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Aliases for FAM219B Gene

Aliases for FAM219B Gene

  • Family With Sequence Similarity 219 Member B 2 3 5
  • C15orf17 3 4
  • Family With Sequence Similarity 219, Member B 2
  • Chromosome 15 Open Reading Frame 17 2
  • Uncharacterized Protein C15orf17 3
  • Protein FAM219B 3

External Ids for FAM219B Gene

Previous HGNC Symbols for FAM219B Gene

  • C15orf17

Previous GeneCards Identifiers for FAM219B Gene

  • GC15M075193

Summaries for FAM219B Gene

GeneCards Summary for FAM219B Gene

FAM219B (Family With Sequence Similarity 219 Member B) is a Protein Coding gene. An important paralog of this gene is FAM219A.

Additional gene information for FAM219B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM219B Gene

Genomics for FAM219B Gene

GeneHancer (GH) Regulatory Elements for FAM219B Gene

Promoters and enhancers for FAM219B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074904 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.9 916 2.9 HDGF PKNOX1 SMAD1 SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 ZNF207 FAM219B RPP25 DNM1P35 ULK3 ODF3L1 GC15P074895
GH15I073919 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.7 +981.4 981401 12.4 PKNOX1 ARNT SIN3A ZNF2 ZNF143 FOS REST ZNF662 ZFP41 ZNF610 LOXL1 EDC3 LOXL1-AS1 FAM219B CD276 LOC102723657 ISLR STOML1 PIR34107 GC15M073919
GH15I074613 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.9 +291.0 290993 4.9 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 CLK3 ENSG00000260919 LOC102723750 SIN3A EDC3 MAN2C1 ENSG00000260274 PML UBL7-AS1 FAM219B
GH15I075366 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.8 -461.4 -461448 3.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000260274 MAN2C1 DNM1P35 SIN3A LOC441728 FBXO22 EDC3 COMMD4 LOC101929333 CLK3
GH15I074775 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +119.1 119134 26 DMAP1 IRF4 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D GLIS1 RCOR2 CSK MIR4513 EDC3 SIN3A LOC441728 ULK3 ENSG00000260274 C15orf39 DNM1P35 ENSG00000203392
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM219B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM219B Gene

Genomic Locations for FAM219B Gene
7,321 bases
Minus strand

Genomic View for FAM219B Gene

Genes around FAM219B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM219B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM219B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM219B Gene

Proteins for FAM219B Gene

  • Protein details for FAM219B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM219B
    Protein Accession:
    Secondary Accessions:
    • A8K4Q5
    • B4DK57
    • Q9NXY0

    Protein attributes for FAM219B Gene

    198 amino acids
    Molecular mass:
    21103 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM219B Gene


neXtProt entry for FAM219B Gene

Post-translational modifications for FAM219B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM219B Gene

Domains & Families for FAM219B Gene

Gene Families for FAM219B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM219B Gene


Suggested Antigen Peptide Sequences for FAM219B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM219 family.
  • Belongs to the FAM219 family.
genes like me logo Genes that share domains with FAM219B: view

Function for FAM219B Gene

Phenotypes From GWAS Catalog for FAM219B Gene

genes like me logo Genes that share phenotypes with FAM219B: view

Animal Model Products

miRNA for FAM219B Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM219B Gene

Localization for FAM219B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM219B gene
Compartment Confidence
nucleus 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM219B Gene

Pathways & Interactions for FAM219B Gene

SuperPathways for FAM219B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM219B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM219B Gene

Drugs & Compounds for FAM219B Gene

No Compound Related Data Available

Transcripts for FAM219B Gene

Unigene Clusters for FAM219B Gene

Family with sequence similarity 219, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM219B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i · 7j · 7k · 7l ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - - - - - - - - -
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: -
SP13: - - -
SP14: - -
SP15: -
SP16: - - - - - -

ExUns: 8a · 8b · 8c ^ 9
SP1: - -

Relevant External Links for FAM219B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM219B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM219B Gene

Protein differential expression in normal tissues from HIPED for FAM219B Gene

This gene is overexpressed in Liver (55.9), Monocytes (6.5), and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM219B Gene

Protein tissue co-expression partners for FAM219B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM219B Gene:


SOURCE GeneReport for Unigene cluster for FAM219B Gene:


Evidence on tissue expression from TISSUES for FAM219B Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with FAM219B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM219B Gene

Orthologs for FAM219B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM219B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM219B 33 34
  • 92.15 (n)
(Canis familiaris)
Mammalia C30H15orf17 33
  • 89.95 (n)
FAM219B 34
  • 32 (a)
(Bos Taurus)
Mammalia C21H15orf17 33
  • 88.31 (n)
FAM219B 34
  • 87 (a)
(Mus musculus)
Mammalia Fam219b 33 16 34
  • 86.13 (n)
(Rattus norvegicus)
Mammalia Fam219b 33
  • 81.63 (n)
(Monodelphis domestica)
Mammalia FAM219B 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia FAM219B 34
  • 65 (a)
(Gallus gallus)
Aves FAM219B 33
  • 77.13 (n)
(Anolis carolinensis)
Reptilia FAM219B 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam219b 33
  • 66.9 (n)
Str.3563 33
(Danio rerio)
Actinopterygii fam219b 33 34
  • 60.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.170 34
  • 42 (a)
Species where no ortholog for FAM219B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM219B Gene

Gene Tree for FAM219B (if available)
Gene Tree for FAM219B (if available)

Paralogs for FAM219B Gene

Paralogs for FAM219B Gene

(2) SIMAP similar genes for FAM219B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FAM219B: view

Variants for FAM219B Gene

Sequence variations from dbSNP and Humsavar for FAM219B Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000271905 -- 74,902,663(-) AGCAGGAGCA/AGCA coding_sequence_variant, inframe_deletion, non_coding_transcript_variant
rs1000281225 -- 74,904,146(-) G/A intron_variant
rs1000302948 -- 74,903,128(-) TGA/ intron_variant
rs1000432880 -- 74,908,501(-) G/A upstream_transcript_variant
rs1001715109 -- 74,901,620(-) G/A 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM219B Gene

Variant ID Type Subtype PubMed ID
nsv1121512 CNV deletion 24896259
nsv819808 CNV gain 19587683

Variation tolerance for FAM219B Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM219B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM219B Gene

Disorders for FAM219B Gene

Additional Disease Information for FAM219B

No disorders were found for FAM219B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM219B Gene

Publications for FAM219B Gene

  1. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for FAM219B Gene

Sources for FAM219B Gene

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