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Aliases for FAM234A Gene

Aliases for FAM234A Gene

  • Family With Sequence Similarity 234 Member A 2 3 5
  • Integrin Alpha FG-GAP Repeat Containing 3 2 3
  • Protein ITFG3 3 4
  • C16orf9 3 4
  • ITFG3 3 4
  • Family With Sequence Similarity 234, Member A 2
  • Chromosome 16 Open Reading Frame 9 2
  • Protein FAM234A 3
  • Gs19 3

External Ids for FAM234A Gene

Previous HGNC Symbols for FAM234A Gene

  • C16orf9
  • ITFG3

Previous GeneCards Identifiers for FAM234A Gene

  • GC16P000319
  • GC16P000328
  • GC16P000354
  • GC16P000359
  • GC16P000390
  • GC16P000412

Summaries for FAM234A Gene

GeneCards Summary for FAM234A Gene

FAM234A (Family With Sequence Similarity 234 Member A) is a Protein Coding gene. An important paralog of this gene is ENSG00000269881.

Gene Wiki entry for FAM234A Gene

Additional gene information for FAM234A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM234A Gene

Genomics for FAM234A Gene

GeneHancer (GH) Regulatory Elements for FAM234A Gene

Promoters and enhancers for FAM234A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I000233 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 558.4 +0.4 403 2.9 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B FAM234A WDR90 LUC7L RHOT2 ENSG00000268836 JMJD8 WASH4P ENSG00000228779 WDR24 LMF1
GH16I000323 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +91.9 91886 5.3 PKNOX1 CLOCK ARNT NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 LUC7L WDR90 ENSG00000228779 RHOT2 UBE2I ENSG00000261505 WDR24 JMJD8 ENSG00000262528 TMEM8A
GH16I000227 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.3 -5.6 -5561 2.1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 POLR2B LUC7L LOC105371184 ENSG00000262528 FAM234A GC16M000218 LOC102723930 GC16P000130
GH16I000252 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.4 +18.3 18258 1.6 HDGF HDAC1 ARNT NFRKB ZBTB40 EGR1 IKZF2 RUNX3 ZBTB2 ZEB2 PIR53440 LOC100129478 LUC7L FAM234A HBM HBZ ARHGDIG ENSG00000269881 GC16P000130
GH16I000180 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 8.1 -53.4 -53447 1.9 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 ZNF207 ZNF143 KLF13 HBQ1 WDR90 RHOT2 WASH4P WDR24 JMJD8 ENSG00000268836 ENSG00000260022 AXIN1 LMF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM234A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM234A Gene

Genomic Locations for FAM234A Gene
chr16:234,546-269,943
(GRCh38/hg38)
Size:
35,398 bases
Orientation:
Plus strand
chr16:284,545-319,942
(GRCh37/hg19)

Genomic View for FAM234A Gene

Genes around FAM234A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM234A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM234A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM234A Gene

Proteins for FAM234A Gene

  • Protein details for FAM234A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0X4-F234A_HUMAN
    Recommended name:
    Protein FAM234A
    Protein Accession:
    Q9H0X4
    Secondary Accessions:
    • D3DU45
    • Q7L416
    • Q96FR1
    • Q96MC7
    • Q96S30

    Protein attributes for FAM234A Gene

    Size:
    552 amino acids
    Molecular mass:
    59660 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK61220.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM234A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM234A Gene

Post-translational modifications for FAM234A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM234A Gene

Domains & Families for FAM234A Gene

Gene Families for FAM234A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM234A Gene

Suggested Antigen Peptide Sequences for FAM234A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0X4

UniProtKB/Swiss-Prot:

F234A_HUMAN :
  • Belongs to the FAM234 family.
Family:
  • Belongs to the FAM234 family.
genes like me logo Genes that share domains with FAM234A: view

Function for FAM234A Gene

Phenotypes From GWAS Catalog for FAM234A Gene

Gene Ontology (GO) - Molecular Function for FAM234A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM234A: view
genes like me logo Genes that share phenotypes with FAM234A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM234A Gene

Localization for FAM234A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM234A Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM234A gene
Compartment Confidence
extracellular 5
plasma membrane 3
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM234A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 19349973
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA,HDA 20458337
genes like me logo Genes that share ontologies with FAM234A: view

Pathways & Interactions for FAM234A Gene

SuperPathways for FAM234A Gene

No Data Available

Interacting Proteins for FAM234A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301678%0d%0a9606.ENSP00000363054%0d%0a
Selected Interacting proteins: Q9H0X4-F234A_HUMAN ENSP00000301678 for FAM234A Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM234A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM234A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM234A Gene

Drugs & Compounds for FAM234A Gene

No Compound Related Data Available

Transcripts for FAM234A Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM234A Gene

No ASD Table

Relevant External Links for FAM234A Gene

GeneLoc Exon Structure for
FAM234A
ECgene alternative splicing isoforms for
FAM234A

Expression for FAM234A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FAM234A Gene:

FAM234A

Evidence on tissue expression from TISSUES for FAM234A Gene

  • Nervous system(4.7)
  • Intestine(4.3)
  • Liver(4.2)
  • Stomach(4.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with FAM234A: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM234A Gene

Orthologs for FAM234A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM234A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITFG3 33
  • 97.95 (n)
-- 34
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Itfg3 33 34
  • 77.62 (n)
Fam234a 16
dog
(Canis familiaris)
Mammalia ITFG3 33
  • 77.37 (n)
-- 34
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Itfg3 33
  • 77.11 (n)
cow
(Bos Taurus)
Mammalia ITFG3 33 34
  • 75.32 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves ITFG3 33
  • 57.72 (n)
-- 34
  • 51 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia itfg3 33
  • 52.42 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC796439 33
  • 46.56 (n)
ITFG3 34
  • 30 (a)
OneToMany
Species where no ortholog for FAM234A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM234A Gene

ENSEMBL:
Gene Tree for FAM234A (if available)
TreeFam:
Gene Tree for FAM234A (if available)

Paralogs for FAM234A Gene

Paralogs for FAM234A Gene

genes like me logo Genes that share paralogs with FAM234A: view

Variants for FAM234A Gene

Sequence variations from dbSNP and Humsavar for FAM234A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000036133 -- 252,854(+) G/A intron_variant
rs1000195165 -- 264,669(+) T/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000250465 -- 238,346(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000299354 -- 268,363(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000357181 -- 246,027(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM234A Gene

Variant ID Type Subtype PubMed ID
nsv977893 CNV duplication 23825009
nsv827477 CNV gain 20364138
nsv518291 CNV loss 19592680
nsv1147155 CNV insertion 26484159
nsv1140309 OTHER inversion 24896259
nsv1120315 CNV tandem duplication 24896259
nsv1120314 CNV tandem duplication 24896259
nsv1070307 CNV deletion 25765185
nsv1044142 CNV gain 25217958
esv3637563 CNV gain 21293372
esv3637562 CNV gain 21293372
esv3637561 CNV loss 21293372
esv3637560 CNV loss 21293372
esv3637559 CNV loss 21293372
esv3637558 CNV loss 21293372
esv3570031 CNV gain 25503493
esv3393842 CNV duplication 20981092
esv2961 CNV loss 18987735
esv2667528 CNV deletion 23128226
esv2660459 CNV deletion 23128226
esv2422427 CNV duplication 17116639
esv1473294 CNV insertion 17803354
dgv32n68 CNV loss 17160897
dgv1479e59 CNV duplication 20981092

Variation tolerance for FAM234A Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM234A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM234A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM234A Gene

Disorders for FAM234A Gene

No disorders were found for FAM234A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM234A Gene

Publications for FAM234A Gene

  1. Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. (PMID: 19349973) Wollscheid B … Watts JD (Nature biotechnology 2009) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for FAM234A Gene

Sources for FAM234A Gene

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