Aliases for FAM227B Gene

Aliases for FAM227B Gene

  • Family With Sequence Similarity 227 Member B 2 3 5
  • Protein FAM227B 3 4
  • C15orf33 3 4
  • Family With Sequence Similarity 227, Member B 2
  • Chromosome 15 Open Reading Frame 33 2
  • FLJ32800 2
  • FAM227B 5

External Ids for FAM227B Gene

Previous HGNC Symbols for FAM227B Gene

  • C15orf33

Previous GeneCards Identifiers for FAM227B Gene

  • GC15M049619

Summaries for FAM227B Gene

GeneCards Summary for FAM227B Gene

FAM227B (Family With Sequence Similarity 227 Member B) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM227B Gene

Genomics for FAM227B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM227B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM227B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM227B

Genomic Locations for FAM227B Gene

Latest Assembly
chr15:49,326,962-49,620,931
(GRCh38/hg38)
Size:
293,970 bases
Orientation:
Minus strand

Previous Assembly
chr15:49,619,167-49,913,015
(GRCh37/hg19 by Entrez Gene)
Size:
293,849 bases
Orientation:
Minus strand

chr15:49,619,159-49,913,128
(GRCh37/hg19 by Ensembl)
Size:
293,970 bases
Orientation:
Minus strand

Genomic View for FAM227B Gene

Genes around FAM227B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM227B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM227B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM227B Gene

Proteins for FAM227B Gene

  • Protein details for FAM227B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M60-F227B_HUMAN
    Recommended name:
    Protein FAM227B
    Protein Accession:
    Q96M60
    Secondary Accessions:
    • Q86WS2

    Protein attributes for FAM227B Gene

    Size:
    508 amino acids
    Molecular mass:
    59956 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM227B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM227B Gene

Post-translational modifications for FAM227B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM227B Gene

Domains & Families for FAM227B Gene

Gene Families for FAM227B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM227B Gene

InterPro:

Graphical View of Domain Structure for InterPro Entry

Q96M60

UniProtKB/Swiss-Prot:

F227B_HUMAN :
  • Belongs to the FAM227 family.
Family:
  • Belongs to the FAM227 family.
genes like me logo Genes that share domains with FAM227B: view

No data available for Suggested Antigen Peptide Sequences for FAM227B Gene

Function for FAM227B Gene

Phenotypes From GWAS Catalog for FAM227B Gene

genes like me logo Genes that share phenotypes with FAM227B: view

miRNA for FAM227B Gene

miRTarBase miRNAs that target FAM227B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM227B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM227B Gene

Localization for FAM227B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM227B gene
Compartment Confidence
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM227B Gene

Pathways & Interactions for FAM227B Gene

PathCards logo

SuperPathways for FAM227B Gene

No Data Available

Interacting Proteins for FAM227B Gene

Selected Interacting proteins: Q96M60-F227B_HUMAN for FAM227B Gene via IID

Symbol External ID(s) Details
RAB3A

Gene Ontology (GO) - Biological Process for FAM227B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM227B Gene

Drugs & Compounds for FAM227B Gene

No Compound Related Data Available

Transcripts for FAM227B Gene

mRNA/cDNA for FAM227B Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM227B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM227B Gene

No ASD Table

Relevant External Links for FAM227B Gene

GeneLoc Exon Structure for
FAM227B

Expression for FAM227B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM227B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM227B

SOURCE GeneReport for Unigene cluster for FAM227B Gene:

Hs.712959
genes like me logo Genes that share expression patterns with FAM227B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM227B Gene

Orthologs for FAM227B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM227B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM227B 29 30
  • 98.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM227B 29 30
  • 84.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM227B 29
  • 82.05 (n)
Rat
(Rattus norvegicus)
Mammalia Fam227b 29
  • 74.8 (n)
Mouse
(Mus musculus)
Mammalia Fam227b 29 16 30
  • 74.27 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM227B 30
  • 49 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM227B 30
  • 44 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM227B 30
  • 37 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam227b 29
  • 54.31 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 30 (a)
OneToOne
Species where no ortholog for FAM227B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FAM227B Gene

ENSEMBL:
Gene Tree for FAM227B (if available)
TreeFam:
Gene Tree for FAM227B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM227B: view image
Alliance of Genome Resources:
Additional Orthologs for FAM227B

Paralogs for FAM227B Gene

(2) SIMAP similar genes for FAM227B Gene using alignment to 7 proteins:

  • F227B_HUMAN
  • H0YK12_HUMAN
  • H0YLL2_HUMAN
  • H0YLX5_HUMAN
  • H0YMU4_HUMAN
  • H0YMX9_HUMAN
  • H0YNN2_HUMAN
genes like me logo Genes that share paralogs with FAM227B: view

No data available for Paralogs for FAM227B Gene

Variants for FAM227B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM227B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM227B Gene

Variant ID Type Subtype PubMed ID
esv2664633 CNV deletion 23128226
esv27180 CNV loss 19812545
esv2749672 CNV deletion 23290073
esv3581695 CNV loss 25503493
esv3581696 CNV loss 25503493
esv3636426 CNV loss 21293372
esv3636427 CNV loss 21293372
esv3636428 CNV gain 21293372
esv3636429 CNV loss 21293372
esv3636430 CNV loss 21293372
nsv1039185 CNV loss 25217958
nsv1040578 CNV loss 25217958
nsv1043119 CNV loss 25217958
nsv1154137 CNV duplication 26484159
nsv442375 CNV loss 18776908
nsv476356 CNV novel sequence insertion 20440878
nsv476436 CNV novel sequence insertion 20440878
nsv526246 CNV loss 19592680
nsv569392 CNV loss 21841781
nsv819023 CNV loss 19587683
nsv833002 CNV gain 17160897
nsv9263 CNV gain 18304495
nsv974651 CNV duplication 23825009
nsv976934 CNV duplication 23825009
nsv984069 CNV duplication 23825009

Variation tolerance for FAM227B Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM227B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM227B
Leiden Open Variation Database (LOVD)
FAM227B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM227B Gene

Disorders for FAM227B Gene

Additional Disease Information for FAM227B

No disorders were found for FAM227B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM227B Gene

Publications for FAM227B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  4. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. (PMID: 23408906) Porcu E … Naitza S (PLoS genetics 2013) 3
  5. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. (PMID: 21565293) Teumer A … Völzke H (American journal of human genetics 2011) 3

Products for FAM227B Gene

Sources for FAM227B Gene