This gene encodes a member of the family with sequence similarity 83 protein family. The encoded protein may be involved in regulating MAPK signaling in cancer cells. [provided by RefSeq, Mar 2017] See more...

Aliases for FAM83C Gene

Aliases for FAM83C Gene

  • Family With Sequence Similarity 83 Member C 2 3 5
  • Protein FAM83C 3 4
  • C20orf128 3 4
  • DJ614O4.7 2 3
  • Family With Sequence Similarity 83, Member C 2
  • Chromosome 20 Open Reading Frame 128 2
  • EC 51
  • EC 1.6.5 51
  • FAM83C 5

External Ids for FAM83C Gene

Previous HGNC Symbols for FAM83C Gene

  • C20orf128

Previous GeneCards Identifiers for FAM83C Gene

  • GC20M033337
  • GC20M033874
  • GC20M030650
  • GC20M033875
  • GC20M033878
  • GC20M033882
  • GC20M033886

Summaries for FAM83C Gene

Entrez Gene Summary for FAM83C Gene

  • This gene encodes a member of the family with sequence similarity 83 protein family. The encoded protein may be involved in regulating MAPK signaling in cancer cells. [provided by RefSeq, Mar 2017]

GeneCards Summary for FAM83C Gene

FAM83C (Family With Sequence Similarity 83 Member C) is a Protein Coding gene. An important paralog of this gene is FAM83G.

UniProtKB/Swiss-Prot Summary for FAM83C Gene

Additional gene information for FAM83C Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM83C Gene

Genomics for FAM83C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM83C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J035292 Promoter/Enhancer 0.7 EPDnew dbSUPER 600.7 0.0 -13 0.1 HNRNPL ZNF48 FAM83C lnc-FAM83C-3 UQCC1
GH20J035290 Enhancer 0.5 dbSUPER 600.7 +1.5 1520 1 HNRNPL RCOR1 KDM1A ESRRA GATA2 FAM83C EIF6
GH20J035275 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17.6 +14.1 14115 5 HNRNPL ZNF629 CTCF POLR2A BACH1 ZNF143 ZIC2 RBFOX2 SMAD5 REST EIF6 MMP24OS ENSG00000261582 MMP24-AS1-EDEM2 EDEM2 FAM83C NCOA6 RBM12 CEP250 RBM39
GH20J035324 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 -35.5 -35459 5.8 GATAD2A CTCF ATF7 REST TFE3 SOX13 NFKBIZ NFRKB RCOR2 JUND UQCC1 CPNE1 RBM12 RBM39 RPL36P4 NCOA6 FAM83C FAM83C-AS1 EIF6 MMP24OS
GH20J035337 Enhancer 1 Ensembl ENCODE dbSUPER 11.4 -47.7 -47715 5.5 CTCF ZNF341 HMBOX1 JUND POLR2A RBM22 WT1 ZFHX2 RAD21 BHLHE40 UQCC1 MMP24OS FAM83C EIF6 FAM83C-AS1 GDF5-AS1 MIR499A MMP24 lnc-FAM83C-2 lnc-FAM83C-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM83C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM83C

Top Transcription factor binding sites by QIAGEN in the FAM83C gene promoter:
  • STAT3

Genomic Locations for FAM83C Gene

Genomic Locations for FAM83C Gene
6,695 bases
Minus strand
6,692 bases
Minus strand

Genomic View for FAM83C Gene

Genes around FAM83C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM83C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM83C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM83C Gene

Proteins for FAM83C Gene

  • Protein details for FAM83C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM83C
    Protein Accession:
    Secondary Accessions:
    • Q14D67
    • Q5JWN6
    • Q8N276

    Protein attributes for FAM83C Gene

    747 amino acids
    Molecular mass:
    81078 Da
    Quaternary structure:
    • May interact with RAF1.
    • Sequence=BAC03594.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for FAM83C Gene

Selected DME Specific Peptides for FAM83C Gene


Post-translational modifications for FAM83C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM83C Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FAM83C Gene

Gene Families for FAM83C Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FAM83C Gene

  • Protein of unknown function DUF1669

Suggested Antigen Peptide Sequences for FAM83C Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM83C (FA83C_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM83 family.
  • Belongs to the FAM83 family.
genes like me logo Genes that share domains with FAM83C: view

Function for FAM83C Gene

Molecular function for FAM83C Gene

UniProtKB/Swiss-Prot Function:
May play a role in MAPK signaling.

Enzyme Numbers (IUBMB) for FAM83C Gene

Phenotypes From GWAS Catalog for FAM83C Gene

Gene Ontology (GO) - Molecular Function for FAM83C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 24736947
genes like me logo Genes that share ontologies with FAM83C: view
genes like me logo Genes that share phenotypes with FAM83C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM83C

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM83C Gene

Localization for FAM83C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM83C gene
Compartment Confidence
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1
endoplasmic reticulum 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM83C Gene

Pathways & Interactions for FAM83C Gene

PathCards logo

SuperPathways for FAM83C Gene

No Data Available

Interacting Proteins for FAM83C Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000363529 Q9BQN1-FA83C_HUMAN for FAM83C Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM83C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA 21873635
genes like me logo Genes that share ontologies with FAM83C: view

No data available for Pathways by source and SIGNOR curated interactions for FAM83C Gene

Drugs & Compounds for FAM83C Gene

No Compound Related Data Available

Transcripts for FAM83C Gene

mRNA/cDNA for FAM83C Gene

4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM83C

Alternative Splicing Database (ASD) splice patterns (SP) for FAM83C Gene

No ASD Table

Relevant External Links for FAM83C Gene

GeneLoc Exon Structure for

Expression for FAM83C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM83C Gene

mRNA differential expression in normal tissues according to GTEx for FAM83C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.4), Skin - Not Sun Exposed (Suprapubic) (x14.7), Esophagus - Mucosa (x12.5), and Vagina (x4.9).

Protein differential expression in normal tissues from HIPED for FAM83C Gene

This gene is overexpressed in Heart (50.7) and Adipocyte (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM83C Gene

Protein tissue co-expression partners for FAM83C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM83C

SOURCE GeneReport for Unigene cluster for FAM83C Gene:

genes like me logo Genes that share expression patterns with FAM83C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM83C Gene

Orthologs for FAM83C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM83C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM83C 30 31
  • 99.2 (n)
(Canis familiaris)
Mammalia FAM83C 30 31
  • 84.97 (n)
(Bos Taurus)
Mammalia FAM83C 30 31
  • 84.34 (n)
(Mus musculus)
Mammalia Fam83c 30 17 31
  • 81.76 (n)
(Rattus norvegicus)
Mammalia Fam83c 30
  • 81.65 (n)
(Monodelphis domestica)
Mammalia FAM83C 31
  • 65 (a)
(Gallus gallus)
Aves FAM83C 31
  • 42 (a)
(Anolis carolinensis)
Reptilia FAM83C 31
  • 52 (a)
(Danio rerio)
Actinopterygii CR388068.1 31
  • 39 (a)
Species where no ortholog for FAM83C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM83C Gene

Gene Tree for FAM83C (if available)
Gene Tree for FAM83C (if available)
Evolutionary constrained regions (ECRs) for FAM83C: view image

Paralogs for FAM83C Gene

Paralogs for FAM83C Gene

genes like me logo Genes that share paralogs with FAM83C: view

Variants for FAM83C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM83C Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
718325 Benign: not provided 35,288,523(-) C/T SYNONYMOUS_VARIANT
781561 Benign: not provided 35,287,759(-) C/T SYNONYMOUS_VARIANT
rs193920940 Uncertain Significance: Malignant tumor of prostate 35,287,916(-) C/T MISSENSE_VARIANT
rs2425049 - p.Arg621Gln
rs35162625 - p.Glu134Lys

Additional dbSNP identifiers (rs#s) for FAM83C Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM83C Gene

Variant ID Type Subtype PubMed ID
nsv1059168 CNV loss 25217958
nsv585943 CNV loss 21841781
nsv954029 CNV deletion 24416366

Variation tolerance for FAM83C Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.59; 86.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM83C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM83C Gene

Disorders for FAM83C Gene

No disorders were found for FAM83C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM83C Gene

Publications for FAM83C Gene

  1. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. (PMID: 24736947) Cipriano R … Jackson MW (Molecular cancer research : MCR 2014) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for FAM83C Gene

Sources for FAM83C Gene