Aliases for FAM241B Gene

Aliases for FAM241B Gene

  • Family With Sequence Similarity 241 Member B 2 3 5
  • Protein FAM241B 3 4
  • C10orf35 3 4
  • Chromosome 10 Open Reading Frame 35 2
  • Uncharacterized Protein C10orf35 3

External Ids for FAM241B Gene

Previous HGNC Symbols for FAM241B Gene

  • C10orf35

Summaries for FAM241B Gene

GeneCards Summary for FAM241B Gene

FAM241B (Family With Sequence Similarity 241 Member B) is a Protein Coding gene. An important paralog of this gene is FAM241A.

UniProtKB/Swiss-Prot Summary for FAM241B Gene

Additional gene information for FAM241B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM241B Gene

Genomics for FAM241B Gene

GeneHancer (GH) Regulatory Elements for FAM241B Gene

Promoters and enhancers for FAM241B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J069629 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 521.9 +0.4 357 2 HNRNPK ZNF217 EP300 CTCF NRF1 USF1 PHF8 PHB2 ZFX ZNF639 FAM241B ENSG00000236154 NEUROG3 COL13A1 lnc-FAM241B-4
GH10J069572 Promoter 0.7 EPDnew 500.2 -57.3 -57304 0.1 ZBTB26 SP2 ZFHX2 ZNF777 ELF1 ZNF335 RNF2 SUZ12 EZH2 EGR2 LOC101929021 NEUROG3 FAM241B MG828474
GH10J069315 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 -311.5 -311545 7.2 HNRNPK EP300 SIN3A JUND PHF8 PHB2 ZFX ZNF10 ZBTB5 ZIC2 HK1 DDX21 DDX50 TYSND1 CCAR1 HNRNPH3 ENSG00000231748 HKDC1 FAM241B piR-50437-063
GH10J069445 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -180.7 -180650 9 CTCF TCF12 SP1 JUND FOS ZFX ZIC2 ZBTB10 FOXA1 NR3C1 TSPAN15 HSALNG0078579 DDX50 CCAR1 DDX21 FAM241B VPS26A TACR2 AIFM2 piR-31199-034
GH10J069683 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +55.0 54964 3.8 NCOR1 MXI1 ZSCAN9 NR2F2 CREB1 ZBTB33 JUND RCOR1 RAD21 RXRA FAM241B lnc-NEUROG3-7 LINC02651 HSALNG0078604
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM241B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM241B

Genomic Locations for FAM241B Gene

Genomic Locations for FAM241B Gene
chr10:69,630,243-69,633,599
(GRCh38/hg38)
Size:
3,357 bases
Orientation:
Plus strand
chr10:71,390,003-71,393,355
(GRCh37/hg19)
Size:
3,353 bases
Orientation:
Plus strand

Genomic View for FAM241B Gene

Genes around FAM241B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM241B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM241B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM241B Gene

Proteins for FAM241B Gene

  • Protein details for FAM241B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D05-F241B_HUMAN
    Recommended name:
    Protein FAM241B
    Protein Accession:
    Q96D05

    Protein attributes for FAM241B Gene

    Size:
    121 amino acids
    Molecular mass:
    13238 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM241B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM241B Gene

Post-translational modifications for FAM241B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM241B Gene

No data available for DME Specific Peptides for FAM241B Gene

Domains & Families for FAM241B Gene

Gene Families for FAM241B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM241B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96D05

UniProtKB/Swiss-Prot:

F241B_HUMAN :
  • Belongs to the FAM241 family.
Family:
  • Belongs to the FAM241 family.
genes like me logo Genes that share domains with FAM241B: view

No data available for Suggested Antigen Peptide Sequences for FAM241B Gene

Function for FAM241B Gene

Molecular function for FAM241B Gene

UniProtKB/Swiss-Prot Function:
May play a role in lysosome homeostasis.

Phenotypes From GWAS Catalog for FAM241B Gene

Gene Ontology (GO) - Molecular Function for FAM241B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM241B: view
genes like me logo Genes that share phenotypes with FAM241B: view

miRNA for FAM241B Gene

miRTarBase miRNAs that target FAM241B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM241B Gene

Localization for FAM241B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM241B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM241B gene
Compartment Confidence
plasma membrane 2
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM241B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA 21873635
genes like me logo Genes that share ontologies with FAM241B: view

Pathways & Interactions for FAM241B Gene

PathCards logo

SuperPathways for FAM241B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM241B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM241B Gene

Drugs & Compounds for FAM241B Gene

No Compound Related Data Available

Transcripts for FAM241B Gene

mRNA/cDNA for FAM241B Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM241B Gene

No ASD Table

Relevant External Links for FAM241B Gene

GeneLoc Exon Structure for
FAM241B

Expression for FAM241B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM241B

Evidence on tissue expression from TISSUES for FAM241B Gene

  • Pancreas(4.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM241B Gene

Orthologs for FAM241B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM241B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10orf35 31
  • 100 (a)
OneToOne
C10H10orf35 30
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia C28H10ORF35 31
  • 94 (a)
OneToOne
C28H10orf35 30
  • 89.44 (n)
dog
(Canis familiaris)
Mammalia C10orf35 31
  • 93 (a)
OneToOne
C4H10orf35 30
  • 90 (n)
mouse
(Mus musculus)
Mammalia 2010107G23Rik 31 30
  • 85.56 (n)
OneToOne
Fam241b 17
rat
(Rattus norvegicus)
Mammalia RGD1305587 30
  • 85.28 (n)
oppossum
(Monodelphis domestica)
Mammalia C10orf35 31
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf35 31
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf35 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf35 30
  • 64.1 (n)
Str.16059 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7113 30
Species where no ortholog for FAM241B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM241B Gene

ENSEMBL:
Gene Tree for FAM241B (if available)
TreeFam:
Gene Tree for FAM241B (if available)

Paralogs for FAM241B Gene

Paralogs for FAM241B Gene

genes like me logo Genes that share paralogs with FAM241B: view

Variants for FAM241B Gene

Additional dbSNP identifiers (rs#s) for FAM241B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM241B Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
nsv509356 CNV insertion 20534489
nsv7032 CNV insertion 18451855

Variation tolerance for FAM241B Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM241B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM241B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM241B Gene

Disorders for FAM241B Gene

Additional Disease Information for FAM241B

No disorders were found for FAM241B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM241B Gene

Publications for FAM241B Gene

  1. CRISPR knockout screen implicates three genes in lysosome function. (PMID: 31270356) Lenk GM … Kitzman JO (Scientific reports 2019) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for FAM241B Gene

Sources for FAM241B Gene