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Aliases for FAM25A Gene

Aliases for FAM25A Gene

  • Family With Sequence Similarity 25 Member A 2 3 5
  • Family With Sequence Similarity 25, Member A 2
  • Protein FAM25A 3
  • Protein FAM25 3
  • BA96C23.5 3

External Ids for FAM25A Gene

Previous GeneCards Identifiers for FAM25A Gene

  • GC10U900468
  • GC10P047872
  • GC10P088776
  • GC10P082633
  • GC10P088784
  • GC10P088787
  • GC10P088793
  • GC10P088798
  • GC10P088806

Summaries for FAM25A Gene

GeneCards Summary for FAM25A Gene

FAM25A (Family With Sequence Similarity 25 Member A) is a Protein Coding gene. An important paralog of this gene is FAM25G.

Additional gene information for FAM25A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM25A Gene

Genomics for FAM25A Gene

GeneHancer (GH) Regulatory Elements for FAM25A Gene

Promoters and enhancers for FAM25A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I087020 Promoter 0.7 EPDnew 550.8 0.0 -14 0.1 ZNF687 FOS FAM25A ENSG00000229969 ENSG00000272508 GC10P086949
GH10I087019 Enhancer 0.4 ENCODE 550.8 -0.8 -830 0.2 PKNOX1 NFIC NFIB FAM25A SNCG ENSG00000229969 ENSG00000272508 GC10P086949
GH10I087021 Enhancer 0.4 ENCODE 550.8 -0.4 -414 0.6 PKNOX1 ZNF687 FOS FAM25A ENSG00000229969 ENSG00000272508 GC10P086949
GH10I087017 Enhancer 0.5 Ensembl 0.8 -2.8 -2788 0.2 SMARCE1 ESRRA RFX1 FOS ENSG00000229969 FAM25A ENSG00000272508 GC10P086949
GH10I087024 Enhancer 1 Ensembl ENCODE 0.4 +5.5 5538 1.8 HDAC1 ZNF335 FOS ATF7 ZBTB2 NCOA1 ELF1 ATF4 MTA1 SMARCA4 ENSG00000271573 NUTM2D PAPSS2 GLUD1 FAM25A GC10P086949
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM25A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM25A gene promoter:

Genomic Locations for FAM25A Gene

Genomic Locations for FAM25A Gene
chr10:87,020,289-87,024,730
(GRCh38/hg38)
Size:
4,442 bases
Orientation:
Plus strand
chr10:88,780,046-88,784,487
(GRCh37/hg19)

Genomic View for FAM25A Gene

Genes around FAM25A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM25A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM25A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM25A Gene

Proteins for FAM25A Gene

  • Protein details for FAM25A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B3EWG3-FM25A_HUMAN
    Recommended name:
    Protein FAM25A
    Protein Accession:
    B3EWG3
    Secondary Accessions:
    • B2RV02
    • Q5VTM1

    Protein attributes for FAM25A Gene

    Size:
    89 amino acids
    Molecular mass:
    9320 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI17119.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM25A Gene

Post-translational modifications for FAM25A Gene

No Post-translational modifications

Other Protein References for FAM25A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM25A Gene

Domains & Families for FAM25A Gene

Gene Families for FAM25A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM25A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

B3EWG3

UniProtKB/Swiss-Prot:

FM25A_HUMAN :
  • Belongs to the FAM25 family.
Family:
  • Belongs to the FAM25 family.
genes like me logo Genes that share domains with FAM25A: view

No data available for Suggested Antigen Peptide Sequences for FAM25A Gene

Function for FAM25A Gene

Phenotypes for FAM25A Gene

GenomeRNAi human phenotypes for FAM25A:
genes like me logo Genes that share phenotypes with FAM25A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM25A Gene

Localization for FAM25A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM25A gene
Compartment Confidence
cytosol 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM25A Gene

Pathways & Interactions for FAM25A Gene

SuperPathways for FAM25A Gene

No Data Available

Interacting Proteins for FAM25A Gene

Gene Ontology (GO) - Biological Process for FAM25A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM25A Gene

Drugs & Compounds for FAM25A Gene

No Compound Related Data Available

Transcripts for FAM25A Gene

mRNA/cDNA for FAM25A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM25A Gene

Family with sequence similarity 25, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM25A Gene

No ASD Table

Relevant External Links for FAM25A Gene

GeneLoc Exon Structure for
FAM25A
ECgene alternative splicing isoforms for
FAM25A

Expression for FAM25A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM25A Gene

mRNA differential expression in normal tissues according to GTEx for FAM25A Gene

This gene is overexpressed in Esophagus - Mucosa (x22.8), Cervix - Ectocervix (x8.0), Vagina (x7.1), Skin - Sun Exposed (Lower leg) (x6.3), and Skin - Not Sun Exposed (Suprapubic) (x4.9).

Protein differential expression in normal tissues from HIPED for FAM25A Gene

This gene is overexpressed in Cervix (54.8) and Saliva (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM25A Gene



Protein tissue co-expression partners for FAM25A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM25A Gene:

FAM25A

SOURCE GeneReport for Unigene cluster for FAM25A Gene:

Hs.729945
genes like me logo Genes that share expression patterns with FAM25A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM25A Gene

Orthologs for FAM25A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM25A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam25c 34
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
Species where no ortholog for FAM25A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM25A Gene

ENSEMBL:
Gene Tree for FAM25A (if available)
TreeFam:
Gene Tree for FAM25A (if available)

Paralogs for FAM25A Gene

Paralogs for FAM25A Gene

(5) SIMAP similar genes for FAM25A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM25A: view

Variants for FAM25A Gene

Sequence variations from dbSNP and Humsavar for FAM25A Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000007170 -- 87,020,525(+) C/T intron_variant
rs1000080450 -- 87,020,354(+) C/A/T coding_sequence_variant, synonymous_variant
rs1001686919 -- 87,021,946(+) G/A intron_variant
rs1002019008 -- 87,023,568(+) A/T intron_variant
rs1002094049 -- 87,023,220(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM25A Gene

Variant ID Type Subtype PubMed ID
nsv948111 CNV duplication 23825009
nsv8712 CNV loss 18304495
nsv831939 CNV gain 17160897
nsv428236 CNV loss 18775914
nsv1141879 OTHER inversion 24896259
esv2759774 CNV gain+loss 17122850
esv27213 CNV loss 19812545

Variation tolerance for FAM25A Gene

Gene Damage Index Score: 3.20; 52.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM25A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM25A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM25A Gene

Disorders for FAM25A Gene

Additional Disease Information for FAM25A

No disorders were found for FAM25A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM25A Gene

Publications for FAM25A Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for FAM25A Gene

Sources for FAM25A Gene

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