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Aliases for FAM228A Gene

Aliases for FAM228A Gene

  • Family With Sequence Similarity 228 Member A 2 3 5
  • Protein FAM228A 3 4
  • C2orf84 3 4
  • Family With Sequence Similarity 228, Member A 2
  • Chromosome 2 Open Reading Frame 84 2
  • UPF0638 Protein C2orf84 3

External Ids for FAM228A Gene

Previous HGNC Symbols for FAM228A Gene

  • C2orf84

Previous GeneCards Identifiers for FAM228A Gene

  • GC02P024399

Summaries for FAM228A Gene

GeneCards Summary for FAM228A Gene

FAM228A (Family With Sequence Similarity 228 Member A) is a Protein Coding gene. An important paralog of this gene is FAM228B.

Additional gene information for FAM228A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM228A Gene

Genomics for FAM228A Gene

GeneHancer (GH) Regulatory Elements for FAM228A Gene

Promoters and enhancers for FAM228A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J024075 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.2 -98.2 -98170 3.7 CC2D1A SP1 ZFX ELF3 MNT SIX5 NKRF POLR2A CEBPG RERE FAM228B GC02M024079 PIR43014 SF3B6 FAM228A ATAD2B TP53I3 PFN4 ITSN2 WDCP
GH02J024121 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 605.1 -51.7 -51679 4.5 HDGF ZFX SP1 NKRF POLR2A RERE ZNF687 ZSCAN21 TFE3 NCOA6 FAM228B PFN4 FAM228A ENSG00000276087 ATAD2B WDCP ENSG00000271936 CENPO MFSD2B UBXN2A
GH02J024175 Promoter 1.2 EPDnew Ensembl 642.3 +0.5 457 1.4 ZBTB33 L3MBTL2 FAM228A ENSG00000232642 LOC105374328 TP53I3 ENSG00000223754 ENSG00000276087 GC02P023754
GH02J024303 Enhancer 0.9 Ensembl ENCODE 27.2 +129.5 129477 1.8 SP1 RXRA CEBPA FOXA2 JUND FOS YY1 ZBTB33 GABPA GATA3 FAM228A ENSG00000251805 ITSN2 ENSG00000242628 GC02M024302 PIR31330 HMGN2P20 GC02P023754
GH02J024164 Enhancer 0.8 Ensembl 21.9 -10.2 -10242 3.6 CC2D1A CTCF CEBPG ZNF384 ZNF644 IKZF1 KAT8 ARID2 IKZF2 GATAD2A FAM228A ENSG00000232642 FAM228B LOC105374328 ENSG00000276087 GC02P023754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM228A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM228A Gene

Genomic Locations for FAM228A Gene
25,807 bases
Plus strand
25,781 bases
Plus strand

Genomic View for FAM228A Gene

Genes around FAM228A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM228A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM228A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM228A Gene

Proteins for FAM228A Gene

  • Protein details for FAM228A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM228A
    Protein Accession:

    Protein attributes for FAM228A Gene

    206 amino acids
    Molecular mass:
    23752 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM228A Gene

Post-translational modifications for FAM228A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM228A Gene

No data available for DME Specific Peptides for FAM228A Gene

Domains & Families for FAM228A Gene

Gene Families for FAM228A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM228A Gene


Suggested Antigen Peptide Sequences for FAM228A Gene

GenScript: Design optimal peptide antigens:
  • UPF0638 protein C2orf84 (CB084_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM228 family.
  • Belongs to the FAM228 family.
genes like me logo Genes that share domains with FAM228A: view

Function for FAM228A Gene

Phenotypes From GWAS Catalog for FAM228A Gene

Phenotypes for FAM228A Gene

genes like me logo Genes that share phenotypes with FAM228A: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FAM228A - Now 50% OFF >
  • * FAM228A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FAM228A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM228A Gene

Localization for FAM228A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM228A Gene

Pathways & Interactions for FAM228A Gene

PathCards logo

SuperPathways for FAM228A Gene

No Data Available

Interacting Proteins for FAM228A Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
Selected Interacting proteins: ENSP00000295150 for FAM228A Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM228A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM228A Gene

Drugs & Compounds for FAM228A Gene

No Compound Related Data Available

Transcripts for FAM228A Gene

mRNA/cDNA for FAM228A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for FAM228A Gene

Family with sequence similarity 228, member A:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FAM228A - Now 50% OFF >
  • * FAM228A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FAM228A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FAM228A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for FAM228A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM228A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM228A Gene

mRNA differential expression in normal tissues according to GTEx for FAM228A Gene

This gene is overexpressed in Testis (x29.1).

Protein differential expression in normal tissues from HIPED for FAM228A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM228A Gene

Protein tissue co-expression partners for FAM228A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM228A Gene:


SOURCE GeneReport for Unigene cluster for FAM228A Gene:

genes like me logo Genes that share expression patterns with FAM228A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM228A Gene

Orthologs for FAM228A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM228A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM228A 35 34
  • 99.03 (n)
(Bos Taurus)
Mammalia FAM228A 35 34
  • 72.16 (n)
(Mus musculus)
Mammalia Fam228a 17 35 34
  • 65.08 (n)
(Rattus norvegicus)
Mammalia Fam228a 34
  • 63.98 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 15 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 13 (a)
-- 35
  • 6 (a)
(Gallus gallus)
Aves -- 35
  • 11 (a)
(Danio rerio)
Actinopterygii fam228a 35
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 8 (a)
Species where no ortholog for FAM228A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM228A Gene

Gene Tree for FAM228A (if available)
Gene Tree for FAM228A (if available)
Evolutionary constrained regions (ECRs) for FAM228A: view image

Paralogs for FAM228A Gene

Paralogs for FAM228A Gene

(1) SIMAP similar genes for FAM228A Gene using alignment to 4 proteins:

  • F228A_HUMAN
  • F2Z3J0_HUMAN
  • H7C3M9_HUMAN
  • H7C4B8_HUMAN
genes like me logo Genes that share paralogs with FAM228A: view

Variants for FAM228A Gene

Sequence variations from dbSNP and Humsavar for FAM228A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000857158 -- 24,177,568(+) G/A/T intron_variant
rs1000882387 -- 24,184,441(+) T/C/G intron_variant
rs1000913495 -- 24,184,228(+) A/G intron_variant
rs1000915235 -- 24,189,847(+) C/T intron_variant
rs1000971770 -- 24,190,007(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM228A Gene

Variant ID Type Subtype PubMed ID
esv3583669 CNV loss 25503493
esv3590063 CNV loss 21293372
nsv455897 CNV gain 19166990
nsv581179 CNV gain 21841781
nsv997445 CNV gain 25217958
nsv997725 CNV gain 25217958

Variation tolerance for FAM228A Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM228A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM228A Gene

Disorders for FAM228A Gene

Additional Disease Information for FAM228A

No disorders were found for FAM228A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM228A Gene

Publications for FAM228A Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N … Trégouët DA (BMC medical genetics 2013) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for FAM228A Gene

Sources for FAM228A Gene

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