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Aliases for FAM46B Gene

Aliases for FAM46B Gene

  • Family With Sequence Similarity 46 Member B 2 3 5
  • Family With Sequence Similarity 46, Member B 2
  • EC 2.7.7.- 4

External Ids for FAM46B Gene

Previous GeneCards Identifiers for FAM46B Gene

  • GC01M027204
  • GC01M027331
  • GC01M025584

Summaries for FAM46B Gene

GeneCards Summary for FAM46B Gene

FAM46B (Family With Sequence Similarity 46 Member B) is a Protein Coding gene. An important paralog of this gene is FAM46A.

UniProtKB/Swiss-Prot for FAM46B Gene

  • Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.

Additional gene information for FAM46B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM46B Gene

Genomics for FAM46B Gene

GeneHancer (GH) Regulatory Elements for FAM46B Gene

Promoters and enhancers for FAM46B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I027003 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +4.0 3957 10.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A YY1 POLR2B E2F8 FAM46B ARID1A HMGN2 LOC101928324 LOC101928728 RPL17P9 GPN2 ACTG1P20 WASF2 ENSG00000231344
GH01I026958 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.4 +52.0 52000 3.9 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 ELK1 GC01P026960 KDF1 PIGV NR0B2 NUDC FAM46B GPATCH3 ENSG00000226698 SFN LOC105376890
GH01I027614 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -613.0 -612996 23.4 HDGF PKNOX1 FOXA2 SMAD1 SIN3A YBX1 IRF4 ZNF121 ZNF207 ZNF143 FGR ACTG1P20 ARID1A EYA3 FAM76A TRNAU1AP NPM1P39 THEMIS2 PTAFR SNHG12
GH01I027487 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.1 -477.9 -477854 5.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 MCM3 WASF2 ARID1A ACTG1P20 GPN2 FAM76A PHACTR4 NPM1P39 MAP3K6 ENSG00000231344 LOC101928728
GH01I027516 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -511.0 -510971 13.7 ZFP64 DMAP1 YY1 ZNF548 ZNF263 MCM3 SP3 MEF2D SSRP1 GLIS1 LOC105376892 ARID1A ACTG1P20 MAP3K6 FAM76A PHACTR4 NPM1P39 EYA3 WASF2 GPN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM46B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM46B gene promoter:

Genomic Locations for FAM46B Gene

Genomic Locations for FAM46B Gene
7,823 bases
Minus strand

Genomic View for FAM46B Gene

Genes around FAM46B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM46B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM46B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM46B Gene

Proteins for FAM46B Gene

  • Protein details for FAM46B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative nucleotidyltransferase FAM46B
    Protein Accession:

    Protein attributes for FAM46B Gene

    425 amino acids
    Molecular mass:
    46688 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH12790.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13555.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FAM46B Gene

Post-translational modifications for FAM46B Gene

No Post-translational modifications

Other Protein References for FAM46B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM46B Gene

Domains & Families for FAM46B Gene

Gene Families for FAM46B Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FAM46B Gene


Suggested Antigen Peptide Sequences for FAM46B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM46 family.
  • Belongs to the FAM46 family.
genes like me logo Genes that share domains with FAM46B: view

Function for FAM46B Gene

Molecular function for FAM46B Gene

UniProtKB/Swiss-Prot Function:
Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.

Enzyme Numbers (IUBMB) for FAM46B Gene

Phenotypes From GWAS Catalog for FAM46B Gene

Gene Ontology (GO) - Molecular Function for FAM46B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with FAM46B: view
genes like me logo Genes that share phenotypes with FAM46B: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM46B Gene

Localization for FAM46B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM46B gene
Compartment Confidence
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM46B Gene

Pathways & Interactions for FAM46B Gene

SuperPathways for FAM46B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM46B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM46B Gene

Drugs & Compounds for FAM46B Gene

No Compound Related Data Available

Transcripts for FAM46B Gene

mRNA/cDNA for FAM46B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM46B Gene

Family with sequence similarity 46, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM46B Gene

No ASD Table

Relevant External Links for FAM46B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM46B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM46B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM46B Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.2), Esophagus - Mucosa (x4.8), Esophagus - Muscularis (x4.5), Skin - Not Sun Exposed (Suprapubic) (x4.5), and Esophagus - Gastroesophageal Junction (x4.1).

Protein differential expression in normal tissues from HIPED for FAM46B Gene

This gene is overexpressed in Urine (62.9) and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM46B Gene

Protein tissue co-expression partners for FAM46B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM46B Gene:


SOURCE GeneReport for Unigene cluster for FAM46B Gene:

genes like me logo Genes that share expression patterns with FAM46B: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM46B Gene

Orthologs for FAM46B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM46B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM46B 33 34
  • 99.45 (n)
(Bos Taurus)
Mammalia FAM46B 33 34
  • 89.57 (n)
(Canis familiaris)
Mammalia FAM46B 33 34
  • 89.25 (n)
(Mus musculus)
Mammalia Fam46b 33 16 34
  • 87.22 (n)
(Rattus norvegicus)
Mammalia Fam46b 33
  • 86.51 (n)
(Monodelphis domestica)
Mammalia FAM46B 34
  • 65 (a)
(Gallus gallus)
Aves FAM46B 34
  • 68 (a)
(Anolis carolinensis)
Reptilia FAM46B 34
  • 63 (a)
(Danio rerio)
Actinopterygii fam46ba 34
  • 67 (a)
fam46bb 34
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3131 33
fruit fly
(Drosophila melanogaster)
Insecta CG30497 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea pqn-44 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for FAM46B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM46B Gene

Gene Tree for FAM46B (if available)
Gene Tree for FAM46B (if available)

Paralogs for FAM46B Gene

Paralogs for FAM46B Gene

(4) SIMAP similar genes for FAM46B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM46B: view

Variants for FAM46B Gene

Sequence variations from dbSNP and Humsavar for FAM46B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000029318 -- 27,005,050(-) T/G 3_prime_UTR_variant
rs1000072607 -- 27,009,632(-) C/G intron_variant
rs1001668955 -- 27,005,703(-) A/G 3_prime_UTR_variant
rs1001747447 -- 27,008,189(-) G/A intron_variant
rs1001763769 -- 27,005,467(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM46B Gene

Variant ID Type Subtype PubMed ID
esv3585551 CNV gain 21293372
nsv1000012 CNV gain 25217958
nsv834535 CNV gain+loss 17160897

Variation tolerance for FAM46B Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM46B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM46B Gene

Disorders for FAM46B Gene

Additional Disease Information for FAM46B

No disorders were found for FAM46B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM46B Gene

Publications for FAM46B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases. (PMID: 27060136) Kuchta K … Ginalski K (Nucleic acids research 2016) 4 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for FAM46B Gene

Sources for FAM46B Gene

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