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Aliases for FAM71C Gene
Aliases for FAM71C Gene
External Ids for FAM71C Gene
- HGNC: 28594
- Entrez Gene: 196472
- Ensembl: ENSG00000180219
- UniProtKB: Q8NEG0
Previous GeneCards Identifiers for FAM71C Gene
- GC12P098544
- GC12P100041
- GC12P097103
Summaries for FAM71C Gene
GeneCards Summary for FAM71C Gene
FAM71C (Family With Sequence Similarity 71 Member C) is a Protein Coding gene. An important paralog of this gene is FAM71A.
Additional gene information for FAM71C Gene
- HGNC(28594)
- Entrez Gene(196472)
- Ensembl(ENSG00000180219)
- UniProtKB(Q8NEG0)
- Open Targets Platform(ENSG00000180219)
- Search for FAM71C at DataMed
- Search for FAM71C at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM71C Gene
Genomics for FAM71C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FAM71C Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J099647 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -19 | 0.1 | FAM71C piR-31292-035 lnc-UHRF1BP1L-4 ANKS1B | ||
| GH12J099619 | Enhancer | 0.5 | Ensembl | 11.4 | -27.9 | -27852 | 0.2 | CTCF FOXA1 RAD21 TRIM22 SMC3 ZNF654 ZNF2 ZNF143 | FAM71C piR-31292-035 lnc-UHRF1BP1L-4 piR-57461-051 ANKS1B APAF1 | |
| GH12J099609 | Enhancer | 0.4 | Ensembl ENCODE | 11.2 | -37.9 | -37852 | 1 | POU5F1 | FAM71C piR-31292-035 piR-57461-051 lnc-UHRF1BP1L-4 ANKS1B APAF1 | |
| GH12J099611 | Enhancer | 0.3 | Ensembl | 12 | -36.1 | -36052 | 0.6 | JUND FOS | FAM71C piR-31292-035 piR-57461-051 lnc-UHRF1BP1L-4 ANKS1B APAF1 | |
| GH12J099680 | Promoter | 0.3 | EPDnew | 11.5 | +33.0 | 33044 | 0.1 | ANKS1B FAM71C piR-36588-106 lnc-UHRF1BP1L-4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FAM71C on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM71C
- Top Transcription factor binding sites by QIAGEN in the FAM71C gene promoter:
-
- FOXD3
- FOXJ2
- FOXJ2 (long isoform)
- ISGF-3
- LyF-1
- Meis-1b
- SREBP-1a
- SREBP-1b
- SREBP-1c
- TBP
Genomic Locations for FAM71C Gene
Genomic Locations for FAM71C Gene
- chr12:99,647,753-99,650,114
- (GRCh38/hg38)
- Size:
- 2,362 bases
- Orientation:
- Plus strand
- chr12:100,041,531-100,043,827
- (GRCh37/hg19)
- Size:
- 2,297 bases
- Orientation:
- Plus strand
Genomic View for FAM71C Gene
Genes around FAM71C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q23.1 by HGNC
- 12q23.1 by Entrez Gene
- 12q23.1 by Ensembl
FAM71C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM71C Gene
Proteins for FAM71C Gene
-
Protein details for FAM71C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEG0-FA71C_HUMAN
- Recommended name:
- Protein FAM71C
- Protein Accession:
- Q8NEG0
- B2R6Y6
Protein attributes for FAM71C Gene
- Size:
- 241 amino acids
- Molecular mass:
- 27472 Da
- Quaternary structure:
- No Data Available
Protein Expression for FAM71C Gene
Post-translational modifications for FAM71C Gene
No Post-translational modifications
Other Protein References for FAM71C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-FAM71C polyclonal antibody
- Invitrogen Antibodies for FAM71C (AFLGC-FAM71C)
- antibodies-online: Show 6 available FAM71C Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for FAM71C
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM71C
- Origene Custom Protein Services for FAM71C
- Novus Biologicals lysates for FAM71C
No data available for DME Specific Peptides for FAM71C Gene
Domains & Families for FAM71C Gene
Gene Families for FAM71C Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for FAM71C Gene
- GenScript: Design optimal peptide antigens:
-
- Protein FAM71C (FA71C_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8NEG0- Family:
-
- Belongs to the FAM71 family.
Function for FAM71C Gene
Phenotypes From GWAS Catalog for FAM71C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for FAM71C Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FAM71C - Select products 50% OFF >
- * FAM71C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FAM71C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FAM71C
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM71C
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FAM71C
- Browse OriGene Inhibitory RNA Products For FAM71C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM71C
Clone Products
- Applied Biological Materials (abm): Clones for FAM71C - Select products 50% OFF >
- * FAM71C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FAM71C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FAM71C
Cell Line Products
-
Horizon Cell Lines for FAM71C
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM71C Gene
Localization for FAM71C Gene
| Compartment | Confidence |
|---|---|
| extracellular | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM71C Gene
Pathways & Interactions for FAM71C Gene
Interacting Proteins for FAM71C Gene
Selected Interacting proteins:
Q8NEG0-FA71C_HUMAN
ENSP00000315247
for FAM71C Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FAM71C
No data available for Pathways by source and SIGNOR curated interactions for FAM71C Gene
Transcripts for FAM71C Gene
mRNA/cDNA for FAM71C Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000324341 1864 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FAM71C - Select products 50% OFF >
- * FAM71C CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FAM71C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FAM71C
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM71C
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FAM71C
- Browse OriGene Inhibitory RNA Products For FAM71C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM71C
Clone Products
- Applied Biological Materials (abm): Clones for FAM71C - Select products 50% OFF >
- * FAM71C as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FAM71C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FAM71C
Relevant External Links for FAM71C Gene
- GeneLoc Exon Structure for
- FAM71C
Expression for FAM71C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for FAM71C Gene
This gene is overexpressed in Testis (x51.6).
This gene is overexpressed in Monocytes (60.1) and Brain (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM71C Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM71C
SOURCE GeneReport for Unigene cluster for FAM71C Gene:
Hs.591011Primer Products
-
OriGene qPCR primer pairs for FAM71C
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM71C Gene
Orthologs for FAM71C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FAM71C 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | FAM71C 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for FAM71C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for FAM71C Gene
- ENSEMBL:
- Gene Tree for FAM71C (if available)
- TreeFam:
- Gene Tree for FAM71C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FAM71C: view image
Paralogs for FAM71C Gene
Paralogs for FAM71C Gene
(5) SIMAP similar genes for FAM71C Gene using alignment to 1 proteins:
- FA71C_HUMAN
Pseudogenes.org Pseudogenes for FAM71C Gene
Variants for FAM71C Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM71C Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11109968 | - | p.Arg30Gly | |||
| rs11109969 | - | p.Met71Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1549n100 | CNV | loss | 25217958 |
| dgv2824n54 | CNV | loss | 21841781 |
| esv32717 | CNV | gain | 17666407 |
| nsv1045504 | CNV | loss | 25217958 |
| nsv559954 | CNV | loss | 21841781 |
| nsv559956 | CNV | loss | 21841781 |
| nsv559958 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.24;
81.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FAM71C Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM71C Gene
Disorders for FAM71C Gene
Additional Disease Information for FAM71C
No disorders were found for FAM71C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM71C Gene
Publications for FAM71C Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
- Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3
ExternalLinks
Products for FAM71C Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FAM71C
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM71C
- Origene Custom Protein Services for FAM71C
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FAM71C
- Browse OriGene Inhibitory RNA Products For FAM71C
- OriGene qPCR primer pairs for FAM71C
- OriGene CRISPR knockouts for FAM71C
- OriGene ORF clones in human for FAM71C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FAM71C
- Sino Biological Human cDNA Clone for FAM71C
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals lysates for FAM71C
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for FAM71C (AFLGC-FAM71C)
- VectorBuilder Custom and pre-made DNA vectors for FAM71C (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FAM71C (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FAM71C (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FAM71C CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FAM71C
- antibodies-online: Show 6 available FAM71C Antibodies ranked by validation data
- antibodies-online: Search results for available FAM71C related products ranked by validation data
- antibodies-online: Search results for available FAM71C related products ranked by validation data
- Horizon Cell Lines for FAM71C
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FAM71C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FAM71C
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FAM71C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM71C
Sources for FAM71C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB