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Aliases for FAM71A Gene

Aliases for FAM71A Gene

  • Family With Sequence Similarity 71 Member A 2 3 5
  • Testis Secretory Sperm-Binding Protein Li 209a 3
  • Family With Sequence Similarity 71, Member A 2
  • Golgi-Associated Rab2B Interactor-Like 4 3
  • Protein FAM71A 3
  • GARI-L4 3

External Ids for FAM71A Gene

Previous GeneCards Identifiers for FAM71A Gene

  • GC01P209187
  • GC01P210865
  • GC01P212798
  • GC01P183474

Summaries for FAM71A Gene

Entrez Gene Summary for FAM71A Gene

  • This gene encodes a protein that interacts with the Rab2B small GTPase and may be important for integrity of the Golgi body. A knockdown of this gene induces fragmentation of the Golgi, similar to the effect seen with a knockdown of the Rab2B small GTPase. The encoded protein has an N-terminal Rab-binding domain specific for Rab2B. [provided by RefSeq, Feb 2017]

GeneCards Summary for FAM71A Gene

FAM71A (Family With Sequence Similarity 71 Member A) is a Protein Coding gene. An important paralog of this gene is FAM71B.

Additional gene information for FAM71A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM71A Gene

Genomics for FAM71A Gene

GeneHancer (GH) Regulatory Elements for FAM71A Gene

Promoters and enhancers for FAM71A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I212624 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 +0.0 8 0.1 FAM71A GC01P212626 PIR57803 ENSG00000235862
GH01I212664 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE 11.1 +42.5 42497 4.2 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF213 E2F8 ZNF207 ZNF143 ENSG00000237980 LOC102723761 FAM71A DTL SPATA45 PPP2R5A ATF3 BATF3 ANGEL2 RPS6KC1
GH01I212594 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -28.0 -27991 3.3 PKNOX1 FOXA2 ARNT NEUROD1 FEZF1 ZNF2 YY1 ZNF213 ZNF143 ZNF207 ANGEL2 ATF3 FAM71A ENSG00000235862 BATF3 FLVCR1 TMEM206 PPP2R5A GC01M212615
GH01I212476 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -146.7 -146674 1.7 PKNOX1 SMAD1 ATF1 IRF4 BRCA1 ZNF766 ARID2 ZNF143 ATF7 RUNX3 LOC105372907 ATF3 NENF FAM71A ENSG00000235862 BATF3 TMEM206 RPL21P28 ENSG00000212187 VASH2
GH01I212469 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -154.2 -154167 1.3 ZNF687 L3MBTL2 NRF1 USF2 DPF2 FOSL1 JUND CREB1 FOS FOSL2 NENF FAM71A ENSG00000235862 ATF3 TMEM206 BATF3 LOC105372907 ENSG00000212187 VASH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM71A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM71A gene promoter:

Genomic Locations for FAM71A Gene

Genomic Locations for FAM71A Gene
2,332 bases
Plus strand

Genomic View for FAM71A Gene

Genes around FAM71A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM71A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM71A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM71A Gene

Proteins for FAM71A Gene

  • Protein details for FAM71A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM71A
    Protein Accession:
    Secondary Accessions:
    • Q5VTZ1

    Protein attributes for FAM71A Gene

    594 amino acids
    Molecular mass:
    63177 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM71A Gene

Post-translational modifications for FAM71A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM71A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM71A Gene

Domains & Families for FAM71A Gene

Gene Families for FAM71A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM71A Gene


Suggested Antigen Peptide Sequences for FAM71A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM71 family.
  • Belongs to the FAM71 family.
genes like me logo Genes that share domains with FAM71A: view

Function for FAM71A Gene

genes like me logo Genes that share phenotypes with FAM71A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM71A Gene

Localization for FAM71A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM71A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM71A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with FAM71A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FAM71A Gene

Pathways & Interactions for FAM71A Gene

SuperPathways for FAM71A Gene

No Data Available

Interacting Proteins for FAM71A Gene

Gene Ontology (GO) - Biological Process for FAM71A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM71A Gene

Drugs & Compounds for FAM71A Gene

No Compound Related Data Available

Transcripts for FAM71A Gene

mRNA/cDNA for FAM71A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM71A Gene

Family with sequence similarity 71, member A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM71A Gene

No ASD Table

Relevant External Links for FAM71A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM71A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM71A Gene

mRNA differential expression in normal tissues according to GTEx for FAM71A Gene

This gene is overexpressed in Testis (x49.4).

Protein differential expression in normal tissues from HIPED for FAM71A Gene

This gene is overexpressed in Testis (56.7) and Ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM71A Gene

Protein tissue co-expression partners for FAM71A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM71A Gene:


SOURCE GeneReport for Unigene cluster for FAM71A Gene:

genes like me logo Genes that share expression patterns with FAM71A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM71A Gene

Orthologs for FAM71A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM71A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM71A 33 34
  • 98.32 (n)
(Canis familiaris)
Mammalia FAM71A 33 34
  • 77.56 (n)
(Bos Taurus)
Mammalia FAM71A 33 34
  • 69.24 (n)
(Mus musculus)
Mammalia Fam71a 33 16 34
  • 68.82 (n)
(Rattus norvegicus)
Mammalia Fam71a 33
  • 68.47 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
-- 34
  • 44 (a)
Species where no ortholog for FAM71A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM71A Gene

Gene Tree for FAM71A (if available)
Gene Tree for FAM71A (if available)

Paralogs for FAM71A Gene

(2) SIMAP similar genes for FAM71A Gene using alignment to 2 proteins: Pseudogenes for FAM71A Gene

genes like me logo Genes that share paralogs with FAM71A: view

Variants for FAM71A Gene

Sequence variations from dbSNP and Humsavar for FAM71A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs767737768 likely-benign, Oromandibular-limb hypogenesis spectrum 212,626,342(+) T/C coding_sequence_variant, missense_variant
rs886037883 likely-benign, Oromandibular-limb hypogenesis spectrum 212,626,352(+) G/A/C coding_sequence_variant, missense_variant
rs1001758553 -- 212,624,022(+) A/G upstream_transcript_variant
rs1002202600 -- 212,625,938(+) A/T coding_sequence_variant, missense_variant
rs1002505237 -- 212,626,908(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM71A Gene

Variant ID Type Subtype PubMed ID
esv2758996 CNV loss 17122850
nsv549139 CNV gain 21841781

Variation tolerance for FAM71A Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.08; 90.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM71A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM71A Gene

Disorders for FAM71A Gene

Additional Disease Information for FAM71A

No disorders were found for FAM71A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM71A Gene

Publications for FAM71A Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology. (PMID: 26209634) Aizawa M … Fukuda M (The Journal of biological chemistry 2015) 3 58
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58

Products for FAM71A Gene

Sources for FAM71A Gene

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