Aliases for FAM32A Gene

Aliases for FAM32A Gene

  • Family With Sequence Similarity 32 Member A 2 3 5
  • Ovarian Tumor Associated Gene-12 2 3
  • Protein FAM32A 3 4
  • OTAG-12 3 4
  • OTAG12 3 4
  • Family With Sequence Similarity 32, Member A 2
  • Ovarian Tumor-Associated Gene 12 4

External Ids for FAM32A Gene

Previous GeneCards Identifiers for FAM32A Gene

  • GC19P016157
  • GC19P016297
  • GC19P015867
  • GC19P016301
  • GC19P016431
  • GC19P017106
  • GC19P017362
  • GC19P017894
  • GC19P016574
  • GC19P016811
  • GC19P020441
  • GC19P020578
  • GC19P017589
  • GC19P018257
  • GC19P018657
  • GC19P018965
  • GC19P019290
  • GC19P019619
  • GC19P019982
  • GC19P020297

Summaries for FAM32A Gene

GeneCards Summary for FAM32A Gene

FAM32A (Family With Sequence Similarity 32 Member A) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for FAM32A Gene

  • Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.

Gene Wiki entry for FAM32A Gene

Additional gene information for FAM32A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM32A Gene

Genomics for FAM32A Gene

GeneHancer (GH) Regulatory Elements for FAM32A Gene

Promoters and enhancers for FAM32A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM32A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM32A gene promoter:
  • AML1a
  • C/EBPalpha
  • GATA-2
  • LUN-1
  • Pax-3
  • Pbx1a
  • POU3F2
  • POU6F1 (c2)
  • RFX1
  • SREBP-1c

Genomic Locations for FAM32A Gene

Genomic Locations for FAM32A Gene
6,863 bases
Plus strand
6,667 bases
Plus strand

Genomic View for FAM32A Gene

Genes around FAM32A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM32A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM32A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM32A Gene

Proteins for FAM32A Gene

  • Protein details for FAM32A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM32A
    Protein Accession:
    Secondary Accessions:
    • Q9BT02

    Protein attributes for FAM32A Gene

    112 amino acids
    Molecular mass:
    13178 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FAM32A Gene

    Alternative splice isoforms for FAM32A Gene


neXtProt entry for FAM32A Gene

Post-translational modifications for FAM32A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM32A Gene

No data available for DME Specific Peptides for FAM32A Gene

Domains & Families for FAM32A Gene

Gene Families for FAM32A Gene

Protein Domains for FAM32A Gene

Suggested Antigen Peptide Sequences for FAM32A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM32A (FA32A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM32 family.
  • Belongs to the FAM32 family.
genes like me logo Genes that share domains with FAM32A: view

Function for FAM32A Gene

Molecular function for FAM32A Gene

UniProtKB/Swiss-Prot Function:
Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
UniProtKB/Swiss-Prot Induction:
By etoposide, puromycin or carboplatin.

Gene Ontology (GO) - Molecular Function for FAM32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with FAM32A: view
genes like me logo Genes that share phenotypes with FAM32A: view

Animal Model Products

CRISPR Products

miRNA for FAM32A Gene

miRTarBase miRNAs that target FAM32A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM32A Gene

Localization for FAM32A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM32A Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM32A gene
Compartment Confidence
nucleus 5
mitochondrion 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IBA,IDA --
genes like me logo Genes that share ontologies with FAM32A: view

Pathways & Interactions for FAM32A Gene

PathCards logo

SuperPathways for FAM32A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM32A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM32A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM32A Gene

Drugs & Compounds for FAM32A Gene

No Compound Related Data Available

Transcripts for FAM32A Gene

mRNA/cDNA for FAM32A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM32A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP2: -
SP3: -
SP4: - -

Relevant External Links for FAM32A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM32A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM32A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM32A Gene

This gene is overexpressed in Plasma (19.1), Blymphocyte (15.1), Lung (6.6), CD8 Tcells (6.6), and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM32A Gene

Protein tissue co-expression partners for FAM32A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM32A Gene:


SOURCE GeneReport for Unigene cluster for FAM32A Gene:


mRNA Expression by UniProt/SwissProt for FAM32A Gene:

Tissue specificity: Expressed in ovary, with isoform 1 being predominant.

Evidence on tissue expression from TISSUES for FAM32A Gene

  • Nervous system(4.7)
  • Lung(4.4)
  • Liver(2)
genes like me logo Genes that share expression patterns with FAM32A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM32A Gene

Orthologs for FAM32A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM32A Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia FAM32A 33
  • 100 (a)
(Pan troglodytes)
Mammalia FAM32A 33 32
  • 99.7 (n)
(Bos Taurus)
Mammalia FAM32A 33 32
  • 93.75 (n)
(Canis familiaris)
Mammalia FAM32A 33 32
  • 93.45 (n)
(Rattus norvegicus)
Mammalia Fam32a 32
  • 89.58 (n)
(Mus musculus)
Mammalia Fam32a 17 33 32
  • 88.69 (n)
(Monodelphis domestica)
Mammalia FAM32A 33
  • 85 (a)
(Gallus gallus)
Aves FAM32A 32
  • 78.68 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam32a 32
  • 68.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13214 32
(Danio rerio)
Actinopterygii fam32al 33
  • 71 (a)
fam32a 32
  • 66.97 (n)
wufc30d06 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9554 32
fruit fly
(Drosophila melanogaster)
Insecta CG15432 33
  • 46 (a)
Species where no ortholog for FAM32A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM32A Gene

Gene Tree for FAM32A (if available)
Gene Tree for FAM32A (if available)
Evolutionary constrained regions (ECRs) for FAM32A: view image

Paralogs for FAM32A Gene

genes like me logo Genes that share paralogs with FAM32A: view

No data available for Paralogs for FAM32A Gene

Variants for FAM32A Gene

Sequence variations from dbSNP and Humsavar for FAM32A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000025908 -- 16,184,018(+) C/G upstream_transcript_variant
rs1000028752 -- 16,187,286(+) C/G/T intron_variant
rs1000059785 -- 16,186,989(+) G/A intron_variant
rs1000480301 -- 16,187,989(+) A/C/G intron_variant
rs1000949260 -- 16,187,415(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM32A Gene

Variant ID Type Subtype PubMed ID
nsv833767 CNV loss 17160897

Variation tolerance for FAM32A Gene

Gene Damage Index Score: 0.52; 11.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM32A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM32A Gene

Disorders for FAM32A Gene

Additional Disease Information for FAM32A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM32A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM32A Gene

Publications for FAM32A Gene

  1. Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization. (PMID: 21339736) Chen X … Sairam MR (Oncogene 2011) 2 3 4 56
  2. A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. (PMID: 30705154) Fica SM … Nagai K (Science (New York, N.Y.) 2019) 2 3 56
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 56

Products for FAM32A Gene

Sources for FAM32A Gene