Aliases for FAM43B Gene

Aliases for FAM43B Gene

  • Family With Sequence Similarity 43 Member B 2 3 5
  • Protein FAM43B 3 4
  • Family With Sequence Similarity 43, Member B 2

External Ids for FAM43B Gene

Previous GeneCards Identifiers for FAM43B Gene

  • GC01P020624
  • GC01P020751
  • GC01P020878
  • GC01P019124

Summaries for FAM43B Gene

GeneCards Summary for FAM43B Gene

FAM43B (Family With Sequence Similarity 43 Member B) is a Protein Coding gene. An important paralog of this gene is FAM43A.

Additional gene information for FAM43B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM43B Gene

Genomics for FAM43B Gene

GeneHancer (GH) Regulatory Elements for FAM43B Gene

Promoters and enhancers for FAM43B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J020551 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 759.9 +0.1 115 2.5 NR2F6 CREB1 NFYC POLR2A ZNF148 HNF1A GLIS2 PRDM10 GATAD2A PATZ1 FAM43B MUL1 hsa-miR-5095-006
GH01J020554 Enhancer 0.4 Ensembl 750.6 +1.7 1662 0.2 RBPJ EZH2 ZFX FAM43B hsa-miR-5095-006
GH01J020474 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.7 -71.4 -71358 13.8 SIN3A ZBTB40 CTCF FOXA1 MLX RBPJ NR2F1 NR2F6 CREB1 MIXL1 CAMK2N1 ENSG00000284743 HP1BP3 OTUD3 MUL1 DDOST FAM43B ENSG00000226487 ENSG00000226664 LINC01757
GH01J021336 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +789.3 789326 10.1 ZNF785 SP1 ZBTB40 ZBTB6 FOXA1 MLX RBPJ SMARCE1 POLR2A NR2F1 ECE1 HP1BP3 NBPF3 NBPF2P USP48 HSPG2 LDLRAD2 CDC42-IT1 ENSG00000271428 FAM43B
GH01J020659 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.5 +108.9 108855 3 SP1 ZBTB40 CTCF ZBTB6 RBPJ POLR2A CEBPZ ATF1 FOS CREB1 DDOST lnc-PINK1-3 HP1BP3 SH2D5 PINK1 FAM43B MUL1 lnc-KIF17-2 KIF17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM43B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM43B gene promoter:
  • GATA-1
  • GATA-2
  • GATA-3
  • MIF-1
  • MyoD
  • Pax-4a
  • Pax-5
  • USF-1
  • USF-1:USF-2
  • XBP-1

Genomic Locations for FAM43B Gene

Genomic Locations for FAM43B Gene
chr1:20,552,439-20,555,020
(GRCh38/hg38)
Size:
2,582 bases
Orientation:
Plus strand
chr1:20,878,932-20,881,513
(GRCh37/hg19)
Size:
2,582 bases
Orientation:
Plus strand

Genomic View for FAM43B Gene

Genes around FAM43B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM43B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM43B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM43B Gene

Proteins for FAM43B Gene

  • Protein details for FAM43B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZT52-FA43B_HUMAN
    Recommended name:
    Protein FAM43B
    Protein Accession:
    Q6ZT52
    Secondary Accessions:
    • A5PKT8
    • A5PL01

    Protein attributes for FAM43B Gene

    Size:
    329 amino acids
    Molecular mass:
    36776 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM43B Gene

Post-translational modifications for FAM43B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM43B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM43B Gene

Domains & Families for FAM43B Gene

Gene Families for FAM43B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM43B Gene

Suggested Antigen Peptide Sequences for FAM43B Gene

GenScript: Design optimal peptide antigens:
  • Family with sequence similarity 43, member B (A5PKT8_HUMAN)
  • Protein FAM43B (FA43B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZT52

UniProtKB/Swiss-Prot:

FA43B_HUMAN :
  • Belongs to the FAM43 family.
Family:
  • Belongs to the FAM43 family.
genes like me logo Genes that share domains with FAM43B: view

Function for FAM43B Gene

Phenotypes From GWAS Catalog for FAM43B Gene

genes like me logo Genes that share phenotypes with FAM43B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM43B Gene

Localization for FAM43B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM43B gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM43B Gene

Pathways & Interactions for FAM43B Gene

PathCards logo

SuperPathways for FAM43B Gene

No Data Available

Interacting Proteins for FAM43B Gene

Gene Ontology (GO) - Biological Process for FAM43B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM43B Gene

Drugs & Compounds for FAM43B Gene

No Compound Related Data Available

Transcripts for FAM43B Gene

mRNA/cDNA for FAM43B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM43B Gene

No ASD Table

Relevant External Links for FAM43B Gene

GeneLoc Exon Structure for
FAM43B
ECgene alternative splicing isoforms for
FAM43B

Expression for FAM43B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM43B Gene

mRNA differential expression in normal tissues according to GTEx for FAM43B Gene

This gene is overexpressed in Adrenal Gland (x7.2).

Protein differential expression in normal tissues from HIPED for FAM43B Gene

This gene is overexpressed in Adipocyte (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM43B Gene



Protein tissue co-expression partners for FAM43B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM43B Gene:

FAM43B

SOURCE GeneReport for Unigene cluster for FAM43B Gene:

Hs.429179
genes like me logo Genes that share expression patterns with FAM43B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM43B Gene

Orthologs for FAM43B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM43B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM43B 33 32
  • 99.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM43B 33 32
  • 94.6 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam43b 32
  • 92.07 (n)
mouse
(Mus musculus)
Mammalia Fam43b 17 33 32
  • 91.77 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM43B 33
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM43B 33
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858896 32
  • 72.16 (n)
FAM43B 33
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam43b 33 32
  • 58.97 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8312 33
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52D10.2 33
  • 21 (a)
OneToMany
Species where no ortholog for FAM43B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAM43B Gene

ENSEMBL:
Gene Tree for FAM43B (if available)
TreeFam:
Gene Tree for FAM43B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM43B: view image

Paralogs for FAM43B Gene

(1) SIMAP similar genes for FAM43B Gene using alignment to 2 proteins:

  • FA43B_HUMAN
  • A5PKT8_HUMAN
genes like me logo Genes that share paralogs with FAM43B: view

Variants for FAM43B Gene

Sequence variations from dbSNP and Humsavar for FAM43B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000088146 -- 20,554,363(+) C/T 3_prime_UTR_variant
rs1000512705 -- 20,550,909(+) G/C upstream_transcript_variant
rs1000569514 -- 20,550,615(+) T/G upstream_transcript_variant
rs1000635603 -- 20,554,802(+) T/C 3_prime_UTR_variant
rs1001861541 -- 20,555,221(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM43B Gene

Variant ID Type Subtype PubMed ID
nsv1076225 CNV deletion 25765185
nsv545731 CNV gain 21841781

Variation tolerance for FAM43B Gene

Gene Damage Index Score: 0.53; 11.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM43B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM43B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM43B Gene

Disorders for FAM43B Gene

Additional Disease Information for FAM43B

No disorders were found for FAM43B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM43B Gene

Publications for FAM43B Gene

  1. Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines. (PMID: 21461611) Xu X … Han ZG (Molecular and cellular biochemistry 2011) 2 3 56
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for FAM43B Gene

Sources for FAM43B Gene