUMAN :
  • Belongs to the FAM83 family.
Family:
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83F: view

Function for FAM83F Gene

Phenotypes From GWAS Catalog for FAM83F Gene

genes like me logo Genes that share phenotypes with FAM83F: view

Animal Model Products

miRNA for FAM83F Gene

miRTarBase miRNAs that target FAM83F

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM83F Gene

Localization for FAM83F Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM83F gene
Compartment Confidence
nucleus 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM83F Gene

Pathways & Interactions for FAM83F Gene

SuperPathways for FAM83F Gene

No Data Available

Interacting Proteins for FAM83F Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330432%0d%0a9606.ENSP00000255304%0d%0a9606.ENSP00000421380%0d%0a9606.ENSP00000265056%0d%0a9606.ENSP00000375639%0d%0a9606.ENSP00000358541%0d%0a
Selected Interacting proteins: Q8NEG4-FA83F_HUMAN ENSP00000330432 for FAM83F Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM83F Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM83F Gene

Drugs & Compounds for FAM83F Gene

No Compound Related Data Available

Transcripts for FAM83F Gene

mRNA/cDNA for FAM83F Gene

Unigene Clusters for FAM83F Gene

Family with sequence similarity 83, member F:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83F Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - - -
SP3:

Relevant External Links for FAM83F Gene

GeneLoc Exon Structure for
FAM83F
ECgene alternative splicing isoforms for
FAM83F

Expression for FAM83F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM83F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM83F Gene

This gene is overexpressed in Testis (x12.3), Esophagus - Mucosa (x5.6), Skin - Not Sun Exposed (Suprapubic) (x4.7), and Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for FAM83F Gene

This gene is overexpressed in Cerebrospinal fluid (27.6), Platelet (22.3), Pancreas (7.9), and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM83F Gene



Protein tissue co-expression partners for FAM83F Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM83F Gene:

FAM83F

SOURCE GeneReport for Unigene cluster for FAM83F Gene:

Hs.197680
genes like me logo Genes that share expression patterns with FAM83F: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM83F Gene

Orthologs for FAM83F Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM83F 33 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia FAM83F 33 34
  • 86.51 (n)
dog
(Canis familiaris)
Mammalia FAM83F 33 34
  • 85.33 (n)
mouse
(Mus musculus)
Mammalia Fam83f 33 16 34
  • 83.44 (n)
rat
(Rattus norvegicus)
Mammalia Fam83f 33
  • 83.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM83F 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM83F 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM83F 33 34
  • 64.79 (n)
lizard
(Anolis carolinensis)
Reptilia FAM83F 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam83f 33
  • 62.05 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-165i8.3 33
  • 58.5 (n)
fam83fb 34
  • 36 (a)
OneToMany
FAM83F (2 of 2) 34
  • 32 (a)
OneToMany
Species where no ortholog for FAM83F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM83F Gene

ENSEMBL:
Gene Tree for FAM83F (if available)
TreeFam:
Gene Tree for FAM83F (if available)

Paralogs for FAM83F Gene

Paralogs for FAM83F Gene

(2) SIMAP similar genes for FAM83F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM83F: view

Variants for FAM83F Gene

Sequence variations from dbSNP and Humsavar for FAM83F Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
VAR_038136 A breast cancer sample p.Ala418Val
rs1000084727 -- 40,028,595(+) G/A intron_variant
rs1000185687 -- 40,027,681(+) G/A intron_variant
rs1000261142 -- 40,025,398(+) G/A intron_variant
rs1000277988 -- 40,017,145(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM83F Gene

Variant ID Type Subtype PubMed ID
nsv955160 CNV deletion 24416366
nsv834201 CNV gain 17160897
nsv829229 CNV loss 20364138
nsv1109469 CNV deletion 24896259
esv3647771 CNV loss 21293372
esv3647769 CNV loss 21293372
esv3375117 CNV duplication 20981092
esv2676686 CNV deletion 23128226
esv2452848 CNV insertion 19546169

Variation tolerance for FAM83F Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.58; 88.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM83F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM83F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM83F Gene

Disorders for FAM83F Gene

Additional Disease Information for FAM83F

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM83F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM83F Gene

Publications for FAM83F Gene

  1. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt KT … Blagoev B (Science signaling 2011) 4 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PMID: 17342744) Dall'Era MA … Liu AY (The Prostate 2007) 3 58

Products for FAM83F Gene

Sources for FAM83F Gene

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