Aliases for FAM71C Gene

Aliases for FAM71C Gene

  • Family With Sequence Similarity 71 Member C 2 3 5
  • Protein FAM71C 3 4
  • Family With Sequence Similarity 71, Member C 2
  • MGC39520 2
  • FAM71C 5

External Ids for FAM71C Gene

Previous GeneCards Identifiers for FAM71C Gene

  • GC12P098544
  • GC12P100041
  • GC12P097103

Summaries for FAM71C Gene

GeneCards Summary for FAM71C Gene

FAM71C (Family With Sequence Similarity 71 Member C) is a Protein Coding gene. An important paralog of this gene is FAM71A.

Additional gene information for FAM71C Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM71C Gene

Genomics for FAM71C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM71C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J099647 Promoter 0.3 EPDnew 600.7 0.0 -19 0.1 FAM71C piR-31292-035 lnc-UHRF1BP1L-4 ANKS1B
GH12J099619 Enhancer 0.5 Ensembl 11.4 -27.9 -27852 0.2 CTCF FOXA1 RAD21 TRIM22 SMC3 ZNF654 ZNF2 ZNF143 FAM71C piR-31292-035 lnc-UHRF1BP1L-4 piR-57461-051 ANKS1B APAF1
GH12J099609 Enhancer 0.4 Ensembl ENCODE 11.2 -37.9 -37852 1 POU5F1 FAM71C piR-31292-035 piR-57461-051 lnc-UHRF1BP1L-4 ANKS1B APAF1
GH12J099611 Enhancer 0.3 Ensembl 12 -36.1 -36052 0.6 JUND FOS FAM71C piR-31292-035 piR-57461-051 lnc-UHRF1BP1L-4 ANKS1B APAF1
GH12J099680 Promoter 0.3 EPDnew 11.5 +33.0 33044 0.1 ANKS1B FAM71C piR-36588-106 lnc-UHRF1BP1L-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM71C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM71C

Top Transcription factor binding sites by QIAGEN in the FAM71C gene promoter:
  • FOXD3
  • FOXJ2
  • FOXJ2 (long isoform)
  • ISGF-3
  • LyF-1
  • Meis-1b
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • TBP

Genomic Locations for FAM71C Gene

Genomic Locations for FAM71C Gene
chr12:99,647,753-99,650,114
(GRCh38/hg38)
Size:
2,362 bases
Orientation:
Plus strand
chr12:100,041,531-100,043,827
(GRCh37/hg19)
Size:
2,297 bases
Orientation:
Plus strand

Genomic View for FAM71C Gene

Genes around FAM71C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM71C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM71C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM71C Gene

Proteins for FAM71C Gene

  • Protein details for FAM71C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEG0-FA71C_HUMAN
    Recommended name:
    Protein FAM71C
    Protein Accession:
    Q8NEG0
    Secondary Accessions:
    • B2R6Y6

    Protein attributes for FAM71C Gene

    Size:
    241 amino acids
    Molecular mass:
    27472 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM71C Gene

Post-translational modifications for FAM71C Gene

No Post-translational modifications

Other Protein References for FAM71C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM71C Gene

Domains & Families for FAM71C Gene

Gene Families for FAM71C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM71C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM71C Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM71C (FA71C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEG0

UniProtKB/Swiss-Prot:

FA71C_HUMAN :
  • Belongs to the FAM71 family.
Family:
  • Belongs to the FAM71 family.
genes like me logo Genes that share domains with FAM71C: view

Function for FAM71C Gene

Phenotypes From GWAS Catalog for FAM71C Gene

Gene Ontology (GO) - Molecular Function for FAM71C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FAM71C: view
genes like me logo Genes that share phenotypes with FAM71C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM71C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM71C Gene

Localization for FAM71C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM71C gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM71C Gene

Pathways & Interactions for FAM71C Gene

PathCards logo

SuperPathways for FAM71C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM71C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM71C Gene

Drugs & Compounds for FAM71C Gene

No Compound Related Data Available

Transcripts for FAM71C Gene

mRNA/cDNA for FAM71C Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM71C

Alternative Splicing Database (ASD) splice patterns (SP) for FAM71C Gene

No ASD Table

Relevant External Links for FAM71C Gene

GeneLoc Exon Structure for
FAM71C

Expression for FAM71C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM71C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for FAM71C Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for FAM71C Gene

This gene is overexpressed in Monocytes (60.1) and Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM71C Gene



Protein tissue co-expression partners for FAM71C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM71C

SOURCE GeneReport for Unigene cluster for FAM71C Gene:

Hs.591011
genes like me logo Genes that share expression patterns with FAM71C: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM71C Gene

Orthologs for FAM71C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM71C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM71C 30 31
  • 98.76 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 67 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 57 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia FAM71C 31
  • 29 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 45 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
Species where no ortholog for FAM71C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FAM71C Gene

ENSEMBL:
Gene Tree for FAM71C (if available)
TreeFam:
Gene Tree for FAM71C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM71C: view image

Paralogs for FAM71C Gene

(5) SIMAP similar genes for FAM71C Gene using alignment to 1 proteins:

  • FA71C_HUMAN

Pseudogenes.org Pseudogenes for FAM71C Gene

genes like me logo Genes that share paralogs with FAM71C: view

Variants for FAM71C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM71C Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11109968 - p.Arg30Gly
rs11109969 - p.Met71Val

Additional dbSNP identifiers (rs#s) for FAM71C Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM71C Gene

Variant ID Type Subtype PubMed ID
dgv1549n100 CNV loss 25217958
dgv2824n54 CNV loss 21841781
esv32717 CNV gain 17666407
nsv1045504 CNV loss 25217958
nsv559954 CNV loss 21841781
nsv559956 CNV loss 21841781
nsv559958 CNV loss 21841781

Variation tolerance for FAM71C Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM71C Gene

Human Gene Mutation Database (HGMD)
FAM71C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM71C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM71C Gene

Disorders for FAM71C Gene

No disorders were found for FAM71C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM71C Gene

Publications for FAM71C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3

Products for FAM71C Gene

Sources for FAM71C Gene