Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM217A Gene

Aliases for FAM217A Gene

  • Family With Sequence Similarity 217 Member A 2 3 5
  • C6orf146 3 4
  • Family With Sequence Similarity 217, Member A 2
  • Chromosome 6 Open Reading Frame 146 2
  • Uncharacterized Protein C6orf146 3
  • Protein FAM217A 3

External Ids for FAM217A Gene

Previous HGNC Symbols for FAM217A Gene

  • C6orf146

Summaries for FAM217A Gene

GeneCards Summary for FAM217A Gene

FAM217A (Family With Sequence Similarity 217 Member A) is a Protein Coding gene.

Additional gene information for FAM217A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM217A Gene

Genomics for FAM217A Gene

GeneHancer (GH) Regulatory Elements for FAM217A Gene

Promoters and enhancers for FAM217A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I004088 Enhancer 0.3 ENCODE 550.8 -1.7 -1701 1.1 GLIS1 FAM217A GC06M004088 LOC100507506 ENSG00000254821 ECI2 C6orf201 GC06P004125
GH06I004133 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 -47.9 -47886 3.8 HDGF SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ECI2 ENSG00000254821 LOC100507506 C6orf201 FAM217A GC06P004132
GH06I003612 Enhancer 1 ENCODE 12.1 +474.6 474601 1.5 HDGF PKNOX1 FEZF1 ZNF2 ZNF213 KLF7 FOS KLF13 YY2 REST PSMG4 PRPF4B C6orf201 FAM217A WRNIP1 GC06P003631 GC06M003534 LOC100507336
GH06I004057 Enhancer 0.9 Ensembl ENCODE 11.5 +28.1 28118 2.9 ELF3 SAP130 JUN ARID4B MAX RAD21 RARA FOSL1 POLR2A FOSL2 ENSG00000230648 ECI2 ENSG00000254821 LOC100507506 PRPF4B FAM217A ENSG00000272248 GC06M004066 GC06M004041
GH06I004188 Enhancer 0.4 FANTOM5 24.4 -101.6 -101641 0.1 NRF1 ZBTB33 GC06P004191 LOC102724096 LOC100129052 PIR45418 C6orf201 FAM217A LOC100507506
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM217A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM217A Gene

Genomic Locations for FAM217A Gene
chr6:4,049,434-4,087,344
(GRCh38/hg38)
Size:
37,911 bases
Orientation:
Minus strand
chr6:4,049,668-4,087,578
(GRCh37/hg19)

Genomic View for FAM217A Gene

Genes around FAM217A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM217A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM217A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM217A Gene

Proteins for FAM217A Gene

  • Protein details for FAM217A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXS0-F217A_HUMAN
    Recommended name:
    Protein FAM217A
    Protein Accession:
    Q8IXS0
    Secondary Accessions:
    • Q5JYK1

    Protein attributes for FAM217A Gene

    Size:
    508 amino acids
    Molecular mass:
    57420 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI42122.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FAM217A Gene

Post-translational modifications for FAM217A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM217A Gene

Domains & Families for FAM217A Gene

Gene Families for FAM217A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM217A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IXS0

UniProtKB/Swiss-Prot:

F217A_HUMAN :
  • Belongs to the FAM217 family.
Family:
  • Belongs to the FAM217 family.
genes like me logo Genes that share domains with FAM217A: view

No data available for Suggested Antigen Peptide Sequences for FAM217A Gene

Function for FAM217A Gene

Phenotypes From GWAS Catalog for FAM217A Gene

Phenotypes for FAM217A Gene

GenomeRNAi human phenotypes for FAM217A:
genes like me logo Genes that share phenotypes with FAM217A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM217A Gene

Localization for FAM217A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM217A gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM217A Gene

Pathways & Interactions for FAM217A Gene

SuperPathways for FAM217A Gene

No Data Available

Interacting Proteins for FAM217A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000274673%0d%0a9606.ENSP00000226951%0d%0a
Selected Interacting proteins: Q8IXS0-F217A_HUMAN ENSP00000274673 for FAM217A Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM217A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM217A Gene

Drugs & Compounds for FAM217A Gene

No Compound Related Data Available

Transcripts for FAM217A Gene

Unigene Clusters for FAM217A Gene

Family with sequence similarity 217, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM217A Gene

No ASD Table

Relevant External Links for FAM217A Gene

GeneLoc Exon Structure for
FAM217A
ECgene alternative splicing isoforms for
FAM217A

Expression for FAM217A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM217A Gene

mRNA differential expression in normal tissues according to GTEx for FAM217A Gene

This gene is overexpressed in Testis (x41.7).

Protein differential expression in normal tissues from HIPED for FAM217A Gene

This gene is overexpressed in Pancreatic juice (43.1) and Plasma (25.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM217A Gene



Protein tissue co-expression partners for FAM217A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM217A Gene:

FAM217A

SOURCE GeneReport for Unigene cluster for FAM217A Gene:

Hs.657342
genes like me logo Genes that share expression patterns with FAM217A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM217A Gene

Orthologs for FAM217A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM217A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM217A 33
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia C35H6orf146 33
  • 85.19 (n)
FAM217A 34
  • 56 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM217A 33 34
  • 76.45 (n)
mouse
(Mus musculus)
Mammalia Fam217a 33 16 34
  • 75.23 (n)
rat
(Rattus norvegicus)
Mammalia Fam217a 33
  • 74.52 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM217A 34
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM217A 34
  • 38 (a)
OneToOne
Species where no ortholog for FAM217A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM217A Gene

ENSEMBL:
Gene Tree for FAM217A (if available)
TreeFam:
Gene Tree for FAM217A (if available)

Paralogs for FAM217A Gene

Pseudogenes.org Pseudogenes for FAM217A Gene

genes like me logo Genes that share paralogs with FAM217A: view

No data available for Paralogs for FAM217A Gene

Variants for FAM217A Gene

Sequence variations from dbSNP and Humsavar for FAM217A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000085707 -- 4,078,013(-) T/C 5_prime_UTR_variant, intron_variant
rs1000210612 -- 4,071,773(-) T/C intron_variant
rs1000329092 -- 4,075,218(-) C/T intron_variant
rs1000428451 -- 4,084,728(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000663698 -- 4,073,696(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM217A Gene

Variant ID Type Subtype PubMed ID
nsv600860 CNV loss 21841781

Variation tolerance for FAM217A Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.04; 84.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM217A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM217A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM217A Gene

Disorders for FAM217A Gene

Additional Disease Information for FAM217A

No disorders were found for FAM217A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM217A Gene

Publications for FAM217A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for FAM217A Gene

Sources for FAM217A Gene

Content
Loading form....