This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010] See more...

Aliases for FAM3C Gene

Aliases for FAM3C Gene

  • FAM3 Metabolism Regulating Signaling Molecule C 2 3
  • Family With Sequence Similarity 3 Member C 2 3 5
  • Interleukin-Like EMT Inducer 2 3 4
  • Interleukin-Like Epithelial-Mesenchymal Transition Inducer 2 3
  • Predicted Osteoblast Protein 2 3
  • Protein FAM3C 3 4
  • ILEI 3 4
  • GS3786 3

External Ids for FAM3C Gene

Previous GeneCards Identifiers for FAM3C Gene

  • GC07M119466
  • GC07M120529
  • GC07M120543
  • GC07M120582
  • GC07M120776
  • GC07M120988
  • GC07M115352

Summaries for FAM3C Gene

Entrez Gene Summary for FAM3C Gene

  • This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for FAM3C Gene

FAM3C (FAM3 Metabolism Regulating Signaling Molecule C) is a Protein Coding gene. Diseases associated with FAM3C include Deafness, Autosomal Recessive 17 and Pancreatic Cancer. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is FAM3D.

UniProtKB/Swiss-Prot Summary for FAM3C Gene

  • May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Gene Wiki entry for FAM3C Gene

Additional gene information for FAM3C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM3C Gene

Genomics for FAM3C Gene

GeneHancer (GH) Regulatory Elements for FAM3C Gene

Promoters and enhancers for FAM3C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J121393 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 504.8 +0.2 180 5.8 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC POLR2G USF1 FAM3C ING3 CYCSP19 lnc-WNT16-1 lnc-TSPAN12-6
GH07J121511 Promoter 0.7 EPDnew 500.1 -114.8 -114845 0.1 TRIM28 ZNF280A CBX5 SETDB1 KLF5 TAF1 ZBTB33 ZNF449 ZNF143 CBX3 FAM3C lnc-FAM3C-3 LOC105375478
GH07J121371 Enhancer 1.1 Ensembl ENCODE dbSUPER 23.2 +23.3 23269 3.8 CTCF SP1 EP300 JUND MEF2C BCL11A TCF12 ZNF316 CBFB ZNF384 FAM3C CYCSP19 lnc-TSPAN12-6
GH07J121417 Enhancer 0.8 Ensembl ENCODE 18.5 -23.6 -23573 4.5 ZNF217 CUX1 ZNF830 GATAD2B CTBP1 MBD2 NEUROD1 JUND GATA3 FOXA1 ENSG00000227371 lnc-WNT16-2 FAM3C CYCSP19 ENSG00000226636 piR-58297-453
GH07J121381 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +9.5 9468 11 HNRNPK ZBTB40 EP300 SIN3A SP1 RELA MEF2C ZNF740 REST TRIM22 FAM3C ING3 lnc-TSPAN12-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM3C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM3C

Top Transcription factor binding sites by QIAGEN in the FAM3C gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • HNF-3beta
  • NF-Y
  • NF-YA
  • NF-YC

Genomic Locations for FAM3C Gene

Genomic Locations for FAM3C Gene
chr7:121,348,245-121,396,369
(GRCh38/hg38)
Size:
48,125 bases
Orientation:
Minus strand
chr7:120,988,905-121,036,422
(GRCh37/hg19)
Size:
47,518 bases
Orientation:
Minus strand

Genomic View for FAM3C Gene

Genes around FAM3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3C Gene

Proteins for FAM3C Gene

  • Protein details for FAM3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92520-FAM3C_HUMAN
    Recommended name:
    Protein FAM3C
    Protein Accession:
    Q92520
    Secondary Accessions:
    • A6NDN2
    • A8K3R7

    Protein attributes for FAM3C Gene

    Size:
    227 amino acids
    Molecular mass:
    24680 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Up-regulation and/or mislocalization in breast cancer and liver carcinoma cells is strongly correlated with metastasis formation and survival.

    Three dimensional structures from OCA and Proteopedia for FAM3C Gene

neXtProt entry for FAM3C Gene

Post-translational modifications for FAM3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM3C Gene

No data available for DME Specific Peptides for FAM3C Gene

Domains & Families for FAM3C Gene

Gene Families for FAM3C Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FAM3C Gene

Suggested Antigen Peptide Sequences for FAM3C Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-like EMT inducer (FAM3C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92520

UniProtKB/Swiss-Prot:

FAM3C_HUMAN :
  • Belongs to the FAM3 family.
Family:
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3C: view

Function for FAM3C Gene

Molecular function for FAM3C Gene

UniProtKB/Swiss-Prot Function:
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.

Phenotypes From GWAS Catalog for FAM3C Gene

Gene Ontology (GO) - Molecular Function for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 12160727
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM3C: view
genes like me logo Genes that share phenotypes with FAM3C: view

Animal Models for FAM3C Gene

MGI Knock Outs for FAM3C:
  • Fam3c Fam3c<tm1.1Lex>
  • Fam3c Fam3c<tm2(FAM3C)Lex>

Animal Model Products

CRISPR Products

miRNA for FAM3C Gene

miRTarBase miRNAs that target FAM3C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM3C Gene

Localization for FAM3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3C Gene

Secreted. Cytoplasmic vesicle. Note=Cytoplasmic in some cancer cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM3C gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005794 Golgi apparatus IDA --
GO:0031089 platelet dense granule lumen TAS --
GO:0031410 cytoplasmic vesicle IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with FAM3C: view

Pathways & Interactions for FAM3C Gene

genes like me logo Genes that share pathways with FAM3C: view

Gene Ontology (GO) - Biological Process for FAM3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
GO:0045721 negative regulation of gluconeogenesis IEA --
genes like me logo Genes that share ontologies with FAM3C: view

No data available for SIGNOR curated interactions for FAM3C Gene

Drugs & Compounds for FAM3C Gene

No Compound Related Data Available

Transcripts for FAM3C Gene

mRNA/cDNA for FAM3C Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3C Gene

No ASD Table

Relevant External Links for FAM3C Gene

GeneLoc Exon Structure for
FAM3C

Expression for FAM3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM3C Gene

This gene is overexpressed in Bone (38.8) and Cerebrospinal fluid (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM3C Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM3C

SOURCE GeneReport for Unigene cluster for FAM3C Gene:

Hs.434053

mRNA Expression by UniProt/SwissProt for FAM3C Gene:

Q92520-FAM3C_HUMAN
Tissue specificity: Present in most secretory epithelia (at protein level).

Evidence on tissue expression from TISSUES for FAM3C Gene

  • Nervous system(4.6)
  • Intestine(4.5)
  • Liver(4.4)
  • Muscle(4.3)
  • Bone(4.2)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with FAM3C: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM3C Gene

Orthologs for FAM3C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM3C 31 30
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM3C 31 30
  • 94.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM3C 31 30
  • 93.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM3C 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam3c 17 31 30
  • 88.25 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM3C 31
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam3c 30
  • 86.64 (n)
chicken
(Gallus gallus)
Aves FAM3C 31 30
  • 84.43 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM3C 31
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3c 30
  • 78.67 (n)
Str.17429 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.29483 30
zebrafish
(Danio rerio)
Actinopterygii fam3c 31 30
  • 65.56 (n)
OneToOne
Dr.4343 30
worm
(Caenorhabditis elegans)
Secernentea M70.4 31
  • 8 (a)
ManyToMany
Y73B3A.3 31
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 31
  • 32 (a)
OneToMany
Species where no ortholog for FAM3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3C Gene

ENSEMBL:
Gene Tree for FAM3C (if available)
TreeFam:
Gene Tree for FAM3C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM3C: view image

Paralogs for FAM3C Gene

Paralogs for FAM3C Gene

(3) SIMAP similar genes for FAM3C Gene using alignment to 3 proteins:

  • FAM3C_HUMAN
  • C9JMN4_HUMAN
  • C9JP35_HUMAN
genes like me logo Genes that share paralogs with FAM3C: view

Variants for FAM3C Gene

Additional dbSNP identifiers (rs#s) for FAM3C Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM3C Gene

Variant ID Type Subtype PubMed ID
esv2759558 CNV loss 17122850
nsv1034353 CNV loss 25217958
nsv7405 OTHER inversion 18451855

Variation tolerance for FAM3C Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM3C Gene

Human Gene Mutation Database (HGMD)
FAM3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM3C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM3C Gene

Disorders for FAM3C Gene

MalaCards: The human disease database

(4) MalaCards diseases for FAM3C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 17
  • dfnb17
pancreatic cancer
  • pancreatic carcinoma
intestinal obstruction
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search FAM3C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FAM3C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FAM3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM3C Gene

Publications for FAM3C Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y … Young PR (Genomics 2002) 2 3 4 23 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. (PMID: 19396169) Cho YS … Kim HL (Nature genetics 2009) 3 41 54
  4. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PMID: 16406369) Guo J … Yu L (FEBS letters 2006) 3 23 54
  5. ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. (PMID: 16959614) Waerner T … Beug H (Cancer cell 2006) 3 4 54

Products for FAM3C Gene

Sources for FAM3C Gene