Aliases for FAM210B Gene

Aliases for FAM210B Gene

  • Family With Sequence Similarity 210 Member B 2 3 5
  • Protein FAM210B, Mitochondrial 3 4
  • DJ1167H4.1 2 3
  • C20orf108 3 4
  • Family With Sequence Similarity 210, Member B 2
  • Chromosome 20 Open Reading Frame 108 2
  • Transmembrane Protein C20orf108 3
  • Hypothetical Protein LOC116151 2
  • Protein FAM210B 3
  • DKFZP434A1114 2
  • FAM210B 5
  • 5A3 3

External Ids for FAM210B Gene

Previous HGNC Symbols for FAM210B Gene

  • C20orf108

Previous GeneCards Identifiers for FAM210B Gene

  • GC20P054934

Summaries for FAM210B Gene

GeneCards Summary for FAM210B Gene

FAM210B (Family With Sequence Similarity 210 Member B) is a Protein Coding gene. Diseases associated with FAM210B include Ovarian Cancer. An important paralog of this gene is FAM210A.

UniProtKB/Swiss-Prot Summary for FAM210B Gene

  • Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).

Additional gene information for FAM210B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM210B Gene

Genomics for FAM210B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM210B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J056358 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 617 +2.4 2398 6.1 SP1 HNRNPL GATAD2A LEF1 IKZF1 RCOR2 ZNF7 TARDBP JUND FOXA1 FAM210B AURKA CSTF1 lnc-CSTF1-1
GH20J056408 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 +58.1 58140 17 CEBPG GATAD2A YBX1 PRDM10 REST LEF1 IKZF1 ETV6 JUND GABPA CASS4 RTF2 CSTF1 RAE1 RPL39P ENSG00000280387 FAM210B GCNT7 FAM209B HSALNG0131068
GH20J056426 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 10.4 +70.0 69952 5.8 RFX1 IKZF1 JUND MTA2 ZNF24 MTA1 DPF2 HDAC1 ETV6 TCF12 RF00017-3645 CASS4 RTF2 RPL39P FAM209A FAM210B
GH20J056348 Enhancer 0.8 Ensembl ENCODE 14.1 -10.8 -10773 1.2 RXRB SP1 TCF7L2 FOXA2 MAFF YY1 CREB1 MAFK SAP130 ZNF335 FAM210B piR-61240-156 MC3R
GH20J056343 Enhancer 0.6 Ensembl 14.6 -15.0 -14973 0.8 CTCF JUND REST RAD21 TRIM22 EZH2 ZNF766 SMC3 GABPB1 CBX5 FAM210B piR-61240-156 MC3R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM210B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM210B

Genomic Locations for FAM210B Gene

Genomic Locations for FAM210B Gene
chr20:56,358,974-56,368,663
(GRCh38/hg38)
Size:
9,690 bases
Orientation:
Plus strand
chr20:54,933,971-54,943,719
(GRCh37/hg19)
Size:
9,749 bases
Orientation:
Plus strand

Genomic View for FAM210B Gene

Genes around FAM210B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM210B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM210B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM210B Gene

Proteins for FAM210B Gene

  • Protein details for FAM210B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KR6-F210B_HUMAN
    Recommended name:
    Protein FAM210B, mitochondrial
    Protein Accession:
    Q96KR6
    Secondary Accessions:
    • B2RBQ9
    • E1P5Y7
    • Q8WVN2
    • Q9BYL6
    • Q9H418

    Protein attributes for FAM210B Gene

    Size:
    192 amino acids
    Molecular mass:
    20424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM210B Gene

Post-translational modifications for FAM210B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM210B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM210B Gene

Domains & Families for FAM210B Gene

Gene Families for FAM210B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM210B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM210B Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 20 open reading frame 108 (A6ZKI2_HUMAN)
  • Transmembrane protein C20orf108 (CT108_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KR6

UniProtKB/Swiss-Prot:

F210B_HUMAN :
  • Belongs to the FAM210 family.
Family:
  • Belongs to the FAM210 family.
genes like me logo Genes that share domains with FAM210B: view

Function for FAM210B Gene

Molecular function for FAM210B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).
UniProtKB/Swiss-Prot Induction:
Up-regulated by the erythroid transcription factor GATA1 (PubMed:26968549).

Phenotypes From GWAS Catalog for FAM210B Gene

genes like me logo Genes that share phenotypes with FAM210B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM210B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM210B Gene

Localization for FAM210B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM210B Gene

Mitochondrion. Mitochondrion outer membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM210B gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
extracellular 2
cytosol 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM210B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA,IDA 26968549
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031224 intrinsic component of membrane IDA 26968549
genes like me logo Genes that share ontologies with FAM210B: view

Pathways & Interactions for FAM210B Gene

PathCards logo

SuperPathways for FAM210B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM210B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
GO:0043249 erythrocyte maturation IEA --
GO:0045648 positive regulation of erythrocyte differentiation IMP 26968549
GO:0071392 cellular response to estradiol stimulus IDA 26968549
genes like me logo Genes that share ontologies with FAM210B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM210B Gene

Drugs & Compounds for FAM210B Gene

No Compound Related Data Available

Transcripts for FAM210B Gene

mRNA/cDNA for FAM210B Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM210B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM210B Gene

No ASD Table

Relevant External Links for FAM210B Gene

GeneLoc Exon Structure for
FAM210B

Expression for FAM210B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM210B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM210B Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for FAM210B Gene

This gene is overexpressed in Hair follicle (12.4) and Adrenal (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM210B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM210B

SOURCE GeneReport for Unigene cluster for FAM210B Gene:

Hs.143736

mRNA Expression by UniProt/SwissProt for FAM210B Gene:

Q96KR6-F210B_HUMAN
Tissue specificity: Expressed in late erythroblast differentiation stages (PubMed:26968549). Underexpressed in ovarian cancer epithelia cells compared with normal human ovarian surface epithelia (PubMed:28594398).

Evidence on tissue expression from TISSUES for FAM210B Gene

  • Liver(4.4)
  • Lung(4.4)
  • Nervous system(3)
  • Skin(2.9)
  • Heart(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with FAM210B: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM210B Gene

Orthologs for FAM210B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM210B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM210B 30 31
  • 98.96 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM210B 30 31
  • 85.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM210B 30
  • 83.85 (n)
C13H20ORF108 31
  • 83 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Fam210b 30 17 31
  • 77.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam210b 30
  • 76.49 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM210B 31
  • 73 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM210B 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C20H20ORF108 30 31
  • 67.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM210B 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam210b 30
  • 60.31 (n)
Str.15729 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18665 30
Zebrafish
(Danio rerio)
Actinopterygii fam210b 31
  • 38 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG15403 31
  • 33 (a)
OneToMany
CG17508 31
  • 21 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6707 31
  • 25 (a)
OneToOne
Species where no ortholog for FAM210B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM210B Gene

ENSEMBL:
Gene Tree for FAM210B (if available)
TreeFam:
Gene Tree for FAM210B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM210B: view image

Paralogs for FAM210B Gene

Paralogs for FAM210B Gene

Pseudogenes.org Pseudogenes for FAM210B Gene

genes like me logo Genes that share paralogs with FAM210B: view

Variants for FAM210B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM210B Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs6099115 - p.Pro126Ser

Additional dbSNP identifiers (rs#s) for FAM210B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM210B Gene

Variant ID Type Subtype PubMed ID
dgv2269n106 CNV deletion 24896259
nsv522197 CNV loss 19592680
nsv526373 CNV loss 19592680
nsv828755 CNV gain 20364138
nsv828756 CNV gain 20364138
nsv834013 CNV gain 17160897
nsv964411 CNV duplication 23825009

Variation tolerance for FAM210B Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.96; 83.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM210B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM210B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM210B Gene

Disorders for FAM210B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM210B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with FAM210B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM210B Gene

Publications for FAM210B Gene

  1. Identification of a novel putative mitochondrial protein FAM210B associated with erythroid differentiation. (PMID: 26968549) Kondo A … Harigae H (International journal of hematology 2016) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 2 3 4
  3. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. (PMID: 30366982) Yien YY … Paw BH (The Journal of biological chemistry 2018) 2 3
  4. Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming. (PMID: 28594398) Sun S … Wu P (Cell death & disease 2017) 3 4
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4

Products for FAM210B Gene

Sources for FAM210B Gene