Aliases for FAM72B Gene

Aliases for FAM72B Gene

  • Family With Sequence Similarity 72 Member B 2 3 5
  • Protein FAM72B 3 4
  • Family With Sequence Similarity 72, Member B 2
  • Amyloid-Beta Peptide-Induced Protein P17 3
  • RP11-439A17.6 3
  • P17 3

External Ids for FAM72B Gene

Previous GeneCards Identifiers for FAM72B Gene

  • GC01U901174
  • GC01P120641
  • GC01P120837

Summaries for FAM72B Gene

GeneCards Summary for FAM72B Gene

FAM72B (Family With Sequence Similarity 72 Member B) is a Protein Coding gene. An important paralog of this gene is FAM72A.

Additional gene information for FAM72B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM72B Gene

Genomics for FAM72B Gene

GeneHancer (GH) Regulatory Elements for FAM72B Gene

Promoters and enhancers for FAM72B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J121183 Promoter 0.3 Ensembl 500.7 -0.2 -205 9.8 FAM72B SRGAP2C piR-38352-032
GH01J121201 Enhancer 0.8 Ensembl 0.4 -17.1 -17105 15.6 ZNF639 ZNF10 ZBTB26 ZEB1 OSR2 KLF8 ZBTB1 ZNF610 IKZF3 EP300 FAM72B SRGAP2C piR-38352-032
GH01J121181 Promoter 0.3 Ensembl 0.7 +5.0 4995 0.2 FAM72B SRGAP2C RF00994-051
GH01J121220 Enhancer 0.3 Ensembl 0.3 -37.9 -37905 11.2 ZNF770 piR-38352-032 FAM72B SRGAP2C
GH01J121178 Enhancer 0.2 Ensembl 0.4 +8.2 8195 0.2 RF00994-051 FAM72B SRGAP2C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM72B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM72B

Top Transcription factor binding sites by QIAGEN in the FAM72B gene promoter:
  • AREB6
  • CBF(2)
  • CBF-A
  • FOXO4
  • GCNF
  • GCNF-1
  • GCNF-2
  • Nkx2-2
  • Sox5

Genomic Locations for FAM72B Gene

Genomic Locations for FAM72B Gene
chr1:121,167,646-121,186,896
(GRCh38/hg38)
Size:
19,251 bases
Orientation:
Minus strand
chr1:120,837,756-120,855,681
(GRCh37/hg19)
Size:
17,926 bases
Orientation:
Plus strand

Genomic View for FAM72B Gene

Genes around FAM72B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM72B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM72B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM72B Gene

Proteins for FAM72B Gene

  • Protein details for FAM72B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X60-FA72B_HUMAN
    Recommended name:
    Protein FAM72B
    Protein Accession:
    Q86X60
    Secondary Accessions:
    • B2RPQ5
    • Q5QP15

    Protein attributes for FAM72B Gene

    Size:
    149 amino acids
    Molecular mass:
    16617 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Highly homologous to GCUD2 but localized to a distinct locus.

    Alternative splice isoforms for FAM72B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM72B Gene

Post-translational modifications for FAM72B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM72B Gene

No data available for DME Specific Peptides for FAM72B Gene

Domains & Families for FAM72B Gene

Gene Families for FAM72B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM72B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM72B Gene

GenScript: Design optimal peptide antigens:
  • Family with sequence similarity 72, member B (B2RPQ4_HUMAN)
  • Protein FAM72B (FA72B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86X60

UniProtKB/Swiss-Prot:

FA72B_HUMAN :
  • Belongs to the FAM72 family.
Family:
  • Belongs to the FAM72 family.
genes like me logo Genes that share domains with FAM72B: view

Function for FAM72B Gene

Phenotypes for FAM72B Gene

genes like me logo Genes that share phenotypes with FAM72B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM72B Gene

Localization for FAM72B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM72B gene
Compartment Confidence
cytosol 4
extracellular 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM72B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0016020 membrane IBA 21873635
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FAM72B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM72B Gene

Pathways & Interactions for FAM72B Gene

PathCards logo

SuperPathways for FAM72B Gene

No Data Available

Interacting Proteins for FAM72B Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000358397 for FAM72B Gene via STRING

Symbol External ID(s) Details
OTX1
;

Gene Ontology (GO) - Biological Process for FAM72B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM72B Gene

Drugs & Compounds for FAM72B Gene

No Compound Related Data Available

Transcripts for FAM72B Gene

mRNA/cDNA for FAM72B Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM72B Gene

No ASD Table

Relevant External Links for FAM72B Gene

GeneLoc Exon Structure for
FAM72B

Expression for FAM72B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM72B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM72B

SOURCE GeneReport for Unigene cluster for FAM72B Gene:

Hs.339665

Evidence on tissue expression from TISSUES for FAM72B Gene

  • Skin(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with FAM72B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM72B Gene

Orthologs for FAM72B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM72B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam72a 31
  • 89 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM72A 31
  • 88 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 72 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FAM72B 31
  • 63 (a)
OneToMany
Species where no ortholog for FAM72B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM72B Gene

ENSEMBL:
Gene Tree for FAM72B (if available)
TreeFam:
Gene Tree for FAM72B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM72B: view image

Paralogs for FAM72B Gene

Paralogs for FAM72B Gene

(3) SIMAP similar genes for FAM72B Gene using alignment to 3 proteins:

  • FA72B_HUMAN
  • B2RPQ4_HUMAN
  • Q5QP12_HUMAN
genes like me logo Genes that share paralogs with FAM72B: view

Variants for FAM72B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM72B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1572701 - p.Pro94Leu
rs17838150 - p.Gly82Val

Additional dbSNP identifiers (rs#s) for FAM72B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM72B Gene

Variant ID Type Subtype PubMed ID
nsv524681 CNV gain 19592680

Variation tolerance for FAM72B Gene

Gene Damage Index Score: 4.43; 63.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM72B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM72B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM72B Gene

Disorders for FAM72B Gene

Additional Disease Information for FAM72B

No disorders were found for FAM72B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM72B Gene

Publications for FAM72B Gene

  1. All-or-(N)One - an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci. (PMID: 26206078) Kutzner A … Heese K (Genomics 2015) 2 3 54
  2. Identification and characterisation of the novel amyloid-beta peptide-induced protein p17. (PMID: 19755123) Nehar S … Heese K (FEBS letters 2009) 2 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for FAM72B Gene

Sources for FAM72B Gene