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Aliases for FAM207A Gene

Aliases for FAM207A Gene

  • Family With Sequence Similarity 207 Member A 2 3 5
  • C21orf70 3 4
  • Family With Sequence Similarity 207, Member A 2
  • Chromosome 21 Open Reading Frame 70 2
  • Protein FAM207A 3
  • PRED56 3

External Ids for FAM207A Gene

Previous HGNC Symbols for FAM207A Gene

  • C21orf70

Previous GeneCards Identifiers for FAM207A Gene

  • GC21P046360

Summaries for FAM207A Gene

GeneCards Summary for FAM207A Gene

FAM207A (Family With Sequence Similarity 207 Member A) is a Protein Coding gene.

Additional gene information for FAM207A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM207A Gene

Genomics for FAM207A Gene

GeneHancer (GH) Regulatory Elements for FAM207A Gene

Promoters and enhancers for FAM207A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I044938 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557.7 +0.5 482 3 MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ZNF610 LINC01547 FAM207A ENSG00000215447 PWP2 ENSG00000184441 LINC00205 ENSG00000273027 UBE2G2 ITGB2-AS1 TRAPPC10
GH21I044966 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.8 +28.8 28814 4.6 ATF1 BRCA1 ETS1 YY1 TCF12 GLIS2 GATA2 ATF7 RXRA ZHX2 ENSG00000273027 ITGB2 LINC01547 FAM207A ITGB2-AS1 POFUT2 ENSG00000276529
GH21I044984 Enhancer 1.2 Ensembl ENCODE dbSUPER 8.2 +45.1 45082 1.3 MLX ARID4B DMAP1 RAD21 DNMT3B ZNF48 RARA SP5 NFYC ELF1 SSR4P1 ADARB1 LINC00163 LINC01547 FAM207A LINC00165 ENSG00000276529
GH21I044983 Enhancer 1.2 Ensembl ENCODE dbSUPER 7.8 +43.2 43167 1.6 FOXA2 RAD21 THRB ZNF48 RARA EGR1 HSF1 FOS THAP11 EGR2 SSR4P1 ADARB1 ITGB2-AS1 LINC01547 FAM207A ENSG00000276529 LINC00163
GH21I044957 Enhancer 1 Ensembl ENCODE dbSUPER 7.5 +19.0 18963 3.4 SCRT1 RFX1 RXRA MAX RAD21 NR2F2 SCRT2 HNF4A EGR2 ENSG00000273027 ADARB1 SSR4P1 LINC01424 UBE2G2 SUMO3 LINC01547 TSPEAR-AS2 LINC00334 ITGB2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM207A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM207A Gene

Genomic Locations for FAM207A Gene
chr21:44,939,998-44,976,989
(GRCh38/hg38)
Size:
36,992 bases
Orientation:
Plus strand
chr21:46,359,925-46,396,904
(GRCh37/hg19)

Genomic View for FAM207A Gene

Genes around FAM207A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM207A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM207A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM207A Gene

Proteins for FAM207A Gene

  • Protein details for FAM207A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSI2-F207A_HUMAN
    Recommended name:
    Protein FAM207A
    Protein Accession:
    Q9NSI2

    Protein attributes for FAM207A Gene

    Size:
    230 amino acids
    Molecular mass:
    25456 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM207A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM207A Gene

Post-translational modifications for FAM207A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM207A Gene

Domains & Families for FAM207A Gene

Gene Families for FAM207A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM207A Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NSI2

UniProtKB/Swiss-Prot:

F207A_HUMAN :
  • Belongs to the FAM207 family.
Family:
  • Belongs to the FAM207 family.
genes like me logo Genes that share domains with FAM207A: view

No data available for Suggested Antigen Peptide Sequences for FAM207A Gene

Function for FAM207A Gene

Gene Ontology (GO) - Molecular Function for FAM207A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM207A: view
genes like me logo Genes that share phenotypes with FAM207A: view

Animal Model Products

miRNA for FAM207A Gene

miRTarBase miRNAs that target FAM207A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM207A Gene

Localization for FAM207A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM207A gene
Compartment Confidence
nucleus 3
golgi apparatus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM207A Gene

Pathways & Interactions for FAM207A Gene

SuperPathways for FAM207A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM207A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM207A Gene

Drugs & Compounds for FAM207A Gene

No Compound Related Data Available

Transcripts for FAM207A Gene

Unigene Clusters for FAM207A Gene

Family with sequence similarity 207, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM207A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: -
SP7:

Relevant External Links for FAM207A Gene

GeneLoc Exon Structure for
FAM207A
ECgene alternative splicing isoforms for
FAM207A

Expression for FAM207A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM207A Gene

Protein differential expression in normal tissues from HIPED for FAM207A Gene

This gene is overexpressed in Bone (23.6), Platelet (16.3), and Lung (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM207A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM207A Gene:

FAM207A

SOURCE GeneReport for Unigene cluster for FAM207A Gene:

Hs.410830

mRNA Expression by UniProt/SwissProt for FAM207A Gene:

Q9NSI2-F207A_HUMAN
Tissue specificity: Not detected in any tested tissue.
genes like me logo Genes that share expression patterns with FAM207A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM207A Gene

Orthologs for FAM207A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM207A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM207A 33 34
  • 97.39 (n)
dog
(Canis familiaris)
Mammalia FAM207A 33 34
  • 82.48 (n)
cow
(Bos Taurus)
Mammalia FAM207A 33
  • 81.93 (n)
C1H21ORF70 34
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam207a 33
  • 80.31 (n)
mouse
(Mus musculus)
Mammalia Fam207a 33 16 34
  • 79.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM207A 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM207A 33 34
  • 58.97 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam207a 33
  • 53.53 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-84a8.8 33
  • 50.16 (n)
fam207a 34
  • 32 (a)
OneToOne
Species where no ortholog for FAM207A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM207A Gene

ENSEMBL:
Gene Tree for FAM207A (if available)
TreeFam:
Gene Tree for FAM207A (if available)

Paralogs for FAM207A Gene

genes like me logo Genes that share paralogs with FAM207A: view

No data available for Paralogs for FAM207A Gene

Variants for FAM207A Gene

Sequence variations from dbSNP and Humsavar for FAM207A Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000072434 -- 44,959,698(+) G/A intron_variant
rs1000146787 -- 44,939,340(+) A/C upstream_transcript_variant
rs1000181678 -- 44,957,955(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000298841 -- 44,955,651(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000337633 -- 44,951,678(+) A/C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM207A Gene

Variant ID Type Subtype PubMed ID
nsv953650 CNV deletion 24416366
nsv953649 CNV deletion 24416366
nsv834110 CNV loss 17160897
nsv187379 CNV insertion 16902084
nsv1132908 CNV insertion 24896259
nsv1114299 CNV deletion 24896259
esv3647139 CNV loss 21293372
esv3647138 CNV loss 21293372
esv3557827 CNV deletion 23714750
esv3332159 CNV insertion 20981092
esv2723698 CNV deletion 23290073
esv2670703 CNV deletion 23128226
esv2658603 CNV deletion 23128226
esv2218502 CNV deletion 18987734
esv1168895 CNV insertion 17803354

Variation tolerance for FAM207A Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM207A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM207A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM207A Gene

Disorders for FAM207A Gene

Additional Disease Information for FAM207A

No disorders were found for FAM207A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM207A Gene

Publications for FAM207A Gene

  1. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A … Antonarakis SE (Genomics 2001) 3 4 22 58
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FAM207A Gene

Sources for FAM207A Gene

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