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Aliases for FAM32A Gene

Aliases for FAM32A Gene

  • Family With Sequence Similarity 32 Member A 2 3 5
  • Ovarian Tumor Associated Gene-12 2 3
  • OTAG-12 3 4
  • OTAG12 3 4
  • Family With Sequence Similarity 32, Member A 2
  • Ovarian Tumor-Associated Gene 12 4
  • Protein FAM32A 3

External Ids for FAM32A Gene

Previous GeneCards Identifiers for FAM32A Gene

  • GC19P016157
  • GC19P016297
  • GC19P015867
  • GC19P016301
  • GC19P016431
  • GC19P017106
  • GC19P017362
  • GC19P017894
  • GC19P016574
  • GC19P016811
  • GC19P017589
  • GC19P018257
  • GC19P018657
  • GC19P018965
  • GC19P019290
  • GC19P019619

Summaries for FAM32A Gene

GeneCards Summary for FAM32A Gene

FAM32A (Family With Sequence Similarity 32 Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FAM32A Gene

  • Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.

Gene Wiki entry for FAM32A Gene

Additional gene information for FAM32A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM32A Gene

Genomics for FAM32A Gene

GeneHancer (GH) Regulatory Elements for FAM32A Gene

Promoters and enhancers for FAM32A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J016184 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.5 472 1.9 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 POLR2B ZNF213 E2F8 ZNF143 ENSG00000275901 FAM32A MED26 HAUS8 CHERP AKAP8 C19orf44 BRD4 ENSG00000268743 AP1M1
GH19J016091 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 12.1 -89.9 -89926 7.6 FOXA2 ARID4B DMAP1 ZNF48 ETS1 POLR2B ATF7 RXRA SP5 KAT8 HSH2D CIB3 FAM32A EPS15L1 RAB8A ENSG00000267373 ENSG00000279198 TPM4
GH19J016148 Enhancer 1 Ensembl ENCODE dbSUPER 13.8 -35.5 -35517 2.9 CEBPB ZMYM3 OSR2 ATF4 POLR2A ZFP36 ETV6 MLLT1 RUNX3 SPI1 CIB3 FAM32A AP1M1 ENSG00000269243 HSH2D
GH19J016040 Enhancer 1 Ensembl ENCODE 11.8 -144.0 -143953 1.5 ELF3 RB1 ARID4B IRF4 ZNF48 RAD21 YY1 ZNF335 ZNF121 ZNF143 GC19P020261 GC19P020303 GC19P020306 GC19P020318 GC19P020335 GC19P020348 GC19P020357 GC19P020361 GC19P020373 GC19P020374
GH19J016195 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.2 +13.0 13002 6.1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B AP1M1 GC19M016194 C19orf44 ENSG00000141979 FAM32A GC19M016236
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM32A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM32A gene promoter:
  • POU3F2
  • LUN-1
  • AML1a
  • Pbx1a
  • GATA-2
  • C/EBPalpha
  • RFX1
  • POU6F1 (c2)
  • Pax-3
  • SREBP-1c

Genomic Locations for FAM32A Gene

Genomic Locations for FAM32A Gene
6,863 bases
Plus strand
6,667 bases
Plus strand

Genomic View for FAM32A Gene

Genes around FAM32A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM32A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM32A Gene

Proteins for FAM32A Gene

  • Protein details for FAM32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM32A
    Protein Accession:
    Secondary Accessions:
    • Q9BT02

    Protein attributes for FAM32A Gene

    112 amino acids
    Molecular mass:
    13178 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM32A Gene


neXtProt entry for FAM32A Gene

Post-translational modifications for FAM32A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM32A Gene

No data available for DME Specific Peptides for FAM32A Gene

Domains & Families for FAM32A Gene

Gene Families for FAM32A Gene

Protein Domains for FAM32A Gene

Suggested Antigen Peptide Sequences for FAM32A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM32 family.
  • Belongs to the FAM32 family.
genes like me logo Genes that share domains with FAM32A: view

Function for FAM32A Gene

Molecular function for FAM32A Gene

UniProtKB/Swiss-Prot Function:
Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
UniProtKB/Swiss-Prot Induction:
By etoposide, puromycin or carboplatin.

Gene Ontology (GO) - Molecular Function for FAM32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with FAM32A: view
genes like me logo Genes that share phenotypes with FAM32A: view

Animal Model Products

miRNA for FAM32A Gene

miRTarBase miRNAs that target FAM32A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM32A Gene

Localization for FAM32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM32A Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM32A gene
Compartment Confidence
nucleus 5
mitochondrion 3
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IBA,IDA --
genes like me logo Genes that share ontologies with FAM32A: view

Pathways & Interactions for FAM32A Gene

SuperPathways for FAM32A Gene

No Data Available

Interacting Proteins for FAM32A Gene

Gene Ontology (GO) - Biological Process for FAM32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM32A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM32A Gene

Drugs & Compounds for FAM32A Gene

No Compound Related Data Available

Transcripts for FAM32A Gene

mRNA/cDNA for FAM32A Gene

Unigene Clusters for FAM32A Gene

Family with sequence similarity 32, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM32A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP2: -
SP3: -
SP4: - -

Relevant External Links for FAM32A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM32A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM32A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM32A Gene

This gene is overexpressed in Plasma (19.1), Blymphocyte (15.1), Lung (6.6), CD8 Tcells (6.6), and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM32A Gene

Protein tissue co-expression partners for FAM32A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM32A Gene:


SOURCE GeneReport for Unigene cluster for FAM32A Gene:


mRNA Expression by UniProt/SwissProt for FAM32A Gene:

Tissue specificity: Expressed in ovary, with isoform 1 being predominant.

Evidence on tissue expression from TISSUES for FAM32A Gene

  • Nervous system(4.7)
  • Lung(4.4)
  • Liver(2)
genes like me logo Genes that share expression patterns with FAM32A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM32A Gene

Orthologs for FAM32A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM32A Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia FAM32A 34
  • 100 (a)
(Pan troglodytes)
Mammalia FAM32A 34 33
  • 99.7 (n)
(Bos Taurus)
Mammalia FAM32A 34 33
  • 93.75 (n)
(Canis familiaris)
Mammalia FAM32A 34 33
  • 93.45 (n)
(Rattus norvegicus)
Mammalia Fam32a 33
  • 89.58 (n)
(Mus musculus)
Mammalia Fam32a 16 34 33
  • 88.69 (n)
(Monodelphis domestica)
Mammalia FAM32A 34
  • 85 (a)
(Gallus gallus)
Aves FAM32A 33
  • 78.68 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam32a 33
  • 68.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13214 33
(Danio rerio)
Actinopterygii fam32al 34
  • 71 (a)
fam32a 33
  • 66.97 (n)
wufc30d06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9554 33
fruit fly
(Drosophila melanogaster)
Insecta CG15432 34
  • 46 (a)
Species where no ortholog for FAM32A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM32A Gene

Gene Tree for FAM32A (if available)
Gene Tree for FAM32A (if available)
Evolutionary constrained regions (ECRs) for FAM32A: view image

Paralogs for FAM32A Gene

genes like me logo Genes that share paralogs with FAM32A: view

No data available for Paralogs for FAM32A Gene

Variants for FAM32A Gene

Sequence variations from dbSNP and Humsavar for FAM32A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000025908 -- 16,184,018(+) C/G upstream_transcript_variant
rs1000028752 -- 16,187,286(+) C/G/T intron_variant
rs1000059785 -- 16,186,989(+) G/A intron_variant
rs1000480301 -- 16,187,989(+) A/C/G intron_variant
rs1000949260 -- 16,187,415(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM32A Gene

Variant ID Type Subtype PubMed ID
nsv833767 CNV loss 17160897

Variation tolerance for FAM32A Gene

Gene Damage Index Score: 0.52; 11.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM32A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM32A Gene

Disorders for FAM32A Gene

Additional Disease Information for FAM32A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM32A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM32A Gene

Publications for FAM32A Gene

  1. Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization. (PMID: 21339736) Chen X … Sairam MR (Oncogene 2011) 2 3 4 58
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for FAM32A Gene

Sources for FAM32A Gene

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