Aliases for FAM218A Gene

Subcategory (RNA class) for FAM218A Gene

lncRNA

Aliases for FAM218A Gene

  • Family With Sequence Similarity 218 Member A 2 3 5
  • TRIM61 Antisense RNA 1 2 3
  • Protein FAM218A 3 4
  • TRIM61-AS1 2 3
  • C4orf39 3 4
  • FAM218A 2 5
  • Family With Sequence Similarity 218, Member A 2
  • Chromosome 4 Open Reading Frame 39 2
  • Uncharacterized Protein C4orf39 3
  • FLJ31659 2

External Ids for FAM218A Gene

Previous HGNC Symbols for FAM218A Gene

  • C4orf39

Previous GeneCards Identifiers for FAM218A Gene

  • GC04P165879

Summaries for FAM218A Gene

GeneCards Summary for FAM218A Gene

FAM218A (Family With Sequence Similarity 218 Member A) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for FAM218A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM218A Gene

Genomics for FAM218A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM218A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J164956 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 600.7 +1.5 1547 4.2 SP1 ZNF629 POLR2A LARP7 GABPA ZNF143 SMAD5 NR2C1 ZNF501 GTF2F1 FAM218A TRIM60P14 ENSG00000250712 piR-35674-401 lnc-FAM218A-3 TRIM61 APELA
GH04J164760 Enhancer 0.5 ENCODE 14.8 -195.8 -195777 2.2 ZBTB11 ZC3H11A ZFP64 ZNF781 ZNF518A ZNF697 PRDM12 SMIM31 FAM218A RNU6-668P lnc-APELA-2 RF00026-836 APELA
GH04J165439 Enhancer 1.2 FANTOM5 Ensembl ENCODE 2.8 +483.3 483253 2.8 CREB1 PRDM10 ZNF629 ZNF692 ZIC2 ZSCAN4 PATZ1 ZNF341 ATF7 ZNF561 CPE MIR578 HADHAP1 FAM218A RF00017-4449 TLL1
GH04J164961 Enhancer 0.4 FANTOM5 Ensembl 7.3 +4.1 4089 0.9 piR-35674-401 TRIM60P14 FAM218A CPE lnc-TMEM192-4 lnc-FAM218A-3 TRIM61 APELA
GH04J165410 Enhancer 0.2 FANTOM5 1.4 +453.4 453397 0.2 MSMO1 CPE FAM218A HADHAP1 RF00017-4449 TLL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM218A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM218A

Genomic Locations for FAM218A Gene

Genomic Locations for FAM218A Gene
chr4:164,956,948-164,959,131
(GRCh38/hg38)
Size:
2,184 bases
Orientation:
Plus strand
chr4:165,878,100-165,880,273
(GRCh37/hg19)
Size:
2,174 bases
Orientation:
Plus strand

Genomic View for FAM218A Gene

Genes around FAM218A on UCSC Golden Path with GeneCards custom track
FAM218A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
FAM218A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM218A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM218A Gene

Proteins for FAM218A Gene

  • Protein details for FAM218A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MZ4-F218A_HUMAN
    Recommended name:
    Protein FAM218A
    Protein Accession:
    Q96MZ4

    Protein attributes for FAM218A Gene

    Size:
    157 amino acids
    Molecular mass:
    17021 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM218A Gene

Post-translational modifications for FAM218A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM218A Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for FAM218A Gene

Domains & Families for FAM218A Gene

Gene Families for FAM218A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM218A Gene

ProtoNet:
genes like me logo Genes that share domains with FAM218A: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FAM218A Gene

Function for FAM218A Gene

Phenotypes From GWAS Catalog for FAM218A Gene

Gene Ontology (GO) - Molecular Function for FAM218A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM218A: view

Phenotypes for FAM218A Gene

genes like me logo Genes that share phenotypes with FAM218A: view

Animal Model Products

CRISPR Products

miRNA for FAM218A Gene

miRTarBase miRNAs that target FAM218A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM218A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM218A Gene

Localization for FAM218A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM218A gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM218A Gene

Pathways & Interactions for FAM218A Gene

PathCards logo

SuperPathways for FAM218A Gene

No Data Available

Interacting Proteins for FAM218A Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q96MZ4-F218A_HUMAN ENSP00000427428 for FAM218A Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for FAM218A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM218A Gene

Drugs & Compounds for FAM218A Gene

No Compound Related Data Available

Transcripts for FAM218A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for FAM218A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000E60AFE_9606 lncRNA 2184 2

HGNC: 26466,

RefSeq: NR_160935,

URS0000DB72B4_9606 lncRNA 2175 1

Ensembl: ENST00000648094 (view in UCSC) ,

FAM218A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for FAM218A Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM218A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM218A Gene

No ASD Table

Relevant External Links for FAM218A Gene

GeneLoc Exon Structure for
FAM218A

Expression for FAM218A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM218A Gene

Protein differential expression in normal tissues from HIPED for FAM218A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM218A Gene



Protein tissue co-expression partners for FAM218A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM218A

SOURCE GeneReport for Unigene cluster for FAM218A Gene:

Hs.178648
genes like me logo Genes that share expression patterns with FAM218A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM218A Gene

Orthologs for FAM218A Gene

Evolution for FAM218A Gene

ENSEMBL:
Gene Tree for FAM218A (if available)
TreeFam:
Gene Tree for FAM218A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM218A: view image

No data available for Orthologs for FAM218A Gene

Paralogs for FAM218A Gene

Pseudogenes.org Pseudogenes for FAM218A Gene

genes like me logo Genes that share paralogs with FAM218A: view

No data available for Paralogs for FAM218A Gene

Variants for FAM218A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM218A Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs3733418 - p.His54Arg

Additional dbSNP identifiers (rs#s) for FAM218A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM218A Gene

Variant ID Type Subtype PubMed ID
esv21636 CNV gain 19812545
esv2421831 CNV duplication 20811451
esv2759299 CNV gain 17122850
esv2760876 CNV gain 21179565
esv3603011 CNV gain 21293372
nsv1019150 CNV gain 25217958
nsv10607 CNV gain 18304495
nsv517554 CNV loss 19592680
nsv528686 CNV gain 19592680
nsv830140 CNV loss 17160897

Variation tolerance for FAM218A Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM218A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM218A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM218A Gene

Disorders for FAM218A Gene

No disorders were found for FAM218A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM218A Gene

Publications for FAM218A Gene

  1. Loose ends: almost one in five human genes still have unresolved coding status. (PMID: 29982784) Abascal F … Tress ML (Nucleic acids research 2018) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3

Products for FAM218A Gene

Sources for FAM218A Gene