Aliases for FAM216B Gene

Aliases for FAM216B Gene

  • Family With Sequence Similarity 216 Member B 2 3 5
  • Protein FAM216B 3 4
  • C13orf30 3 4
  • Family With Sequence Similarity 216, Member B 2
  • Chromosome 13 Open Reading Frame 30 2

External Ids for FAM216B Gene

Previous HGNC Symbols for FAM216B Gene

  • C13orf30

Previous GeneCards Identifiers for FAM216B Gene

  • GC13P043356

Summaries for FAM216B Gene

GeneCards Summary for FAM216B Gene

FAM216B (Family With Sequence Similarity 216 Member B) is a Protein Coding gene. An important paralog of this gene is FAM216A.

Additional gene information for FAM216B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM216B Gene

Genomics for FAM216B Gene

GeneHancer (GH) Regulatory Elements for FAM216B Gene

Promoters and enhancers for FAM216B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J042780 Enhancer 0.3 Ensembl 500.7 -1.1 -1051 1.4 POLR2A SMARCA4 FAM216B LINC01050 piR-39858-150
GH13J042781 Promoter 0.3 EPDnew 500.7 +0.0 15 0.1 FAM216B lnc-FAM216B-1 LINC01050
GH13J042832 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +51.2 51151 1.4 FOS REST POLR2A CTBP1 FOXA2 ZBTB33 JUND EZH2 RXRA MAX FAM216B LINC01050 EPSTI1 lnc-FAM216B-1 piR-56229-021
GH13J042814 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 +33.6 33551 1.8 ZSCAN5C JUND FOS ZNF10 EP300 ZEB1 OSR2 GATA3 CEBPB JUN FAM216B LINC01050 lnc-FAM216B-1
GH13J042836 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +55.6 55617 2.1 CTCF RAD21 FOXA2 SMC3 JUND HNF4A YY1 POLR2A PKNOX1 FOXA1 FAM216B LINC01050 lnc-FAM216B-1 piR-56229-021
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM216B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM216B

Genomic Locations for FAM216B Gene

Genomic Locations for FAM216B Gene
chr13:42,781,550-42,791,549
(GRCh38/hg38)
Size:
10,000 bases
Orientation:
Plus strand
chr13:43,355,686-43,365,685
(GRCh37/hg19)
Size:
10,000 bases
Orientation:
Plus strand

Genomic View for FAM216B Gene

Genes around FAM216B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM216B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM216B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM216B Gene

Proteins for FAM216B Gene

  • Protein details for FAM216B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7L0-F216B_HUMAN
    Recommended name:
    Protein FAM216B
    Protein Accession:
    Q8N7L0
    Secondary Accessions:
    • B1ALI3

    Protein attributes for FAM216B Gene

    Size:
    139 amino acids
    Molecular mass:
    16362 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM216B Gene

Post-translational modifications for FAM216B Gene

No Post-translational modifications

Other Protein References for FAM216B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM216B Gene

Domains & Families for FAM216B Gene

Gene Families for FAM216B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM216B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N7L0

UniProtKB/Swiss-Prot:

F216B_HUMAN :
  • Belongs to the FAM216 family.
Family:
  • Belongs to the FAM216 family.
genes like me logo Genes that share domains with FAM216B: view

No data available for Suggested Antigen Peptide Sequences for FAM216B Gene

Function for FAM216B Gene

Phenotypes From GWAS Catalog for FAM216B Gene

genes like me logo Genes that share phenotypes with FAM216B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM216B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM216B Gene

Localization for FAM216B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM216B gene
Compartment Confidence
mitochondrion 3
peroxisome 0
nucleus 0
cytosol 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM216B Gene

Pathways & Interactions for FAM216B Gene

PathCards logo

SuperPathways for FAM216B Gene

No Data Available

Interacting Proteins for FAM216B Gene

;

Gene Ontology (GO) - Biological Process for FAM216B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM216B Gene

Drugs & Compounds for FAM216B Gene

No Compound Related Data Available

Transcripts for FAM216B Gene

mRNA/cDNA for FAM216B Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM216B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM216B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for FAM216B Gene

GeneLoc Exon Structure for
FAM216B

Expression for FAM216B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM216B Gene

mRNA differential expression in normal tissues according to GTEx for FAM216B Gene

This gene is overexpressed in Heart - Atrial Appendage (x15.8), Cervix - Endocervix (x6.2), Fallopian Tube (x5.6), Brain - Hypothalamus (x5.0), Brain - Caudate (basal ganglia) (x4.7), and Lung (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM216B

SOURCE GeneReport for Unigene cluster for FAM216B Gene:

Hs.16970
genes like me logo Genes that share expression patterns with FAM216B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM216B Gene

Orthologs for FAM216B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM216B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM216B 31 30
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM216B 31 30
  • 82.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM216B 31 30
  • 80.34 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam216b 30
  • 74.1 (n)
mouse
(Mus musculus)
Mammalia Fam216b 17 31 30
  • 73.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM216B 31
  • 21 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM216B 31
  • 38 (a)
OneToOne
Species where no ortholog for FAM216B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM216B Gene

ENSEMBL:
Gene Tree for FAM216B (if available)
TreeFam:
Gene Tree for FAM216B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM216B: view image

Paralogs for FAM216B Gene

Paralogs for FAM216B Gene

genes like me logo Genes that share paralogs with FAM216B: view

Variants for FAM216B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM216B Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs35889214 - p.Arg134Cys

Additional dbSNP identifiers (rs#s) for FAM216B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM216B Gene

Variant ID Type Subtype PubMed ID
dgv3129n54 CNV gain 21841781
esv3892334 CNV gain 25118596
nsv455869 CNV gain 19166990
nsv561552 CNV gain 21841781
nsv561555 CNV gain 21841781

Variation tolerance for FAM216B Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM216B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM216B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM216B Gene

Disorders for FAM216B Gene

Additional Disease Information for FAM216B

No disorders were found for FAM216B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM216B Gene

Publications for FAM216B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 4 54

Products for FAM216B Gene

Sources for FAM216B Gene