Aliases for FAM214A Gene

Aliases for FAM214A Gene

  • Family With Sequence Similarity 214 Member A 2 3 5
  • KIAA1370 2 3 4
  • Protein FAM214A 3 4
  • Family With Sequence Similarity 214, Member A 2

External Ids for FAM214A Gene

Previous HGNC Symbols for FAM214A Gene

  • KIAA1370

Previous GeneCards Identifiers for FAM214A Gene

  • GC15M052874
  • GC15M052876
  • GC15M053028
  • GC15M053500
  • GC15M054147

Summaries for FAM214A Gene

GeneCards Summary for FAM214A Gene

FAM214A (Family With Sequence Similarity 214 Member A) is a Protein Coding gene. An important paralog of this gene is FAM214B.

Additional gene information for FAM214A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM214A Gene

Genomics for FAM214A Gene

GeneHancer (GH) Regulatory Elements for FAM214A Gene

Promoters and enhancers for FAM214A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J052676 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 506.9 +29.3 29309 8.1 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 SIN3A POLR2G USF1 PHF8 ZFX FAM214A ENSG00000287500 LOC105370821 lnc-ONECUT1-5 TMOD2 ARPP19 MYO5A GNB5 ENSG00000259935 lnc-MAPK6-17
GH15J052708 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 500.7 +0.2 184 2 FOXK2 ZNF10 ZNF623 HDAC2 RBM25 FOXA2 OSR2 KMT2B TCF12 WT1 FAM214A piR-61101-221
GH15J052668 Promoter 0.3 EPDnew 500.3 +41.0 41014 0.1 FAM214A lnc-ONECUT1-5 ENSG00000259935
GH15J052565 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11 +142.3 142269 4.9 EP300 HNRNPK ZBTB40 ZNF217 SIN3A POLR2G PHF8 JUND SIX5 CTCF ARPP19 ENSG00000260618 ENSG00000259712 ENSG00000259935 FAM214A lnc-MYO5A-1
GH15J052651 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 +57.0 56990 3.7 ZNF217 EP300 TCF12 JUND RFX1 NFYB MXI1 ZNF341 RBM25 ZSCAN9 FAM214A GNB5 MIR1266 ENSG00000259935 lnc-ONECUT1-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM214A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM214A

Genomic Locations for FAM214A Gene

Genomic Locations for FAM214A Gene
128,501 bases
Minus strand
128,501 bases
Minus strand

Genomic View for FAM214A Gene

Genes around FAM214A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM214A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM214A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM214A Gene

Proteins for FAM214A Gene

  • Protein details for FAM214A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM214A
    Protein Accession:
    Secondary Accessions:
    • A8KA52
    • B4DEP5
    • B4DF40
    • F5H8G0
    • Q32MH6
    • Q4G0R7
    • Q5XJ16
    • Q6PDA3
    • Q9NV24
    • Q9P2H7

    Protein attributes for FAM214A Gene

    1076 amino acids
    Molecular mass:
    121670 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91936.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA92608.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAG57156.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM214A Gene


neXtProt entry for FAM214A Gene

Post-translational modifications for FAM214A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM214A Gene

Domains & Families for FAM214A Gene

Gene Families for FAM214A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM214A Gene


Suggested Antigen Peptide Sequences for FAM214A Gene

GenScript: Design optimal peptide antigens:
  • KIAA1370 protein (Q6DKH7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM214 family.
  • Belongs to the FAM214 family.
genes like me logo Genes that share domains with FAM214A: view

Function for FAM214A Gene

Phenotypes From GWAS Catalog for FAM214A Gene

Gene Ontology (GO) - Molecular Function for FAM214A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM214A: view
genes like me logo Genes that share phenotypes with FAM214A: view

Animal Model Products

CRISPR Products

miRNA for FAM214A Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM214A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM214A Gene

Localization for FAM214A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM214A gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM214A Gene

Pathways & Interactions for FAM214A Gene

PathCards logo

SuperPathways for FAM214A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM214A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM214A Gene

Drugs & Compounds for FAM214A Gene

No Compound Related Data Available

Transcripts for FAM214A Gene

mRNA/cDNA for FAM214A Gene

17 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM214A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM214A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP8: -

Relevant External Links for FAM214A Gene

GeneLoc Exon Structure for

Expression for FAM214A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM214A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM214A Gene

This gene is overexpressed in Liver (35.5), Plasma (13.9), and Blymphocyte (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM214A Gene

Protein tissue co-expression partners for FAM214A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM214A

SOURCE GeneReport for Unigene cluster for FAM214A Gene:


Evidence on tissue expression from TISSUES for FAM214A Gene

  • Blood(5)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with FAM214A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM214A Gene

Orthologs for FAM214A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM214A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM214A 31 30
  • 99.54 (n)
(Canis familiaris)
Mammalia KIAA1370 30
  • 90.16 (n)
FAM214A 31
  • 84 (a)
(Bos Taurus)
Mammalia KIAA1370 30
  • 89.9 (n)
FAM214A 31
  • 84 (a)
(Rattus norvegicus)
Mammalia Fam214a 30
  • 78.81 (n)
(Mus musculus)
Mammalia Fam214a 17 31 30
  • 78.39 (n)
(Monodelphis domestica)
Mammalia FAM214A 31
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia FAM214A 31
  • 67 (a)
(Gallus gallus)
Aves FAM214A 31 30
  • 72.61 (n)
(Anolis carolinensis)
Reptilia FAM214A 31
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2731 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6950 30
(Danio rerio)
Actinopterygii fam214a 31
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9005 31
  • 15 (a)
Species where no ortholog for FAM214A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM214A Gene

Gene Tree for FAM214A (if available)
Gene Tree for FAM214A (if available)
Evolutionary constrained regions (ECRs) for FAM214A: view image

Paralogs for FAM214A Gene

Paralogs for FAM214A Gene

(3) SIMAP similar genes for FAM214A Gene using alignment to 9 proteins:

  • F214A_HUMAN
  • H0Y3Q9_HUMAN
  • H3BQ29_HUMAN
  • H3BU00_HUMAN
genes like me logo Genes that share paralogs with FAM214A: view

Variants for FAM214A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM214A Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs12915981 - p.Val560Ile
rs8036680 - p.Gln135Arg

Additional dbSNP identifiers (rs#s) for FAM214A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM214A Gene

Variant ID Type Subtype PubMed ID
esv1977718 CNV deletion 18987734
esv2749699 CNV deletion 23290073
esv2749700 CNV deletion 23290073
esv3382591 CNV insertion 20981092
esv3636490 CNV loss 21293372
nsv1047775 CNV gain 25217958
nsv457140 CNV loss 19166990
nsv471245 CNV gain 18288195
nsv833006 CNV gain 17160897

Variation tolerance for FAM214A Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM214A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM214A Gene

Disorders for FAM214A Gene

Additional Disease Information for FAM214A

No disorders were found for FAM214A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM214A Gene

Publications for FAM214A Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 54
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S … Ideker T (Nature methods 2010) 3 54

Products for FAM214A Gene

  • Signalway ELISA kits for FAM214A
  • Signalway Proteins for FAM214A

Sources for FAM214A Gene