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Aliases for FAM205A Gene

Aliases for FAM205A Gene

  • Family With Sequence Similarity 205 Member A 2 3 5
  • Protein FAM205A 3 4
  • C9orf144B 3 4
  • Family With Sequence Similarity 205, Member A 2
  • Transmembrane Protein C9orf144B 3

External Ids for FAM205A Gene

Summaries for FAM205A Gene

GeneCards Summary for FAM205A Gene

FAM205A (Family With Sequence Similarity 205 Member A) is a Protein Coding gene. An important paralog of this gene is SPATA31D1.

Additional gene information for FAM205A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM205A Gene

Genomics for FAM205A Gene

GeneHancer (GH) Regulatory Elements for FAM205A Gene

Promoters and enhancers for FAM205A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J034987 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.9 -263.7 -263744 10.6 SP1 CC2D1A CTCF MNT SIX5 CBFA2T2 ZNF148 NKRF CEBPG ZNF687 DNAJB5 VCP UBAP2 ARHGEF39 TPM2 FANCG CCDC107 TLN1 YBX1P10 PIGO
GH09J035069 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.9 -342.3 -342333 4.1 SP1 CC2D1A ZFX NKRF POLR2A GTF2F1 CSDE1 ZNF687 FOS AHR VCP FANCG TMEM8B FAM205A C9orf131 ATP8B5P NPR2 RN7SL338P
GH09J034326 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 +400.6 400566 4.9 SP1 ZFX MNT NKRF POLR2A GTF2F1 CSDE1 ZSCAN21 FOS MAFK NUDT2 UBAP2 NOL6 VCP MYORG C9orf24 CCL21 FAM205A PIGO C9orf131
GH09J034619 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 12 +109.3 109337 2 SP1 ZFX NKRF POLR2A ELF1 CREM KAT8 CREB1 PKNOX1 RFX1 DCTN3 UBAP2 RPP25L FAM205A C9orf131 ATP8B5P VCP SIGMAR1
GH09J033867 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 +861.1 861137 2.8 MAFK ZNF680 ZBTB8A PRDM12 ZNF629 ZNF501 ZNF140 ZNF316 ZXDB ZNF266 GC09P034446 RNU4ATAC11P ASS1P12 NOL6 NFX1 ENSG00000228352 TCEA1P4 SMU1 UBAP2 FAM205A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM205A on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM205A Gene

Genomic Locations for FAM205A Gene
chr9:34,723,053-34,729,538
(GRCh38/hg38)
Size:
6,486 bases
Orientation:
Minus strand
chr9:34,723,050-34,729,535
(GRCh37/hg19)
Size:
6,486 bases
Orientation:
Minus strand

Genomic View for FAM205A Gene

Genes around FAM205A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM205A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM205A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM205A Gene

Proteins for FAM205A Gene

  • Protein details for FAM205A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU69-F205A_HUMAN
    Recommended name:
    Protein FAM205A
    Protein Accession:
    Q6ZU69
    Secondary Accessions:
    • A8MVW7

    Protein attributes for FAM205A Gene

    Size:
    1335 amino acids
    Molecular mass:
    148096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86357.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM205A Gene

Post-translational modifications for FAM205A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM205A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM205A Gene

Domains & Families for FAM205A Gene

Gene Families for FAM205A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM205A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM205A Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein C9orf144B (CI14B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZU69

UniProtKB/Swiss-Prot:

F205A_HUMAN :
  • Belongs to the FAM205 family.
Family:
  • Belongs to the FAM205 family.
genes like me logo Genes that share domains with FAM205A: view

Function for FAM205A Gene

Phenotypes From GWAS Catalog for FAM205A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM205A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM205A Gene

Localization for FAM205A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM205A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM205A gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for FAM205A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM205A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM205A Gene

Pathways & Interactions for FAM205A Gene

PathCards logo

SuperPathways for FAM205A Gene

No Data Available

Interacting Proteins for FAM205A Gene

Gene Ontology (GO) - Biological Process for FAM205A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM205A Gene

Drugs & Compounds for FAM205A Gene

No Compound Related Data Available

Transcripts for FAM205A Gene

mRNA/cDNA for FAM205A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for FAM205A Gene

Family with sequence similarity 205, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM205A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM205A Gene

No ASD Table

Relevant External Links for FAM205A Gene

GeneLoc Exon Structure for
FAM205A
ECgene alternative splicing isoforms for
FAM205A

Expression for FAM205A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM205A Gene

mRNA differential expression in normal tissues according to GTEx for FAM205A Gene

This gene is overexpressed in Testis (x48.5).

Protein differential expression in normal tissues from HIPED for FAM205A Gene

This gene is overexpressed in Testis (57.3) and Ovary (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM205A Gene



Protein tissue co-expression partners for FAM205A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM205A Gene:

FAM205A

SOURCE GeneReport for Unigene cluster for FAM205A Gene:

Hs.522093
genes like me logo Genes that share expression patterns with FAM205A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM205A Gene

Orthologs for FAM205A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM205A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC746223 34
  • 98.75 (n)
FAM205A 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM205A 35 34
  • 78.21 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam205a 34
  • 67.2 (n)
mouse
(Mus musculus)
Mammalia LOC100862324 34
  • 67.13 (n)
OTTMUSG00000011338 35
  • 47 (a)
OneToMany
CT868723.2 35
  • 47 (a)
OneToMany
Gm3883 35
  • 47 (a)
OneToMany
Gm21093 35
  • 47 (a)
OneToMany
Gm12394 35
  • 46 (a)
OneToMany
Gm20938 35
  • 45 (a)
OneToMany
Gm21598 35
  • 45 (a)
OneToMany
CR974586.7 35
  • 45 (a)
OneToMany
Gm12429 35
  • 45 (a)
OneToMany
FAM205A 35
  • 45 (a)
OneToMany
Gm13298 35
  • 45 (a)
OneToMany
GM7819 35
  • 44 (a)
OneToMany
Gm2163 35
  • 44 (a)
OneToMany
CR974586.1 35
  • 43 (a)
OneToMany
Gm10600 35
  • 36 (a)
OneToMany
BC049635 35
  • 31 (a)
OneToMany
Fam205a4 17
cow
(Bos Taurus)
Mammalia -- 35
  • 62 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FAM205A 35
  • 35 (a)
OneToOne
Species where no ortholog for FAM205A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM205A Gene

ENSEMBL:
Gene Tree for FAM205A (if available)
TreeFam:
Gene Tree for FAM205A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM205A: view image

Paralogs for FAM205A Gene

(1) SIMAP similar genes for FAM205A Gene using alignment to 1 proteins:

  • F205A_HUMAN

Pseudogenes.org Pseudogenes for FAM205A Gene

genes like me logo Genes that share paralogs with FAM205A: view

Variants for FAM205A Gene

Sequence variations from dbSNP and Humsavar for FAM205A Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs373701758 benign, Abnormality of neuronal migration 34,723,621(-) T/G coding_sequence_variant, missense_variant
rs374244221 benign, Abnormality of neuronal migration 34,723,254(-) T/G coding_sequence_variant, missense_variant
rs527869852 benign, Abnormality of neuronal migration 34,724,686(-) C/T coding_sequence_variant, missense_variant
rs548036648 benign, Abnormality of neuronal migration 34,724,788(-) C/A/T coding_sequence_variant, missense_variant
rs571906331 benign, Abnormality of neuronal migration 34,724,301(-) T/A/C/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM205A Gene

Variant ID Type Subtype PubMed ID
dgv1337e199 CNV deletion 23128226
esv2738389 CNV deletion 23290073
esv3576650 CNV gain 25503493
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv509301 CNV insertion 20534489
nsv614157 CNV loss 21841781
nsv831544 CNV gain 17160897
nsv972309 CNV duplication 23825009

Variation tolerance for FAM205A Gene

Gene Damage Index Score: 22.70; 99.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM205A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM205A
Human Gene Mutation Database (HGMD)
FAM205A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM205A Gene

Disorders for FAM205A Gene

Additional Disease Information for FAM205A

No disorders were found for FAM205A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM205A Gene

Publications for FAM205A Gene

  1. Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. (PMID: 29930801) Yamada Y … Sakuma J (Biomedical reports 2018) 2 3 58
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58

Products for FAM205A Gene

Sources for FAM205A Gene

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