Aliases for FAM220A Gene

Aliases for FAM220A Gene

  • Family With Sequence Similarity 220 Member A 2 3 5
  • STAT3-Interacting Protein As A Repressor 2 3 4
  • Acrosomal Protein 1 2 3
  • Protein FAM220A 3 4
  • C7orf70 3 4
  • SIPAR 3 4
  • Family With Sequence Similarity 220, Member A 2
  • Chromosome 7 Open Reading Frame 70 2
  • ACPIN1 3

External Ids for FAM220A Gene

Previous HGNC Symbols for FAM220A Gene

  • C7orf70

Previous GeneCards Identifiers for FAM220A Gene

  • GC07M006369

Summaries for FAM220A Gene

GeneCards Summary for FAM220A Gene

FAM220A (Family With Sequence Similarity 220 Member A) is a Protein Coding gene. Diseases associated with FAM220A include Pancreatic Squamous Cell Carcinoma and Hemoglobin C Disease. An important paralog of this gene is ENSG00000286075.

UniProtKB/Swiss-Prot Summary for FAM220A Gene

Additional gene information for FAM220A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM220A Gene

Genomics for FAM220A Gene

GeneHancer (GH) Regulatory Elements for FAM220A Gene

Promoters and enhancers for FAM220A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM220A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM220A

Genomic Locations for FAM220A Gene

Genomic Locations for FAM220A Gene
chr7:6,329,409-6,348,981
(GRCh38/hg38)
Size:
19,573 bases
Orientation:
Minus strand
chr7:6,369,040-6,388,612
(GRCh37/hg19)
Size:
19,573 bases
Orientation:
Minus strand

Genomic View for FAM220A Gene

Genes around FAM220A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM220A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM220A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM220A Gene

Proteins for FAM220A Gene

  • Protein details for FAM220A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4H9-F220A_HUMAN
    Recommended name:
    Protein FAM220A
    Protein Accession:
    Q7Z4H9
    Secondary Accessions:
    • Q75ML2
    • Q8NA52
    • Q9BRR7

    Protein attributes for FAM220A Gene

    Size:
    259 amino acids
    Molecular mass:
    28021 Da
    Quaternary structure:
    • Interacts with STAT3.
    SequenceCaution:
    • Sequence=AAS07509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG34819.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for FAM220A Gene

Post-translational modifications for FAM220A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM220A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM220A Gene

Domains & Families for FAM220A Gene

Gene Families for FAM220A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM220A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM220A Gene

GenScript: Design optimal peptide antigens:
  • STAT3-interacting protein as a repressor (SIPAR_HUMAN)
genes like me logo Genes that share domains with FAM220A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FAM220A Gene

Function for FAM220A Gene

Molecular function for FAM220A Gene

UniProtKB/Swiss-Prot Function:
May negatively regulate STAT3.

Phenotypes From GWAS Catalog for FAM220A Gene

Gene Ontology (GO) - Molecular Function for FAM220A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097677 STAT family protein binding IBA 21873635
genes like me logo Genes that share ontologies with FAM220A: view

Phenotypes for FAM220A Gene

genes like me logo Genes that share phenotypes with FAM220A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM220A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM220A Gene

Localization for FAM220A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM220A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM220A gene
Compartment Confidence
nucleus 4
extracellular 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM220A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with FAM220A: view

Pathways & Interactions for FAM220A Gene

PathCards logo

SuperPathways for FAM220A Gene

No Data Available

Interacting Proteins for FAM220A Gene

;

Gene Ontology (GO) - Biological Process for FAM220A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006470 protein dephosphorylation IBA 21873635
genes like me logo Genes that share ontologies with FAM220A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM220A Gene

Drugs & Compounds for FAM220A Gene

No Compound Related Data Available

Transcripts for FAM220A Gene

mRNA/cDNA for FAM220A Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM220A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM220A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2:
SP3: - -
SP4: - - -

Relevant External Links for FAM220A Gene

GeneLoc Exon Structure for
FAM220A

Expression for FAM220A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM220A Gene

mRNA differential expression in normal tissues according to GTEx for FAM220A Gene

This gene is overexpressed in Testis (x5.6) and Muscle - Skeletal (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM220A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM220A

SOURCE GeneReport for Unigene cluster for FAM220A Gene:

Hs.696146

Evidence on tissue expression from TISSUES for FAM220A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with FAM220A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM220A Gene

Orthologs for FAM220A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM220A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM220A 31 30
  • 98.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM220A 31 30
  • 73.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam220a 30
  • 64.55 (n)
mouse
(Mus musculus)
Mammalia Fam220a 17 31 30
  • 64.33 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM220A 31
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM220A 31
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1877 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.27282 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3854 30
zebrafish
(Danio rerio)
Actinopterygii Dr.14199 30
Species where no ortholog for FAM220A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM220A Gene

ENSEMBL:
Gene Tree for FAM220A (if available)
TreeFam:
Gene Tree for FAM220A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM220A: view image

Paralogs for FAM220A Gene

Paralogs for FAM220A Gene

(2) SIMAP similar genes for FAM220A Gene using alignment to 3 proteins:

  • F220A_HUMAN
  • E9PQC6_HUMAN
  • E9PQY0_HUMAN

Pseudogenes.org Pseudogenes for FAM220A Gene

genes like me logo Genes that share paralogs with FAM220A: view

Variants for FAM220A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM220A Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs2241445 - p.Gly237Ser
rs3750039 - p.Val161Leu
rs3750040 - p.Arg127Gln
rs3750041 - p.Gly71Arg
rs6952125 - p.Val198Met

Additional dbSNP identifiers (rs#s) for FAM220A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM220A Gene

Variant ID Type Subtype PubMed ID
esv1914954 OTHER inversion 16254605
esv2668165 CNV deletion 23128226
esv3541120 CNV deletion 23714750
esv3612023 CNV loss 21293372
nsv1020236 CNV gain 25217958
nsv1020251 CNV loss 25217958
nsv1025381 CNV loss 25217958
nsv436904 CNV insertion 17901297
nsv7392 OTHER inversion 18451855
nsv970442 CNV duplication 23825009

Variation tolerance for FAM220A Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.24; 85.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM220A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM220A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM220A Gene

Disorders for FAM220A Gene

MalaCards: The human disease database

(3) MalaCards diseases for FAM220A Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM220A

genes like me logo Genes that share disorders with FAM220A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM220A Gene

Publications for FAM220A Gene

  1. Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. (PMID: 26026268) Ren F … Chang Z (FEBS letters 2015) 2 3 54
  2. SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma. (PMID: 23917203) Ren F … Chang Z (Cellular signalling 2013) 2 3 54
  3. Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein. (PMID: 19659802) Ueda T … Tanaka H (International journal of urology : official journal of the Japanese Urological Association 2009) 2 3 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 54

Products for FAM220A Gene

Sources for FAM220A Gene