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Aliases for FAM229B Gene

Aliases for FAM229B Gene

  • Family With Sequence Similarity 229 Member B 2 3 5
  • C6orf225 3 4
  • Family With Sequence Similarity 229, Member B 2
  • Chromosome 6 Open Reading Frame 225 2
  • UPF0731 Protein C6orf225 3
  • Protein FAM229B 3

External Ids for FAM229B Gene

Previous HGNC Symbols for FAM229B Gene

  • C6orf225

Previous GeneCards Identifiers for FAM229B Gene

  • GC06P112409

Summaries for FAM229B Gene

GeneCards Summary for FAM229B Gene

FAM229B (Family With Sequence Similarity 229 Member B) is a Protein Coding gene. An important paralog of this gene is FAM229A.

Additional gene information for FAM229B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM229B Gene

Genomics for FAM229B Gene

GeneHancer (GH) Regulatory Elements for FAM229B Gene

Promoters and enhancers for FAM229B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J112086 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.1 -70 2 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 FAM229B TUBE1 WISP3 ENSG00000237234
GH06J112041 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -43.5 -43506 4.4 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 ZNF207 WISP3 ENSG00000255389 FAM229B TRAF3IP2-AS1 TUBE1 FYN TRAF3IP2 GC06M111982
GH06J112036 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -48.8 -48813 4.1 FOXA2 JUN ZIC2 OSR2 E2F1 GATA3 JUND POLR2A ZNF692 ZNF629 WISP3 FAM229B TRAF3IP2 FYN TUBE1 GC06M111982
GH06J112149 Enhancer 1 FANTOM5 ENCODE dbSUPER 13.7 +62.7 62742 2 ZSCAN4 KLF4 ZFHX2 POLR2A SCRT2 ZSCAN5C RCOR1 WT1 CHD2 ZBTB17 TUBE1 FAM229B ENSG00000255389 ENSG00000237234 LAMA4
GH06J112153 Enhancer 0.9 ENCODE dbSUPER 15.1 +68.0 68048 3.4 ZNF384 ZNF664 FOSL1 ZNF316 POLR2A SCRT2 ZSCAN5C PRDM10 NFE2 FOSL2 ENSG00000237234 TUBE1 FAM229B GC06M112197 RNU6-1226P LAMA4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM229B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM229B Gene

Genomic Locations for FAM229B Gene
chr6:112,087,471-112,102,790
(GRCh38/hg38)
Size:
15,320 bases
Orientation:
Plus strand
chr6:112,408,674-112,423,993
(GRCh37/hg19)
Size:
15,320 bases
Orientation:
Plus strand

Genomic View for FAM229B Gene

Genes around FAM229B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM229B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM229B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM229B Gene

Proteins for FAM229B Gene

  • Protein details for FAM229B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0N7-F229B_HUMAN
    Recommended name:
    Protein FAM229B
    Protein Accession:
    Q4G0N7
    Secondary Accessions:
    • B8ZZ33

    Protein attributes for FAM229B Gene

    Size:
    80 amino acids
    Molecular mass:
    8717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM229B Gene

Post-translational modifications for FAM229B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM229B Gene

No data available for DME Specific Peptides for FAM229B Gene

Domains & Families for FAM229B Gene

Gene Families for FAM229B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM229B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM229B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0N7

UniProtKB/Swiss-Prot:

F229B_HUMAN :
  • Belongs to the FAM229 family.
Family:
  • Belongs to the FAM229 family.
genes like me logo Genes that share domains with FAM229B: view

Function for FAM229B Gene

Phenotypes for FAM229B Gene

genes like me logo Genes that share phenotypes with FAM229B: view

Animal Model Products

miRNA for FAM229B Gene

miRTarBase miRNAs that target FAM229B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM229B Gene

Localization for FAM229B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM229B gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM229B Gene

Pathways & Interactions for FAM229B Gene

SuperPathways for FAM229B Gene

No Data Available

Interacting Proteins for FAM229B Gene

Gene Ontology (GO) - Biological Process for FAM229B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM229B Gene

Drugs & Compounds for FAM229B Gene

No Compound Related Data Available

Transcripts for FAM229B Gene

mRNA/cDNA for FAM229B Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM229B Gene

Family with sequence similarity 229, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM229B Gene

No ASD Table

Relevant External Links for FAM229B Gene

GeneLoc Exon Structure for
FAM229B
ECgene alternative splicing isoforms for
FAM229B

Expression for FAM229B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM229B Gene

mRNA differential expression in normal tissues according to GTEx for FAM229B Gene

This gene is overexpressed in Testis (x8.7) and Brain - Spinal cord (cervical c-1) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM229B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM229B Gene



Protein tissue co-expression partners for FAM229B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM229B Gene:

FAM229B

SOURCE GeneReport for Unigene cluster for FAM229B Gene:

Hs.591340

Evidence on tissue expression from TISSUES for FAM229B Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with FAM229B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM229B Gene

Orthologs for FAM229B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM229B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf225 33
  • 97.92 (n)
FAM229B 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM229B 34
  • 94 (a)
OneToOne
C12H6orf225 33
  • 93.75 (n)
cow
(Bos Taurus)
Mammalia FAM229B 34 33
  • 90.83 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam229b 33
  • 90.42 (n)
mouse
(Mus musculus)
Mammalia Fam229b 16 34 33
  • 89.58 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM229B 34
  • 86 (a)
OneToOne
Species where no ortholog for FAM229B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM229B Gene

ENSEMBL:
Gene Tree for FAM229B (if available)
TreeFam:
Gene Tree for FAM229B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM229B: view image

Paralogs for FAM229B Gene

Paralogs for FAM229B Gene

(1) SIMAP similar genes for FAM229B Gene using alignment to 1 proteins:

  • F229B_HUMAN
genes like me logo Genes that share paralogs with FAM229B: view

Variants for FAM229B Gene

Sequence variations from dbSNP and Humsavar for FAM229B Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000085628 -- 112,089,430(+) T/G intron_variant
rs1000288557 -- 112,102,831(+) A/G downstream_transcript_variant
rs1000385038 -- 112,096,056(+) A/T intron_variant
rs1000735222 -- 112,100,930(+) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1001127249 -- 112,094,371(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM229B Gene

Variant ID Type Subtype PubMed ID
nsv950495 CNV duplication 24416366
esv3610388 CNV loss 21293372
esv3571360 CNV loss 25503493
esv28804 CNV loss 19812545
esv2676434 CNV deletion 23128226

Variation tolerance for FAM229B Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM229B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM229B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM229B Gene

Disorders for FAM229B Gene

Additional Disease Information for FAM229B

No disorders were found for FAM229B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM229B Gene

Publications for FAM229B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for FAM229B Gene

Sources for FAM229B Gene

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