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Aliases for FAM78B Gene

Aliases for FAM78B Gene

  • Family With Sequence Similarity 78 Member B 2 3 5
  • Family With Sequence Similarity 78, Member B 2
  • Protein FAM78B 3

External Ids for FAM78B Gene

Previous GeneCards Identifiers for FAM78B Gene

  • GC01M162772
  • GC01M164293
  • GC01M164305
  • GC01M166027
  • GC01M137286

Summaries for FAM78B Gene

GeneCards Summary for FAM78B Gene

FAM78B (Family With Sequence Similarity 78 Member B) is a Protein Coding gene. An important paralog of this gene is FAM78A.

Additional gene information for FAM78B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM78B Gene

Genomics for FAM78B Gene

GeneHancer (GH) Regulatory Elements for FAM78B Gene

Promoters and enhancers for FAM78B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J166166 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.0 42 1.5 HDAC1 RB1 ARNT SIN3A DMAP1 ZBTB40 ZNF335 ZNF766 GLIS2 ZNF207 FAM78B ENSG00000230898
GH01J166133 Enhancer 0.5 FANTOM5 0.3 +33.3 33331 0.1 CTCF CEBPB CEBPG PIR48757 MIR921 FAM78B
GH01J166170 Enhancer 0.2 ENCODE 0.7 -4.0 -3970 0.2 FAM78B LOC284685
GH01J166185 Enhancer 0.2 ENCODE 0.4 -18.3 -18250 0.2 MIR921 FAM78B LOC284685
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM78B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM78B gene promoter:
  • STAT1alpha
  • STAT1
  • STAT1beta
  • Elk-1
  • Pax-4a
  • GATA-3
  • Pax-5
  • N-Myc
  • CUTL1
  • Pax-2

Genomic Locations for FAM78B Gene

Genomic Locations for FAM78B Gene
chr1:166,057,426-166,166,969
(GRCh38/hg38)
Size:
109,544 bases
Orientation:
Minus strand
chr1:166,026,674-166,136,206
(GRCh37/hg19)
Size:
109,533 bases
Orientation:
Minus strand

Genomic View for FAM78B Gene

Genes around FAM78B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM78B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM78B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM78B Gene

Proteins for FAM78B Gene

  • Protein details for FAM78B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VT40-FA78B_HUMAN
    Recommended name:
    Protein FAM78B
    Protein Accession:
    Q5VT40
    Secondary Accessions:
    • B7Z693

    Protein attributes for FAM78B Gene

    Size:
    261 amino acids
    Molecular mass:
    29835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM78B Gene

Post-translational modifications for FAM78B Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM78B Gene

Domains & Families for FAM78B Gene

Gene Families for FAM78B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM78B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM78B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VT40

UniProtKB/Swiss-Prot:

FA78B_HUMAN :
  • Belongs to the FAM78 family.
Family:
  • Belongs to the FAM78 family.
genes like me logo Genes that share domains with FAM78B: view

Function for FAM78B Gene

genes like me logo Genes that share phenotypes with FAM78B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM78B Gene

Localization for FAM78B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM78B gene
Compartment Confidence
mitochondrion 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM78B Gene

Pathways & Interactions for FAM78B Gene

SuperPathways for FAM78B Gene

No Data Available

Interacting Proteins for FAM78B Gene

Gene Ontology (GO) - Biological Process for FAM78B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM78B Gene

Drugs & Compounds for FAM78B Gene

No Compound Related Data Available

Transcripts for FAM78B Gene

mRNA/cDNA for FAM78B Gene

Unigene Clusters for FAM78B Gene

Family with sequence similarity 78, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM78B Gene

No ASD Table

Relevant External Links for FAM78B Gene

GeneLoc Exon Structure for
FAM78B
ECgene alternative splicing isoforms for
FAM78B

Expression for FAM78B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM78B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FAM78B Gene:

FAM78B

SOURCE GeneReport for Unigene cluster for FAM78B Gene:

Hs.133029

Evidence on tissue expression from TISSUES for FAM78B Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FAM78B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM78B Gene

Orthologs for FAM78B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM78B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM78B 34 33
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM78B 34 33
  • 97.32 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM78B 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM78B 34 33
  • 96.68 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam78b 16 34 33
  • 96.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM78B 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM78B 34 33
  • 83.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM78B 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam78b 33
  • 82.38 (n)
zebrafish
(Danio rerio)
Actinopterygii FAM78B (1 of 2) 34
  • 82 (a)
OneToMany
fam78bb 33
  • 75.35 (n)
FP102157.1 34
  • 74 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for FAM78B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM78B Gene

ENSEMBL:
Gene Tree for FAM78B (if available)
TreeFam:
Gene Tree for FAM78B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM78B: view image

Paralogs for FAM78B Gene

Paralogs for FAM78B Gene

(1) SIMAP similar genes for FAM78B Gene using alignment to 4 proteins:

  • FA78B_HUMAN
  • F1T0K0_HUMAN
  • H7C075_HUMAN
  • H7C3M6_HUMAN
genes like me logo Genes that share paralogs with FAM78B: view

Variants for FAM78B Gene

Sequence variations from dbSNP and Humsavar for FAM78B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000006492 -- 166,162,344(-) T/C intron_variant
rs1000015354 -- 166,107,824(-) C/G intron_variant
rs1000106707 -- 166,167,569(-) A/C/G upstream_transcript_variant
rs1000111359 -- 166,130,272(-) G/A intron_variant
rs1000147020 -- 166,113,079(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM78B Gene

Variant ID Type Subtype PubMed ID
esv2719162 CNV deletion 23290073
nsv1112220 CNV deletion 24896259
nsv1127041 CNV deletion 24896259
nsv1136101 CNV deletion 24896259
nsv475739 CNV novel sequence insertion 20440878
nsv955475 CNV deletion 24416366

Variation tolerance for FAM78B Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM78B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM78B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM78B Gene

Disorders for FAM78B Gene

Additional Disease Information for FAM78B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM78B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM78B Gene

Publications for FAM78B Gene

  1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 44 58
  2. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FAM78B Gene

Sources for FAM78B Gene

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