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Aliases for FAM47A Gene

Aliases for FAM47A Gene

  • Family With Sequence Similarity 47 Member A 2 3 5
  • Family With Sequence Similarity 47, Member A 2
  • Similar To Hypothetical Protein FLJ35782 2
  • Protein FAM47A 3

External Ids for FAM47A Gene

Previous GeneCards Identifiers for FAM47A Gene

  • GC0XM033907
  • GC0XM031885

Summaries for FAM47A Gene

GeneCards Summary for FAM47A Gene

FAM47A (Family With Sequence Similarity 47 Member A) is a Protein Coding gene. An important paralog of this gene is FAM47C.

Additional gene information for FAM47A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM47A Gene

Genomics for FAM47A Gene

GeneHancer (GH) Regulatory Elements for FAM47A Gene

Promoters and enhancers for FAM47A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ033990 Enhancer 0.2 ENCODE 0.1 +142.2 142191 0.2 PIR31174 FAM47A LOC105373153
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM47A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM47A gene promoter:
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • HFH-3
  • FOXI1
  • POU2F2C
  • POU2F2B
  • POU2F2 (Oct-2.1)

Genomic Locations for FAM47A Gene

Genomic Locations for FAM47A Gene
2,579 bases
Minus strand
2,579 bases
Minus strand

Genomic View for FAM47A Gene

Genes around FAM47A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM47A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM47A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM47A Gene

Proteins for FAM47A Gene

  • Protein details for FAM47A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM47A
    Protein Accession:
    Secondary Accessions:
    • A8K8I9
    • Q8TAA0

    Protein attributes for FAM47A Gene

    791 amino acids
    Molecular mass:
    90592 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM47A Gene

Post-translational modifications for FAM47A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM47A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM47A Gene

Domains & Families for FAM47A Gene

Gene Families for FAM47A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM47A Gene


Suggested Antigen Peptide Sequences for FAM47A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM47 family.
  • Belongs to the FAM47 family.
genes like me logo Genes that share domains with FAM47A: view

Function for FAM47A Gene

Phenotypes From GWAS Catalog for FAM47A Gene

Phenotypes for FAM47A Gene

genes like me logo Genes that share phenotypes with FAM47A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM47A Gene

Localization for FAM47A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM47A gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM47A Gene

Pathways & Interactions for FAM47A Gene

SuperPathways for FAM47A Gene

No Data Available

Interacting Proteins for FAM47A Gene

Gene Ontology (GO) - Biological Process for FAM47A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM47A Gene

Drugs & Compounds for FAM47A Gene

No Compound Related Data Available

Transcripts for FAM47A Gene

mRNA/cDNA for FAM47A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM47A Gene

Family with sequence similarity 47, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM47A Gene

No ASD Table

Relevant External Links for FAM47A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM47A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM47A Gene

mRNA differential expression in normal tissues according to GTEx for FAM47A Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for FAM47A Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM47A Gene

Protein tissue co-expression partners for FAM47A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM47A Gene:


SOURCE GeneReport for Unigene cluster for FAM47A Gene:

genes like me logo Genes that share expression patterns with FAM47A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM47A Gene

Orthologs for FAM47A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM47A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM47A 33
  • 99.13 (n)
-- 34
  • 63 (a)
(Bos Taurus)
Mammalia FAM47A 33
  • 69.76 (n)
(Mus musculus)
Mammalia Fam47c 16 34 33
  • 61.96 (n)
4930480E11Rik 34
  • 27 (a)
4930402K13Rik 34
  • 21 (a)
(Rattus norvegicus)
Mammalia Fam47a 33
  • 59.9 (n)
(Canis familiaris)
Mammalia -- 34
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 27 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
-- 34
  • 23 (a)
(Danio rerio)
Actinopterygii zgc:158260 34 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4199 34
  • 20 (a)
Species where no ortholog for FAM47A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM47A Gene

Gene Tree for FAM47A (if available)
Gene Tree for FAM47A (if available)
Evolutionary constrained regions (ECRs) for FAM47A: view image

Paralogs for FAM47A Gene

Paralogs for FAM47A Gene

(2) SIMAP similar genes for FAM47A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM47A: view

Variants for FAM47A Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FAM47A Gene

The repeat encompassing Pro-495 to Glu-507 may be polymorphic.

Sequence variations from dbSNP and Humsavar for FAM47A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs373238471 benign, Abnormality of neuronal migration 34,130,969(-) G/A coding_sequence_variant, missense_variant
rs776397953 uncertain-significance, Abnormality of neuronal migration 34,132,152(-) T/C coding_sequence_variant, missense_variant
rs1001806022 -- 34,132,697(-) A/G upstream_transcript_variant
rs1002043248 -- 34,130,487(-) A/G coding_sequence_variant, missense_variant
rs1002068433 -- 34,132,365(-) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM47A Gene

Variant ID Type Subtype PubMed ID
esv2752322 CNV gain 17911159
nsv820274 CNV gain 19587683

Variation tolerance for FAM47A Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM47A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for FAM47A Gene

Additional Disease Information for FAM47A

No disorders were found for FAM47A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM47A Gene

Publications for FAM47A Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A … Kocher T (Journal of clinical periodontology 2013) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for FAM47A Gene

Sources for FAM47A Gene

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