Aliases for FAM20B Gene
External Ids for FAM20B Gene
Previous GeneCards Identifiers for FAM20B Gene
GeneCards Summary for FAM20B Gene
FAM20B (FAM20B Glycosaminoglycan Xylosylkinase) is a Protein Coding gene. Diseases associated with FAM20B include Dental Pulp Calcification and Desbuquois Dysplasia. Gene Ontology (GO) annotations related to this gene include kinase activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is FAM20C.
UniProtKB/Swiss-Prot Summary for FAM20B Gene
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.