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Aliases for FAM19A5 Gene

Aliases for FAM19A5 Gene

  • Family With Sequence Similarity 19 Member A5, C-C Motif Chemokine Like 2 3 5
  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A5 2 3
  • Chemokine-Like Protein TAFA-5 3 4
  • TAFA5 3 4
  • Protein FAM19A5 3
  • TAFA Protein 5 3
  • QLLK5208 3
  • UNQ5208 3
  • TAFA-5 3

External Ids for FAM19A5 Gene

Previous GeneCards Identifiers for FAM19A5 Gene

  • GC22P047206
  • GC22P047428
  • GC22P048885
  • GC22P031967

Summaries for FAM19A5 Gene

Entrez Gene Summary for FAM19A5 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]

GeneCards Summary for FAM19A5 Gene

FAM19A5 (Family With Sequence Similarity 19 Member A5, C-C Motif Chemokine Like) is a Protein Coding gene. An important paralog of this gene is FAM19A4.

Gene Wiki entry for FAM19A5 Gene

Additional gene information for FAM19A5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A5 Gene

Genomics for FAM19A5 Gene

GeneHancer (GH) Regulatory Elements for FAM19A5 Gene

Promoters and enhancers for FAM19A5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J048489 Promoter 0.7 Ensembl 650.7 +0.3 341 0.4 MXI1 ZFX FAM19A5 LOC284933
GH22J048492 Promoter 0.5 EPDnew 650.7 +0.1 74 0.1 FAM19A5 LOC284933
GH22J048488 Enhancer 0.4 FANTOM5 657.1 -1.2 -1171 0.3 CTCF FAM19A5 ENSG00000233179
GH22J048490 Enhancer 0.4 FANTOM5 653.8 +1.4 1435 0.7 ELF1 FAM19A5 LOC284933
GH22J048491 Enhancer 0.3 ENCODE 650.7 -0.2 -196 0.2 CTCF FAM19A5 ENSG00000233179
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM19A5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM19A5 gene promoter:
  • Egr-1
  • Pax-5
  • GATA-6
  • STAT3
  • AML1a
  • FOXO4
  • c-Myb

Genomic Locations for FAM19A5 Gene

Genomic Locations for FAM19A5 Gene
361,453 bases
Plus strand
361,453 bases
Plus strand

Genomic View for FAM19A5 Gene

Genes around FAM19A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A5 Gene

Proteins for FAM19A5 Gene

  • Protein details for FAM19A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM19A5
    Protein Accession:
    Secondary Accessions:
    • A6NII9
    • B0QZ13
    • B0QZ14
    • B0QZ15
    • O95902
    • Q5H9C4
    • Q6UWC9
    • Q8IXR8

    Protein attributes for FAM19A5 Gene

    132 amino acids
    Molecular mass:
    14301 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD20061.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH39396.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM19A5 Gene


neXtProt entry for FAM19A5 Gene

Post-translational modifications for FAM19A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM19A5 Gene

No data available for DME Specific Peptides for FAM19A5 Gene

Domains & Families for FAM19A5 Gene

Gene Families for FAM19A5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FAM19A5 Gene


Suggested Antigen Peptide Sequences for FAM19A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM19/TAFA family.
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A5: view

Function for FAM19A5 Gene

Phenotypes From GWAS Catalog for FAM19A5 Gene

Phenotypes for FAM19A5 Gene

genes like me logo Genes that share phenotypes with FAM19A5: view

Animal Model Products

miRNA for FAM19A5 Gene

miRTarBase miRNAs that target FAM19A5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A5 Gene

Localization for FAM19A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A5 Gene

Membrane; Single-pass membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM19A5 gene
Compartment Confidence
extracellular 5
plasma membrane 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FAM19A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM19A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM19A5 Gene

Pathways & Interactions for FAM19A5 Gene

SuperPathways for FAM19A5 Gene

No Data Available

Interacting Proteins for FAM19A5 Gene

Gene Ontology (GO) - Biological Process for FAM19A5 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM19A5 Gene

Drugs & Compounds for FAM19A5 Gene

No Compound Related Data Available

Transcripts for FAM19A5 Gene

mRNA/cDNA for FAM19A5 Gene

Unigene Clusters for FAM19A5 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A5 Gene

No ASD Table

Relevant External Links for FAM19A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM19A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM19A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM19A5 Gene

This gene is overexpressed in Bone (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM19A5 Gene

Protein tissue co-expression partners for FAM19A5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM19A5 Gene:


SOURCE GeneReport for Unigene cluster for FAM19A5 Gene:


mRNA Expression by UniProt/SwissProt for FAM19A5 Gene:

Tissue specificity: Isoform 2 is brain-specific.

Evidence on tissue expression from TISSUES for FAM19A5 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with FAM19A5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM19A5 Gene

Orthologs for FAM19A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM19A5 34
  • 100 (a)
(Bos Taurus)
Mammalia FAM19A5 34 33
  • 93.27 (n)
(Mus musculus)
Mammalia Fam19a5 16 34 33
  • 92.68 (n)
(Rattus norvegicus)
Mammalia Fam19a5 33
  • 92.68 (n)
(Canis familiaris)
Mammalia FAM19A5 34 33
  • 90.78 (n)
(Ornithorhynchus anatinus)
Mammalia FAM19A5 34
  • 59 (a)
(Gallus gallus)
Aves FAM19A5 34
  • 67 (a)
(Anolis carolinensis)
Reptilia FAM19A5 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12555 33
(Danio rerio)
Actinopterygii fam19a5 34
  • 65 (a)
Species where no ortholog for FAM19A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A5 Gene

Gene Tree for FAM19A5 (if available)
Gene Tree for FAM19A5 (if available)
Evolutionary constrained regions (ECRs) for FAM19A5: view image

Paralogs for FAM19A5 Gene

Paralogs for FAM19A5 Gene

(4) SIMAP similar genes for FAM19A5 Gene using alignment to 2 proteins:

  • F19A5_HUMAN
  • B1B1J6_HUMAN
genes like me logo Genes that share paralogs with FAM19A5: view

Variants for FAM19A5 Gene

Sequence variations from dbSNP and Humsavar for FAM19A5 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000004469 -- 48,750,379(+) G/A 3_prime_UTR_variant
rs1000006625 -- 48,676,714(+) G/A intron_variant
rs1000017660 -- 48,676,018(+) G/A intron_variant
rs1000020703 -- 48,575,930(+) GGCGGCGGAGGAGGCGGCGGCGG/GGCGGCGGAGGAGGCGGCGGCGGAGGAGGCGGCGGCGG genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000024092 -- 48,555,936(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A5 Gene

Variant ID Type Subtype PubMed ID
dgv1330e212 CNV loss 25503493
dgv2476n106 CNV deletion 24896259
dgv2629e59 CNV duplication 20981092
dgv747e201 CNV deletion 23290073
dgv778n67 CNV gain 20364138
dgv779n67 CNV gain 20364138
dgv8126n54 CNV loss 21841781
dgv8127n54 CNV gain+loss 21841781
dgv8128n54 CNV gain 21841781
dgv8129n54 CNV loss 21841781
dgv8130n54 CNV loss 21841781
esv1005087 CNV loss 20482838
esv1138502 CNV insertion 17803354
esv1166452 CNV insertion 17803354
esv1337416 CNV deletion 17803354
esv1418211 CNV insertion 17803354
esv1705117 CNV deletion 17803354
esv1984946 CNV deletion 18987734
esv2149667 CNV deletion 18987734
esv22451 CNV gain 19812545
esv2250197 CNV deletion 18987734
esv2300898 CNV deletion 18987734
esv2358153 CNV deletion 18987734
esv2462207 CNV deletion 19546169
esv24783 CNV gain 19812545
esv2538802 CNV deletion 19546169
esv2619129 CNV insertion 19546169
esv2661095 CNV deletion 23128226
esv2663229 CNV deletion 23128226
esv2666627 CNV deletion 23128226
esv2673355 CNV deletion 23128226
esv2675054 CNV deletion 23128226
esv2724546 CNV deletion 23290073
esv2724547 CNV deletion 23290073
esv2724548 CNV deletion 23290073
esv2724549 CNV deletion 23290073
esv2724551 CNV deletion 23290073
esv2724552 CNV deletion 23290073
esv2724553 CNV deletion 23290073
esv2724554 CNV deletion 23290073
esv2724555 CNV deletion 23290073
esv2724556 CNV deletion 23290073
esv2724557 CNV deletion 23290073
esv2724558 CNV deletion 23290073
esv2724559 CNV deletion 23290073
esv2724560 CNV deletion 23290073
esv2724562 CNV deletion 23290073
esv2724564 CNV deletion 23290073
esv275178 CNV loss 21479260
esv2758849 CNV gain+loss 17122850
esv28019 CNV loss 19812545
esv28096 CNV loss 19812545
esv29647 CNV loss 19812545
esv29827 CNV loss 19812545
esv3024901 CNV deletion 24192839
esv3026012 CNV deletion 24192839
esv3310580 CNV novel sequence insertion 20981092
esv3360674 CNV duplication 20981092
esv3385293 CNV duplication 20981092
esv3558306 CNV deletion 23714750
esv3558309 CNV deletion 23714750
esv3558311 CNV deletion 23714750
esv3568469 CNV loss 25503493
esv3568473 CNV loss 25503493
esv3568474 CNV loss 25503493
esv3568475 CNV loss 25503493
esv3648019 CNV loss 21293372
esv3648020 CNV loss 21293372
esv3648021 CNV loss 21293372
esv3893493 CNV loss 25118596
esv3974 CNV loss 18987735
esv6768 CNV loss 19470904
esv993242 CNV deletion 20482838
esv996738 CNV deletion 20482838
esv997814 CNV insertion 20482838
esv998435 CNV deletion 20482838
nsv1056408 CNV gain 25217958
nsv1057928 CNV loss 25217958
nsv1059281 CNV loss 25217958
nsv1062235 CNV gain 25217958
nsv1064218 CNV gain 25217958
nsv1065806 CNV gain 25217958
nsv1072223 CNV deletion 25765185
nsv1073173 CNV deletion 25765185
nsv1073174 CNV deletion 25765185
nsv1073186 CNV deletion 25765185
nsv1111607 CNV deletion 24896259
nsv1115637 CNV duplication 24896259
nsv1120798 CNV deletion 24896259
nsv1133546 CNV deletion 24896259
nsv1133547 CNV deletion 24896259
nsv1135579 CNV deletion 24896259
nsv1135912 CNV deletion 24896259
nsv1135913 CNV deletion 24896259
nsv1144033 CNV deletion 24896259
nsv1144034 CNV deletion 24896259
nsv1144035 CNV deletion 24896259
nsv1149439 CNV deletion 26484159
nsv1151989 CNV duplication 26484159
nsv1152016 CNV deletion 26484159
nsv1153092 CNV deletion 26484159
nsv191479 CNV deletion 16902084
nsv3660 CNV insertion 18451855
nsv459914 CNV loss 19166990
nsv459915 CNV loss 19166990
nsv473732 CNV novel sequence insertion 20440878
nsv474662 CNV novel sequence insertion 20440878
nsv474714 CNV novel sequence insertion 20440878
nsv476522 CNV novel sequence insertion 20440878
nsv477032 CNV novel sequence insertion 20440878
nsv478798 CNV novel sequence insertion 20440878
nsv480961 CNV novel sequence insertion 20440878
nsv512662 CNV loss 21212237
nsv513596 CNV insertion 21212237
nsv521221 CNV loss 19592680
nsv524377 CNV loss 19592680
nsv589147 CNV gain 21841781
nsv589149 CNV loss 21841781
nsv589159 CNV gain 21841781
nsv589160 CNV gain 21841781
nsv589162 CNV loss 21841781
nsv589163 CNV gain 21841781
nsv818005 CNV loss 17921354
nsv820625 CNV deletion 20802225
nsv829304 CNV gain 20364138
nsv829305 CNV gain 20364138
nsv829310 CNV gain 20364138
nsv829311 CNV gain 20364138
nsv829312 CNV gain 20364138
nsv829313 CNV gain 20364138
nsv829315 CNV gain 20364138
nsv829316 CNV gain 20364138
nsv829317 CNV gain 20364138
nsv829318 CNV gain 20364138
nsv829320 CNV gain 20364138
nsv834232 CNV loss 17160897
nsv955186 CNV deletion 24416366
nsv955187 CNV deletion 24416366

Variation tolerance for FAM19A5 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM19A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A5 Gene

Disorders for FAM19A5 Gene

Additional Disease Information for FAM19A5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM19A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM19A5 Gene

Publications for FAM19A5 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y … Rupp F (Genomics 2004) 2 3 4 58
  2. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. (PMID: 22158540) Wu C … Lin D (Nature genetics 2011) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The putative neuropeptide TAFA5 is expressed in the hypothalamic paraventricular nucleus and is regulated by dehydration. (PMID: 18275939) Paulsen SJ … Larsen LK (Brain research 2008) 2 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FAM19A5 Gene

Sources for FAM19A5 Gene

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