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Aliases for FAM221A Gene

Aliases for FAM221A Gene

  • Family With Sequence Similarity 221 Member A 2 3 5
  • C7orf46 3 4
  • Family With Sequence Similarity 221, Member A 2
  • Chromosome 7 Open Reading Frame 46 2
  • Uncharacterized Protein C7orf46 3
  • Protein FAM221A 3

External Ids for FAM221A Gene

Previous HGNC Symbols for FAM221A Gene

  • C7orf46

Previous GeneCards Identifiers for FAM221A Gene

  • GC07P023720

Summaries for FAM221A Gene

GeneCards Summary for FAM221A Gene

FAM221A (Family With Sequence Similarity 221 Member A) is a Protein Coding gene. An important paralog of this gene is FAM221B.

Additional gene information for FAM221A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM221A Gene

Genomics for FAM221A Gene

GeneHancer (GH) Regulatory Elements for FAM221A Gene

Promoters and enhancers for FAM221A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I023679 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 573.7 +1.0 1026 1.9 NFIB RB1 KLF17 MZF1 SIN3A KLF5 RAD21 YY1 ETS1 ZNF335 FAM221A ENSG00000234286 STK31
GH07I023596 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9 -81.3 -81335 2.7 PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 YY1 ZNF766 E2F8 ZNF143 CCDC126 LOC105375187 FAM221A FCF1P1
GH07I023865 Enhancer 0.9 FANTOM5 ENCODE 16.4 +185.7 185711 0.3 JUN CEBPG RAD21 BRCA1 RFX5 POLR2A RCOR1 NFE2 FOSL2 FOS FAM221A GC07M023895 TPT1P7
GH07I023801 Enhancer 1.2 Ensembl ENCODE 11 +122.7 122722 1 PKNOX1 SMAD1 ARNT FEZF1 ZNF766 E2F8 REST ZNF592 MEF2D SMARCA4 FAM221A STK31 TPT1P7 PCMTD1P3
GH07I023759 Enhancer 1.1 Ensembl ENCODE 8.7 +80.8 80758 1.3 HDAC1 PKNOX1 FEZF1 BRCA1 RFX5 YY1 TCF12 ZNF366 SCRT2 RCOR1 STK31 FAM221A PCMTD1P3 TPT1P7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM221A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM221A Gene

Genomic Locations for FAM221A Gene
23,787 bases
Plus strand

Genomic View for FAM221A Gene

Genes around FAM221A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM221A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM221A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM221A Gene

Proteins for FAM221A Gene

  • Protein details for FAM221A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM221A
    Protein Accession:
    Secondary Accessions:
    • Q05CG4
    • Q4G0Q7
    • Q6P519

    Protein attributes for FAM221A Gene

    298 amino acids
    Molecular mass:
    33083 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH26000.1; Type=Frameshift; Positions=9; Evidence={ECO:0000305}; Sequence=AAH42034.1; Type=Frameshift; Positions=101; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM221A Gene


neXtProt entry for FAM221A Gene

Post-translational modifications for FAM221A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM221A Gene

Domains & Families for FAM221A Gene

Gene Families for FAM221A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM221A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM221 family.
  • Belongs to the FAM221 family.
genes like me logo Genes that share domains with FAM221A: view

No data available for Suggested Antigen Peptide Sequences for FAM221A Gene

Function for FAM221A Gene

Phenotypes for FAM221A Gene

GenomeRNAi human phenotypes for FAM221A:
genes like me logo Genes that share phenotypes with FAM221A: view

miRNA for FAM221A Gene

miRTarBase miRNAs that target FAM221A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM221A Gene

Localization for FAM221A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM221A gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM221A Gene

Pathways & Interactions for FAM221A Gene

SuperPathways for FAM221A Gene

No Data Available

Interacting Proteins for FAM221A Gene

Gene Ontology (GO) - Biological Process for FAM221A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM221A Gene

Drugs & Compounds for FAM221A Gene

No Compound Related Data Available

Transcripts for FAM221A Gene

Unigene Clusters for FAM221A Gene

Family with sequence similarity 221, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM221A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9
SP1: -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -

Relevant External Links for FAM221A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM221A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM221A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM221A Gene

This gene is overexpressed in Testis (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM221A Gene

Protein tissue co-expression partners for FAM221A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM221A Gene:


SOURCE GeneReport for Unigene cluster for FAM221A Gene:

genes like me logo Genes that share expression patterns with FAM221A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM221A Gene

Orthologs for FAM221A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM221A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM221A 33 34
  • 98.99 (n)
(Canis familiaris)
Mammalia FAM221A 33 34
  • 89.26 (n)
(Bos Taurus)
Mammalia FAM221A 33
  • 88.26 (n)
MGC134574 34
  • 85 (a)
(Mus musculus)
Mammalia Fam221a 33 16 34
  • 84 (n)
(Rattus norvegicus)
Mammalia Fam221a 33
  • 83.13 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
-- 34
  • 76 (a)
(Monodelphis domestica)
Mammalia FAM221A 34
  • 74 (a)
(Gallus gallus)
Aves C2H7ORF46 33
  • 73.1 (n)
FAM221A 34
  • 72 (a)
(Anolis carolinensis)
Reptilia FAM221A 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam221a 33
  • 65.06 (n)
Str.617 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10621 33
(Danio rerio)
Actinopterygii fam221a 33 34
  • 59.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
Species where no ortholog for FAM221A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM221A Gene

Gene Tree for FAM221A (if available)
Gene Tree for FAM221A (if available)

Paralogs for FAM221A Gene

Paralogs for FAM221A Gene

(14) SIMAP similar genes for FAM221A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM221A: view

Variants for FAM221A Gene

Sequence variations from dbSNP and Humsavar for FAM221A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000010422 -- 23,682,221(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000023013 -- 23,696,431(+) G/A intron_variant
rs1000080029 -- 23,683,754(+) T/C intron_variant
rs1000117240 -- 23,688,598(+) C/T intron_variant
rs1000354543 -- 23,702,360(+) T/C 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM221A Gene

Variant ID Type Subtype PubMed ID
nsv830924 CNV loss 17160897
nsv7393 OTHER inversion 18451855
esv2759519 CNV loss 17122850
esv2673027 CNV deletion 23128226

Variation tolerance for FAM221A Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM221A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM221A Gene

Disorders for FAM221A Gene

Additional Disease Information for FAM221A

No disorders were found for FAM221A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM221A Gene

Publications for FAM221A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for FAM221A Gene

Sources for FAM221A Gene

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