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Aliases for FAM228A Gene

Aliases for FAM228A Gene

  • Family With Sequence Similarity 228 Member A 2 3 5
  • C2orf84 3 4
  • Family With Sequence Similarity 228, Member A 2
  • Chromosome 2 Open Reading Frame 84 2
  • UPF0638 Protein C2orf84 3
  • Protein FAM228A 3

External Ids for FAM228A Gene

Previous HGNC Symbols for FAM228A Gene

  • C2orf84

Previous GeneCards Identifiers for FAM228A Gene

  • GC02P024399

Summaries for FAM228A Gene

GeneCards Summary for FAM228A Gene

FAM228A (Family With Sequence Similarity 228 Member A) is a Protein Coding gene. An important paralog of this gene is FAM228B.

Additional gene information for FAM228A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM228A Gene

Genomics for FAM228A Gene

GeneHancer (GH) Regulatory Elements for FAM228A Gene

Promoters and enhancers for FAM228A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I024175 Promoter 0.6 EPDnew 550.8 +0.0 20 0.1 ZBTB33 FAM228A LOC105374328 ENSG00000223754 ENSG00000276087 GC02P023754
GH02I024303 Enhancer 0.9 Ensembl ENCODE 27.2 +129.5 129477 1.8 FOXA2 MAX CEBPG RAD21 RARA YY1 GATA3 FOS RXRA BHLHE40 FAM228A ENSG00000251805 ITSN2 ENSG00000242628 GC02M024302 PIR31330 HMGN2P20 GC02P023754
GH02I024339 Enhancer 0.9 Ensembl dbSUPER 27 +164.8 164758 1.2 ELF3 ESRRA FOXA2 RARA NR2F6 GATAD2A RXRA NR2F1 HLF CEBPB FAM228A ITSN2 RPL36AP13 GC02P023754
GH02I024164 Enhancer 0.8 Ensembl 20.8 -10.4 -10393 0.7 RB1 ARID4B ZNF48 RAD21 ARID2 ZNF143 IKZF2 CREM THAP11 SMARCA5 FAM228A LOC105374328 ENSG00000276087 FAM228B GC02P023754
GH02I024358 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 6.5 +184.9 184887 3.1 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 POLR2B ITSN2 LOC105374328 ATAD2B DNMT3A FAM228A TP53I3 RPL36AP13 GC02P023754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM228A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM228A Gene

Genomic Locations for FAM228A Gene
chr2:24,175,043-24,200,849
(GRCh38/hg38)
Size:
25,807 bases
Orientation:
Plus strand
chr2:24,397,938-24,423,718
(GRCh37/hg19)

Genomic View for FAM228A Gene

Genes around FAM228A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM228A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM228A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM228A Gene

Proteins for FAM228A Gene

  • Protein details for FAM228A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W67-F228A_HUMAN
    Recommended name:
    Protein FAM228A
    Protein Accession:
    Q86W67

    Protein attributes for FAM228A Gene

    Size:
    206 amino acids
    Molecular mass:
    23752 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM228A Gene

Post-translational modifications for FAM228A Gene

No Post-translational modifications

Other Protein References for FAM228A Gene

No data available for DME Specific Peptides for FAM228A Gene

Domains & Families for FAM228A Gene

Gene Families for FAM228A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM228A Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM228A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86W67

UniProtKB/Swiss-Prot:

F228A_HUMAN :
  • Belongs to the FAM228 family.
Family:
  • Belongs to the FAM228 family.
genes like me logo Genes that share domains with FAM228A: view

Function for FAM228A Gene

Phenotypes From GWAS Catalog for FAM228A Gene

Phenotypes for FAM228A Gene

GenomeRNAi human phenotypes for FAM228A:
genes like me logo Genes that share phenotypes with FAM228A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM228A Gene

Localization for FAM228A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM228A Gene

Pathways & Interactions for FAM228A Gene

SuperPathways for FAM228A Gene

No Data Available

Interacting Proteins for FAM228A Gene

Gene Ontology (GO) - Biological Process for FAM228A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM228A Gene

Drugs & Compounds for FAM228A Gene

No Compound Related Data Available

Transcripts for FAM228A Gene

mRNA/cDNA for FAM228A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM228A Gene

Family with sequence similarity 228, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM228A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for FAM228A Gene

GeneLoc Exon Structure for
FAM228A
ECgene alternative splicing isoforms for
FAM228A

Expression for FAM228A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM228A Gene

mRNA differential expression in normal tissues according to GTEx for FAM228A Gene

This gene is overexpressed in Testis (x29.1).

Protein differential expression in normal tissues from HIPED for FAM228A Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM228A Gene



Protein tissue co-expression partners for FAM228A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM228A Gene:

FAM228A

SOURCE GeneReport for Unigene cluster for FAM228A Gene:

Hs.741736
genes like me logo Genes that share expression patterns with FAM228A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM228A Gene

Orthologs for FAM228A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM228A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM228A 33 34
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia FAM228A 33 34
  • 72.16 (n)
mouse
(Mus musculus)
Mammalia Fam228a 33 16 34
  • 65.08 (n)
rat
(Rattus norvegicus)
Mammalia Fam228a 33
  • 63.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 15 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 13 (a)
ManyToMany
-- 34
  • 6 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 11 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fam228a 34
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 8 (a)
OneToMany
Species where no ortholog for FAM228A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM228A Gene

ENSEMBL:
Gene Tree for FAM228A (if available)
TreeFam:
Gene Tree for FAM228A (if available)

Paralogs for FAM228A Gene

Paralogs for FAM228A Gene

(1) SIMAP similar genes for FAM228A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM228A: view

Variants for FAM228A Gene

Sequence variations from dbSNP and Humsavar for FAM228A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000857158 -- 24,177,568(+) G/A/T intron_variant
rs1000882387 -- 24,184,441(+) T/C/G intron_variant
rs1000913495 -- 24,184,228(+) A/G intron_variant
rs1000915235 -- 24,189,847(+) C/T intron_variant
rs1000971770 -- 24,190,007(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM228A Gene

Variant ID Type Subtype PubMed ID
nsv997725 CNV gain 25217958
nsv997445 CNV gain 25217958
nsv581179 CNV gain 21841781
nsv455897 CNV gain 19166990
esv3590063 CNV loss 21293372
esv3583669 CNV loss 25503493

Variation tolerance for FAM228A Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM228A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM228A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM228A Gene

Disorders for FAM228A Gene

Additional Disease Information for FAM228A

No disorders were found for FAM228A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM228A Gene

Publications for FAM228A Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N … Trégouët DA (BMC medical genetics 2013) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for FAM228A Gene

Sources for FAM228A Gene

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