Aliases for FAM81A Gene

Aliases for FAM81A Gene

  • Family With Sequence Similarity 81 Member A 2 3 5
  • Protein FAM81A 3 4
  • Family With Sequence Similarity 81, Member A 2
  • MGC26690 2
  • FAM81A 5

External Ids for FAM81A Gene

Previous GeneCards Identifiers for FAM81A Gene

  • GC15P057518
  • GC15P059730
  • GC15P036552
  • GC15P059664

Summaries for FAM81A Gene

GeneCards Summary for FAM81A Gene

FAM81A (Family With Sequence Similarity 81 Member A) is a Protein Coding gene. An important paralog of this gene is FAM81B.

Additional gene information for FAM81A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM81A Gene

Genomics for FAM81A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM81A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J059368 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 605.2 -1.1 -1101 5.6 HNRNPL CREB1 GATAD2A PRDM10 REST POLR2A RCOR2 FOXA1 LARP7 STAT3 MYO1E FAM81A lnc-GTF2A2-6 RNF111 BNIP2 ENSG00000259735 LDHAL6B
GH15J059437 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 618.7 +65.4 65408 2.2 PRDM10 RFX1 ZSCAN4 POLR2A EZH2 ZNF600 ZNF341 ZBTB44 RFX3 ZBTB20 FAM81A lnc-GCNT3-3 MYO1E ENSG00000200252 GCNT3
GH15J059492 Enhancer 0.9 Ensembl ENCODE 26.2 +120.1 120108 1.2 CTCF ZNF143 REST RAD21 TRIM22 CEBPA RELA CEBPB RUNX3 BCLAF1 FAM81A MIR2116 MYO1E piR-35674-168 piR-43106-078 GCNT3
GH15J059409 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 14.8 +39.1 39104 3.7 SP1 GATAD2A CTCF BACH1 LARP7 STAT3 ZNF143 RELA RXRB RAD21 FAM81A MYO1E ENSG00000259674 ENSG00000200252 lnc-GCNT3-3 GCNT3
GH15J059455 Enhancer 0.7 Ensembl ENCODE 26.8 +83.6 83620 1.8 CTBP1 POLR2A ZNF217 JUND CTCF RAD21 DPF2 ELF1 ZNF687 SMARCE1 FAM81A lnc-GCNT3-3 piR-43106-078 MYO1E GCNT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM81A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM81A

Top Transcription factor binding sites by QIAGEN in the FAM81A gene promoter:
  • FOXO4
  • MyoD
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Olf-1
  • RSRFC4
  • Sox5

Genomic Locations for FAM81A Gene

Genomic Locations for FAM81A Gene
chr15:59,372,693-59,523,555
(GRCh38/hg38)
Size:
150,863 bases
Orientation:
Plus strand
chr15:59,664,892-59,815,751
(GRCh37/hg19)
Size:
150,860 bases
Orientation:
Plus strand

Genomic View for FAM81A Gene

Genes around FAM81A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM81A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM81A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM81A Gene

Proteins for FAM81A Gene

  • Protein details for FAM81A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBF8-FA81A_HUMAN
    Recommended name:
    Protein FAM81A
    Protein Accession:
    Q8TBF8

    Protein attributes for FAM81A Gene

    Size:
    368 amino acids
    Molecular mass:
    42392 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22537.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for FAM81A Gene

Post-translational modifications for FAM81A Gene

  • Ubiquitination at Lys119
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM81A Gene

Domains & Families for FAM81A Gene

Gene Families for FAM81A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM81A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM81A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM81A (FA81A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TBF8

UniProtKB/Swiss-Prot:

FA81A_HUMAN :
  • Belongs to the FAM81 family.
Family:
  • Belongs to the FAM81 family.
genes like me logo Genes that share domains with FAM81A: view

Function for FAM81A Gene

Phenotypes From GWAS Catalog for FAM81A Gene

Phenotypes for FAM81A Gene

genes like me logo Genes that share phenotypes with FAM81A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM81A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM81A Gene

Localization for FAM81A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM81A gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM81A Gene

Pathways & Interactions for FAM81A Gene

PathCards logo

SuperPathways for FAM81A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM81A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM81A Gene

Drugs & Compounds for FAM81A Gene

No Compound Related Data Available

Transcripts for FAM81A Gene

mRNA/cDNA for FAM81A Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM81A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM81A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: -
SP9: - - - - - -
SP10: -

Relevant External Links for FAM81A Gene

GeneLoc Exon Structure for
FAM81A

Expression for FAM81A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM81A Gene

mRNA differential expression in normal tissues according to GTEx for FAM81A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.8), Brain - Anterior cingulate cortex (BA24) (x8.0), Brain - Cortex (x7.9), Brain - Hippocampus (x4.7), and Brain - Amygdala (x4.0).

Protein differential expression in normal tissues from HIPED for FAM81A Gene

This gene is overexpressed in Bone (20.3), Uterus (16.9), Colon (7.3), and Ovary (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM81A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM81A

SOURCE GeneReport for Unigene cluster for FAM81A Gene:

Hs.531168

Evidence on tissue expression from TISSUES for FAM81A Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with FAM81A: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM81A Gene

Orthologs for FAM81A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM81A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM81A 30 31
  • 99.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM81A 30 31
  • 91.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM81A 30 31
  • 90.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam81a 30
  • 87.91 (n)
Mouse
(Mus musculus)
Mammalia Fam81a 30 17 31
  • 87.82 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM81A 31
  • 84 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM81A 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM81A 30 31
  • 72.21 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM81A 31
  • 60 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToMany
Species where no ortholog for FAM81A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FAM81A Gene

ENSEMBL:
Gene Tree for FAM81A (if available)
TreeFam:
Gene Tree for FAM81A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM81A: view image

Paralogs for FAM81A Gene

Paralogs for FAM81A Gene

(1) SIMAP similar genes for FAM81A Gene using alignment to 10 proteins:

  • FA81A_HUMAN
  • H0YKL6_HUMAN
  • H0YKQ6_HUMAN
  • H0YKW2_HUMAN
  • H0YLQ5_HUMAN
  • H0YMF2_HUMAN
  • H0YMW3_HUMAN
  • H0YMX7_HUMAN
  • H0YN47_HUMAN
  • H0YN94_HUMAN
genes like me logo Genes that share paralogs with FAM81A: view

Variants for FAM81A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM81A Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs769200365 Not Provided: CIC-DUX Sarcoma 59,514,274(+) A/AT INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for FAM81A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM81A Gene

Variant ID Type Subtype PubMed ID
esv27356 CNV gain 19812545
esv3636642 CNV loss 21293372
nsv1134454 CNV deletion 24896259
nsv1552 CNV insertion 18451855
nsv527307 CNV gain 19592680
nsv569604 CNV loss 21841781
nsv7266 OTHER inversion 18451855

Variation tolerance for FAM81A Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM81A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM81A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM81A Gene

Disorders for FAM81A Gene

No disorders were found for FAM81A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM81A Gene

Publications for FAM81A Gene

  1. FAM81A protein, a novel component of the postsynaptic density in adult brain. (PMID: 30735723) Dosemeci A … Tao-Cheng JH (Neuroscience letters 2019) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. (PMID: 27634302) Oliviero G … Cagney G (Molecular & cellular proteomics : MCP 2016) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3

Products for FAM81A Gene

Sources for FAM81A Gene