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Aliases for FAM227A Gene

Aliases for FAM227A Gene

  • Family With Sequence Similarity 227 Member A 2 3 5
  • Protein FAM227A 3 3
  • Family With Sequence Similarity 227, Member A 2

External Ids for FAM227A Gene

Previous GeneCards Identifiers for FAM227A Gene

  • GC22M038974

Summaries for FAM227A Gene

GeneCards Summary for FAM227A Gene

FAM227A (Family With Sequence Similarity 227 Member A) is a Protein Coding gene. An important paralog of this gene is FAM227B.

Additional gene information for FAM227A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM227A Gene

Genomics for FAM227A Gene

GeneHancer (GH) Regulatory Elements for FAM227A Gene

Promoters and enhancers for FAM227A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J038655 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.1 -83 2.4 PKNOX1 ARNT ARID4B SIN3A BRCA1 YY1 SLC30A9 ZNF121 POLR2B GLIS2 CBY1 FAM227A TOMM22 ENSG00000228274 DDX17 EIF3L RPL3 SNORD83B SNORD83A PRDX3P1
GH22J038702 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 32.8 -49.1 -49087 6.2 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 GTPBP1 CBY1 DDX17 FAM227A ENSG00000228274 SNORD83B JOSD1 ENSG00000230149 ENSG00000273076 ENSG00000272669
GH22J038691 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 32.8 -40.0 -39991 10.9 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 SSRP1 JOSD1 GC22M043056 CBY1 ENSG00000228274 FAM227A TAB1 ENSG00000230912 PLA2G6 CBX7 CBX6
GH22J038749 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.5 -98.0 -98038 9.7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SUN2 FAM227A CBY1 ENSG00000228274 GTPBP1 DNAL4 MIEF1 JOSD1 APOBEC3G APOBEC3D
GH22J038567 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 34.4 +87.2 87241 4.7 PKNOX1 GLI4 ZNF2 YY1 ZNF213 E2F8 KLF7 ATF7 RUNX3 ZNF263 DMC1 LOC105373031 FAM227A DDX17 SNORD83B RPL3 JOSD1 TAB1 PLA2G6 ENSG00000230149
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM227A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM227A Gene

Genomic Locations for FAM227A Gene
78,510 bases
Minus strand
78,510 bases
Minus strand

Genomic View for FAM227A Gene

Genes around FAM227A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM227A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM227A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM227A Gene

Proteins for FAM227A Gene

  • Protein details for FAM227A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM227A
    Protein Accession:
    Secondary Accessions:
    • B0QY52
    • B7Z7C6
    • Q5TG08

    Protein attributes for FAM227A Gene

    570 amino acids
    Molecular mass:
    66188 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM227A Gene


neXtProt entry for FAM227A Gene

Post-translational modifications for FAM227A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM227A Gene

Domains & Families for FAM227A Gene

Gene Families for FAM227A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM227A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM227 family.
  • Belongs to the FAM227 family.
genes like me logo Genes that share domains with FAM227A: view

No data available for Suggested Antigen Peptide Sequences for FAM227A Gene

Function for FAM227A Gene

Phenotypes From GWAS Catalog for FAM227A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM227A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM227A Gene

Localization for FAM227A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM227A gene
Compartment Confidence
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM227A Gene

Pathways & Interactions for FAM227A Gene

SuperPathways for FAM227A Gene

No Data Available

Interacting Proteins for FAM227A Gene

Gene Ontology (GO) - Biological Process for FAM227A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM227A Gene

Drugs & Compounds for FAM227A Gene

No Compound Related Data Available

Transcripts for FAM227A Gene

mRNA/cDNA for FAM227A Gene

(14) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM227A Gene

Family with sequence similarity 227, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM227A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM227A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP3: - -

Relevant External Links for FAM227A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM227A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM227A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM227A Gene

This gene is overexpressed in Pituitary (x6.0) and Testis (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM227A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM227A Gene:


SOURCE GeneReport for Unigene cluster for FAM227A Gene:

genes like me logo Genes that share expression patterns with FAM227A: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM227A Gene

Orthologs for FAM227A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM227A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM227A 34 33
  • 98.89 (n)
(Bos Taurus)
Mammalia FAM227A 34 33
  • 78.33 (n)
(Rattus norvegicus)
Mammalia Fam227a 33
  • 68.1 (n)
(Mus musculus)
Mammalia Fam227a 16 34 33
  • 68.09 (n)
(Canis familiaris)
Mammalia FAM227A 34
  • 63 (a)
(Monodelphis domestica)
Mammalia FAM227A 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia FAM227A 34
  • 41 (a)
(Anolis carolinensis)
Reptilia FAM227A 34
  • 25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam227a 33
  • 47.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for FAM227A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM227A Gene

Gene Tree for FAM227A (if available)
Gene Tree for FAM227A (if available)
Evolutionary constrained regions (ECRs) for FAM227A: view image

Paralogs for FAM227A Gene

Paralogs for FAM227A Gene

genes like me logo Genes that share paralogs with FAM227A: view

Variants for FAM227A Gene

Sequence variations from dbSNP and Humsavar for FAM227A Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000014531 -- 38,632,237(-) G/A intron_variant
rs1000087048 -- 38,639,456(-) G/A intron_variant
rs1000090830 -- 38,598,887(-) C/T intron_variant
rs1000117809 -- 38,615,761(-) T/A intron_variant
rs1000147590 -- 38,622,465(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM227A Gene

Variant ID Type Subtype PubMed ID
esv1691892 CNV insertion 17803354
esv2678533 CNV deletion 23128226
esv2724231 CNV deletion 23290073
esv28880 CNV gain 19812545
esv3558160 CNV deletion 23714750
esv3647739 CNV gain 21293372
esv3647740 CNV loss 21293372
esv997907 CNV insertion 20482838
nsv3624 CNV deletion 18451855
nsv3625 CNV insertion 18451855
nsv499372 CNV gain 21111241
nsv508733 CNV insertion 20534489
nsv955156 CNV deletion 24416366

Variation tolerance for FAM227A Gene

Gene Damage Index Score: 4.01; 60.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM227A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM227A Gene

Disorders for FAM227A Gene

Additional Disease Information for FAM227A

No disorders were found for FAM227A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM227A Gene

Publications for FAM227A Gene

  1. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for FAM227A Gene

Sources for FAM227A Gene

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