Aliases for FAM205A Gene

Aliases for FAM205A Gene

  • Family With Sequence Similarity 205 Member A 2 3 5
  • C9orf144B 2 3 4
  • Protein FAM205A 3 4
  • Family With Sequence Similarity 205, Member A 2
  • Transmembrane Protein C9orf144B 3
  • FAM205A 5

External Ids for FAM205A Gene

Summaries for FAM205A Gene

GeneCards Summary for FAM205A Gene

FAM205A (Family With Sequence Similarity 205 Member A) is a Protein Coding gene. An important paralog of this gene is SPATA31D1.

Additional gene information for FAM205A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM205A Gene

Genomics for FAM205A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM205A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J033867 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 +861.6 861587 3.4 ZNF629 ZNF501 ZNF140 ZXDB CEBPB ZNF316 MAFF ZNF266 MAFK ZBTB17 FJ601684-454 RNU4ATAC11P RF00618-015 NOL6 ASS1P12 ENSG00000228352 NFX1 TCEA1P4 SMU1 UBAP2
GH09J034162 Enhancer 1 Ensembl ENCODE 10.9 +566.3 566318 2.1 CREB1 ZNF629 ATF7 RBAK CEBPB ZNF140 SP1 ZNF639 ZXDB CTBP1 PIGO NOL6 NFX1 ENSG00000228352 UBAP2 NUDT2 FANCG ENSG00000239392 DCAF12 FAM205A
GH09J034709 Promoter/Enhancer 0.7 EPDnew Ensembl ENCODE 10.4 +20.0 19987 2.6 CCL21 FAM205BP IL11RA GALT FAM205A RPP25L GLULP4 ENSG00000288583 CCL19
GH09J034743 Enhancer 0.6 Ensembl ENCODE 8.5 -15.7 -15743 2.5 PKNOX1 FOS MEIS2 JUND CCL21 CCL19 PHF24 FAM205A piR-58297-493 piR-60985-131 ENSG00000288583
GH09J034741 Enhancer 0.5 Ensembl 6.7 -12.3 -12313 0.4 CEBPB SPI1 ATF4 CEBPG ATF3 ZNF148 piR-31470-516 piR-39099-281 piR-58297-493 CCL19 PHF24 FAM205A piR-60985-131 ENSG00000288583
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM205A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM205A

Genomic Locations for FAM205A Gene

Genomic Locations for FAM205A Gene
chr9:34,723,053-34,729,488
(GRCh38/hg38)
Size:
6,436 bases
Orientation:
Minus strand
chr9:34,723,050-34,729,535
(GRCh37/hg19)
Size:
6,486 bases
Orientation:
Minus strand

Genomic View for FAM205A Gene

Genes around FAM205A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM205A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM205A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM205A Gene

Proteins for FAM205A Gene

  • Protein details for FAM205A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU69-F205A_HUMAN
    Recommended name:
    Protein FAM205A
    Protein Accession:
    Q6ZU69
    Secondary Accessions:
    • A8MVW7

    Protein attributes for FAM205A Gene

    Size:
    1335 amino acids
    Molecular mass:
    148096 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86357.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM205A Gene

Post-translational modifications for FAM205A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM205A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM205A Gene

Domains & Families for FAM205A Gene

Gene Families for FAM205A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM205A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM205A Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein C9orf144B (CI14B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZU69

UniProtKB/Swiss-Prot:

F205A_HUMAN :
  • Belongs to the FAM205 family.
Family:
  • Belongs to the FAM205 family.
genes like me logo Genes that share domains with FAM205A: view

Function for FAM205A Gene

Phenotypes From GWAS Catalog for FAM205A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM205A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM205A Gene

Localization for FAM205A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM205A Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM205A gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for FAM205A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM205A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM205A Gene

Pathways & Interactions for FAM205A Gene

PathCards logo

SuperPathways for FAM205A Gene

No Data Available

Interacting Proteins for FAM205A Gene

Gene Ontology (GO) - Biological Process for FAM205A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM205A Gene

Drugs & Compounds for FAM205A Gene

No Compound Related Data Available

Transcripts for FAM205A Gene

mRNA/cDNA for FAM205A Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM205A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM205A Gene

No ASD Table

Relevant External Links for FAM205A Gene

GeneLoc Exon Structure for
FAM205A

Expression for FAM205A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM205A Gene

mRNA differential expression in normal tissues according to GTEx for FAM205A Gene

This gene is overexpressed in Testis (x48.5).

Protein differential expression in normal tissues from HIPED for FAM205A Gene

This gene is overexpressed in Testis (57.3) and Ovary (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM205A Gene



Protein tissue co-expression partners for FAM205A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM205A

SOURCE GeneReport for Unigene cluster for FAM205A Gene:

Hs.522093
genes like me logo Genes that share expression patterns with FAM205A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM205A Gene

Orthologs for FAM205A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM205A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC746223 30
  • 98.75 (n)
FAM205A 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM205A 30 31
  • 78.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam205a 30
  • 67.2 (n)
Mouse
(Mus musculus)
Mammalia Gm13298 30 31
  • 67.13 (n)
OneToMany
OTTMUSG00000011338 31
  • 47 (a)
OneToMany
CT868723.2 31
  • 47 (a)
OneToMany
Gm3883 31
  • 47 (a)
OneToMany
Gm21093 31
  • 47 (a)
OneToMany
Gm12394 31
  • 46 (a)
OneToMany
Gm20938 31
  • 45 (a)
OneToMany
Gm21598 31
  • 45 (a)
OneToMany
CR974586.7 31
  • 45 (a)
OneToMany
Gm12429 31
  • 45 (a)
OneToMany
FAM205A 31
  • 45 (a)
OneToMany
GM7819 31
  • 44 (a)
OneToMany
Gm2163 31
  • 44 (a)
OneToMany
CR974586.1 31
  • 43 (a)
OneToMany
Gm10600 31
  • 36 (a)
OneToMany
BC049635 31
  • 31 (a)
OneToMany
Fam205a1 17
Fam205a2 17
Fam205a3 17
Fam205a4 17
Cow
(Bos Taurus)
Mammalia -- 31
  • 62 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia FAM205A 31
  • 35 (a)
OneToOne
Species where no ortholog for FAM205A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FAM205A Gene

ENSEMBL:
Gene Tree for FAM205A (if available)
TreeFam:
Gene Tree for FAM205A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM205A: view image

Paralogs for FAM205A Gene

(1) SIMAP similar genes for FAM205A Gene using alignment to 1 proteins:

  • F205A_HUMAN

Pseudogenes.org Pseudogenes for FAM205A Gene

genes like me logo Genes that share paralogs with FAM205A: view

Variants for FAM205A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM205A Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
719346 Benign: not provided 34,729,341(-) C/A MISSENSE_VARIANT
rs373701758 Benign: Abnormality of neuronal migration 34,723,621(-) T/G MISSENSE_VARIANT
rs374244221 Benign: Abnormality of neuronal migration 34,723,254(-) T/G MISSENSE_VARIANT
rs472644 Benign: not specified 34,724,062(-) G/A MISSENSE_VARIANT
rs527869852 Benign: Abnormality of neuronal migration 34,724,686(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FAM205A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM205A Gene

Variant ID Type Subtype PubMed ID
dgv1337e199 CNV deletion 23128226
esv2738389 CNV deletion 23290073
esv3576650 CNV gain 25503493
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv509301 CNV insertion 20534489
nsv614157 CNV loss 21841781
nsv831544 CNV gain 17160897
nsv972309 CNV duplication 23825009

Variation tolerance for FAM205A Gene

Gene Damage Index Score: 22.70; 99.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM205A Gene

Human Gene Mutation Database (HGMD)
FAM205A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM205A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM205A Gene

Disorders for FAM205A Gene

No disorders were found for FAM205A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM205A Gene

Publications for FAM205A Gene

  1. Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. (PMID: 29930801) Yamada Y … Sakuma J (Biomedical reports 2018) 2 3
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

Products for FAM205A Gene

Sources for FAM205A Gene