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Aliases for FAM217B Gene

Aliases for FAM217B Gene

  • Family With Sequence Similarity 217 Member B 2 3 5
  • C20orf177 3 4
  • Family With Sequence Similarity 217, Member B 2
  • Chromosome 20 Open Reading Frame 177 2
  • Uncharacterized Protein C20orf177 3
  • Protein FAM217B 3
  • DJ551D2.5 3

External Ids for FAM217B Gene

Previous HGNC Symbols for FAM217B Gene

  • C20orf177

Previous GeneCards Identifiers for FAM217B Gene

  • GC20P058509

Summaries for FAM217B Gene

GeneCards Summary for FAM217B Gene

FAM217B (Family With Sequence Similarity 217 Member B) is a Protein Coding gene.

Additional gene information for FAM217B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM217B Gene

Genomics for FAM217B Gene

GeneHancer (GH) Regulatory Elements for FAM217B Gene

Promoters and enhancers for FAM217B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I059938 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.4 +6.5 6546 4 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B NEUROD1 SIN3A YBX1 DMAP1 PPP1R3D FAM217B NELFCD CDH26
GH20I059933 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 314 1.4 HDGF ARID4B SIN3A ZBTB7B ZNF48 GLIS2 ELK1 ZNF207 ZNF143 FOS FAM217B SYCP2 NELFCD PPP1R3D
GH20I059931 Promoter/Enhancer 1.1 EPDnew ENCODE 550.8 -1.9 -1941 1.4 ZNF687 ZBTB11 ZNF10 ZSCAN4 FEZF1 ZKSCAN1 NONO PRDM6 GATA3 GLIS1 FAM217B SYCP2 RNU7-141P
GH20I060054 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +123.2 123184 4.9 YBX1 FEZF1 GLIS2 ELK1 ZNF143 REST ZNF518A ZNF592 GLIS1 WT1 C20orf197 PPP1R3D FAM217B SYCP2 ENSG00000276093
GH20I060045 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 2 +112.8 112797 1.5 OSR2 POLR2A GLIS1 MAX CREB1 OVOL3 REST MYC SPI1 C20orf197 PPP1R3D FAM217B PHACTR3 CDH26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM217B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM217B Gene

Genomic Locations for FAM217B Gene
chr20:59,933,764-59,948,680
(GRCh38/hg38)
Size:
14,917 bases
Orientation:
Plus strand
chr20:58,508,819-58,523,735
(GRCh37/hg19)

Genomic View for FAM217B Gene

Genes around FAM217B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM217B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM217B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM217B Gene

Proteins for FAM217B Gene

  • Protein details for FAM217B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTX9-F217B_HUMAN
    Recommended name:
    Protein FAM217B
    Protein Accession:
    Q9NTX9
    Secondary Accessions:
    • B3KWH1
    • Q9NTA3

    Protein attributes for FAM217B Gene

    Size:
    383 amino acids
    Molecular mass:
    42052 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM217B Gene

Post-translational modifications for FAM217B Gene

No Post-translational modifications

Other Protein References for FAM217B Gene

No data available for DME Specific Peptides for FAM217B Gene

Domains & Families for FAM217B Gene

Gene Families for FAM217B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM217B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM217B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NTX9

UniProtKB/Swiss-Prot:

F217B_HUMAN :
  • Belongs to the FAM217 family.
Family:
  • Belongs to the FAM217 family.
genes like me logo Genes that share domains with FAM217B: view

Function for FAM217B Gene

genes like me logo Genes that share phenotypes with FAM217B: view

Animal Models for FAM217B Gene

MGI Knock Outs for FAM217B:

miRNA for FAM217B Gene

miRTarBase miRNAs that target FAM217B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM217B Gene

Localization for FAM217B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM217B gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM217B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with FAM217B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM217B Gene

Pathways & Interactions for FAM217B Gene

SuperPathways for FAM217B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM217B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM217B Gene

Drugs & Compounds for FAM217B Gene

No Compound Related Data Available

Transcripts for FAM217B Gene

Unigene Clusters for FAM217B Gene

Family with sequence similarity 217, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM217B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for FAM217B Gene

GeneLoc Exon Structure for
FAM217B
ECgene alternative splicing isoforms for
FAM217B

Expression for FAM217B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM217B Gene

mRNA differential expression in normal tissues according to GTEx for FAM217B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of FAM217B Gene:

FAM217B

SOURCE GeneReport for Unigene cluster for FAM217B Gene:

Hs.54973

Evidence on tissue expression from TISSUES for FAM217B Gene

  • Nervous system(4.3)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with FAM217B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM217B Gene

Orthologs for FAM217B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM217B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM217B 33 34
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia FAM217B 33 34
  • 74.6 (n)
mouse
(Mus musculus)
Mammalia Fam217b 33 16 34
  • 71.43 (n)
rat
(Rattus norvegicus)
Mammalia Fam217b 33
  • 69.83 (n)
dog
(Canis familiaris)
Mammalia C24H20orf177 33
  • 63.59 (n)
FAM217B 34
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM217B 34
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM217B 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves C20H20ORF177 33
  • 59.89 (n)
FAM217B 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM217B 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam217b 34
  • 17 (a)
OneToMany
FAM217B (2 of 2) 34
  • 17 (a)
OneToMany
Species where no ortholog for FAM217B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM217B Gene

ENSEMBL:
Gene Tree for FAM217B (if available)
TreeFam:
Gene Tree for FAM217B (if available)

Paralogs for FAM217B Gene

(1) SIMAP similar genes for FAM217B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM217B: view

No data available for Paralogs for FAM217B Gene

Variants for FAM217B Gene

Sequence variations from dbSNP and Humsavar for FAM217B Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
VAR_035691 A breast cancer sample p.Ser95Gly
rs1000034704 -- 59,936,647(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000085208 -- 59,936,479(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000248144 -- 59,933,179(+) G/A upstream_transcript_variant
rs1000296092 -- 59,933,296(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM217B Gene

Variant ID Type Subtype PubMed ID
nsv1065994 CNV loss 25217958
nsv1062669 CNV loss 25217958
dgv4336n100 CNV loss 25217958
dgv4335n100 CNV loss 25217958

Variation tolerance for FAM217B Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM217B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM217B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM217B Gene

Disorders for FAM217B Gene

Additional Disease Information for FAM217B

No disorders were found for FAM217B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM217B Gene

Publications for FAM217B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for FAM217B Gene

Sources for FAM217B Gene

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