Aliases for FAM200B Gene

Aliases for FAM200B Gene

  • Family With Sequence Similarity 200 Member B 2 3 5
  • C4orf53 2 3 4
  • Protein FAM200B 3 4
  • Family With Sequence Similarity 200, Member B 2
  • Chromosome 4 Open Reading Frame 53 2
  • Putative Protein FAM200B 3
  • FAM200B 5

External Ids for FAM200B Gene

Previous GeneCards Identifiers for FAM200B Gene

  • GC04P015683
  • GC04P015033

Summaries for FAM200B Gene

GeneCards Summary for FAM200B Gene

FAM200B (Family With Sequence Similarity 200 Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is FAM200A.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM200B Gene

Genomics for FAM200B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM200B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM200B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM200B

Genomic Locations for FAM200B Gene

Latest Assembly
chr4:15,651,521-15,690,447
(GRCh38/hg38)
Size:
38,927 bases
Orientation:
Plus strand

Previous Assembly
chr4:15,683,450-15,692,070
(GRCh37/hg19 by Entrez Gene)
Size:
8,621 bases
Orientation:
Plus strand

chr4:15,683,285-15,707,188
(GRCh37/hg19 by Ensembl)
Size:
23,904 bases
Orientation:
Plus strand

Genomic View for FAM200B Gene

Genes around FAM200B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM200B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM200B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM200B Gene

Proteins for FAM200B Gene

  • Protein details for FAM200B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CF97-F200B_HUMAN
    Recommended name:
    Protein FAM200B
    Protein Accession:
    P0CF97

    Protein attributes for FAM200B Gene

    Size:
    657 amino acids
    Molecular mass:
    76034 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM200B Gene

Post-translational modifications for FAM200B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM200B Gene

Domains & Families for FAM200B Gene

Gene Families for FAM200B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM200B Gene

InterPro:

Suggested Antigen Peptide Sequences for FAM200B Gene

GenScript: Design optimal peptide antigens:
  • Putative protein FAM200B (F200B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CF97

UniProtKB/Swiss-Prot:

F200B_HUMAN :
  • Belongs to the FAM200 family.
Family:
  • Belongs to the FAM200 family.
genes like me logo Genes that share domains with FAM200B: view

Function for FAM200B Gene

Phenotypes From GWAS Catalog for FAM200B Gene

Phenotypes for FAM200B Gene

genes like me logo Genes that share phenotypes with FAM200B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM200B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM200B Gene

Localization for FAM200B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM200B gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM200B Gene

Pathways & Interactions for FAM200B Gene

PathCards logo

SuperPathways for FAM200B Gene

No Data Available

Interacting Proteins for FAM200B Gene

Gene Ontology (GO) - Biological Process for FAM200B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM200B Gene

Drugs & Compounds for FAM200B Gene

No Compound Related Data Available

Transcripts for FAM200B Gene

mRNA/cDNA for FAM200B Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM200B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM200B Gene

No ASD Table

Relevant External Links for FAM200B Gene

GeneLoc Exon Structure for
FAM200B

Expression for FAM200B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM200B Gene

Protein differential expression in normal tissues from HIPED for FAM200B Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM200B Gene



Protein tissue co-expression partners for FAM200B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM200B

SOURCE GeneReport for Unigene cluster for FAM200B Gene:

Hs.399980

Evidence on tissue expression from TISSUES for FAM200B Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with FAM200B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM200B Gene

Orthologs for FAM200B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM200B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM200B 29
  • 99.64 (n)
Dog
(Canis familiaris)
Mammalia FAM200B 29
  • 92.54 (n)
Cow
(Bos Taurus)
Mammalia FAM200B 29
  • 86.78 (n)
Mouse
(Mus musculus)
Mammalia 2410018M08Rik 30
  • 28 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 28 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii BX927234.1 30
  • 28 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 24 (a)
ManyToMany
Species where no ortholog for FAM200B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM200B Gene

ENSEMBL:
Gene Tree for FAM200B (if available)
TreeFam:
Gene Tree for FAM200B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM200B: view image
Alliance of Genome Resources:
Additional Orthologs for FAM200B

Paralogs for FAM200B Gene

(3) SIMAP similar genes for FAM200B Gene using alignment to 2 proteins:

  • F200B_HUMAN
  • D6RAC6_HUMAN
genes like me logo Genes that share paralogs with FAM200B: view

Variants for FAM200B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM200B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM200B Gene

Variant ID Type Subtype PubMed ID
dgv315n21 CNV loss 19592680
esv2759227 CNV gain+loss 17122850
nsv428439 CNV gain+loss 18775914
nsv949802 CNV duplication 24416366

Variation tolerance for FAM200B Gene

Gene Damage Index Score: 10.10; 90.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM200B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM200B
Leiden Open Variation Database (LOVD)
FAM200B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM200B Gene

Disorders for FAM200B Gene

Additional Disease Information for FAM200B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for FAM200B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM200B Gene

Publications for FAM200B Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  2. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. (PMID: 27609421) Banks CA … Washburn MP (Molecular & cellular proteomics : MCP 2016) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn LW … O'Brien SJ (The Journal of infectious diseases 2010) 40
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass AL … Elledge SJ (Science (New York, N.Y.) 2008) 3

Products for FAM200B Gene

Sources for FAM200B Gene