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Aliases for FAM19A4 Gene

Aliases for FAM19A4 Gene

  • Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like 2 3 5
  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A4 2 3
  • Chemokine-Like Protein TAFA-4 3 4
  • TAFA4 3 4
  • Protein FAM19A4 3
  • TAFA-4 3

External Ids for FAM19A4 Gene

Previous GeneCards Identifiers for FAM19A4 Gene

  • GC03M068864

Summaries for FAM19A4 Gene

Entrez Gene Summary for FAM19A4 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM19A4 Gene

FAM19A4 (Family With Sequence Similarity 19 Member A4, C-C Motif Chemokine Like) is a Protein Coding gene. An important paralog of this gene is FAM19A2.

Additional gene information for FAM19A4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A4 Gene

Genomics for FAM19A4 Gene

GeneHancer (GH) Regulatory Elements for FAM19A4 Gene

Promoters and enhancers for FAM19A4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I068932 Promoter/Enhancer 1.3 EPDnew ENCODE 550.3 +20.7 20663 0.7 ZSCAN5A ELF3 GTF2F1 CTCF MXI1 USF1 ZNF777 SAP130 MLX ARID4B FAM19A4 RNA5SP135
GH03I068894 Promoter 0.6 EPDnew 560.7 +58.6 58605 0.1 ZFP36 FAM19A4 RNA5SP135
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM19A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM19A4 gene promoter:

Genomic Locations for FAM19A4 Gene

Genomic Locations for FAM19A4 Gene
221,534 bases
Minus strand

Genomic View for FAM19A4 Gene

Genes around FAM19A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A4 Gene

Proteins for FAM19A4 Gene

  • Protein details for FAM19A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM19A4
    Protein Accession:
    Secondary Accessions:
    • A8MVT2

    Protein attributes for FAM19A4 Gene

    140 amino acids
    Molecular mass:
    15682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM19A4 Gene

Post-translational modifications for FAM19A4 Gene

No Post-translational modifications

Other Protein References for FAM19A4 Gene

No data available for DME Specific Peptides for FAM19A4 Gene

Domains & Families for FAM19A4 Gene

Gene Families for FAM19A4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FAM19A4 Gene


Suggested Antigen Peptide Sequences for FAM19A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM19/TAFA family.
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A4: view

Function for FAM19A4 Gene

Phenotypes From GWAS Catalog for FAM19A4 Gene

Gene Ontology (GO) - Molecular Function for FAM19A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM19A4: view

Phenotypes for FAM19A4 Gene

GenomeRNAi human phenotypes for FAM19A4:
genes like me logo Genes that share phenotypes with FAM19A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM19A4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM19A4 Gene

Localization for FAM19A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM19A4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for FAM19A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM19A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM19A4 Gene

Pathways & Interactions for FAM19A4 Gene

SuperPathways for FAM19A4 Gene

No Data Available

Interacting Proteins for FAM19A4 Gene

Selected Interacting proteins: Q96LR4-F19A4_HUMAN for FAM19A4 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for FAM19A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042391 regulation of membrane potential IEA --
GO:0051930 regulation of sensory perception of pain IEA --
genes like me logo Genes that share ontologies with FAM19A4: view

No data available for Pathways by source and SIGNOR curated interactions for FAM19A4 Gene

Drugs & Compounds for FAM19A4 Gene

No Compound Related Data Available

Transcripts for FAM19A4 Gene

mRNA/cDNA for FAM19A4 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM19A4 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for FAM19A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM19A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM19A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x9.4), Adrenal Gland (x6.7), Brain - Substantia nigra (x5.5), and Stomach (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of FAM19A4 Gene:


SOURCE GeneReport for Unigene cluster for FAM19A4 Gene:


mRNA Expression by UniProt/SwissProt for FAM19A4 Gene:

Tissue specificity: Brain-specific.

Evidence on tissue expression from TISSUES for FAM19A4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with FAM19A4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM19A4 Gene

Orthologs for FAM19A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM19A4 33 34
  • 100 (n)
(Bos Taurus)
Mammalia FAM19A4 34
  • 93 (a)
(Canis familiaris)
Mammalia FAM19A4 33 34
  • 92.38 (n)
(Mus musculus)
Mammalia Fam19a4 33 16 34
  • 88.4 (n)
(Rattus norvegicus)
Mammalia Fam19a4 33
  • 88.15 (n)
(Ornithorhynchus anatinus)
Mammalia FAM19A4 34
  • 82 (a)
(Monodelphis domestica)
Mammalia FAM19A4 34
  • 78 (a)
(Gallus gallus)
Aves FAM19A4 33 34
  • 82.97 (n)
(Anolis carolinensis)
Reptilia FAM19A4 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a4 33
  • 76.81 (n)
(Danio rerio)
Actinopterygii fam19a4b 33 34
  • 71.31 (n)
Species where no ortholog for FAM19A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A4 Gene

Gene Tree for FAM19A4 (if available)
Gene Tree for FAM19A4 (if available)

Paralogs for FAM19A4 Gene

Paralogs for FAM19A4 Gene

(4) SIMAP similar genes for FAM19A4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM19A4: view

Variants for FAM19A4 Gene

Sequence variations from dbSNP and Humsavar for FAM19A4 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000006418 -- 68,761,396(-) C/T intron_variant
rs1000043438 -- 68,900,217(-) G/A intron_variant
rs1000051329 -- 68,789,833(-) A/G intron_variant
rs1000053790 -- 68,831,802(-) A/C intron_variant
rs1000067759 -- 68,931,446(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A4 Gene

Variant ID Type Subtype PubMed ID
dgv2533n106 CNV deletion 24896259
dgv2534n106 CNV deletion 24896259
esv1011141 CNV insertion 20482838
esv1734354 CNV deletion 17803354
esv2141895 CNV deletion 18987734
esv2504953 CNV deletion 19546169
esv2658323 CNV deletion 23128226
esv2678597 CNV deletion 23128226
esv2725381 CNV deletion 23290073
esv2725382 CNV deletion 23290073
esv2759156 CNV gain 17122850
esv2762332 CNV loss 21179565
esv3305888 CNV mobile element insertion 20981092
esv3357082 CNV insertion 20981092
esv3358 CNV loss 18987735
esv3562029 CNV deletion 23714750
esv3562030 CNV deletion 23714750
esv3568839 CNV loss 25503493
esv3596488 CNV loss 21293372
esv8699 CNV loss 19470904
esv989471 CNV deletion 20482838
nsv1003221 CNV loss 25217958
nsv1014265 CNV loss 25217958
nsv1126151 CNV deletion 24896259
nsv1151466 CNV deletion 26484159
nsv1151544 CNV deletion 26484159
nsv1160944 CNV duplication 26073780
nsv236602 CNV deletion 16902084
nsv525701 CNV gain 19592680
nsv834722 CNV gain 17160897
nsv956303 CNV deletion 24416366

Variation tolerance for FAM19A4 Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM19A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A4 Gene

Disorders for FAM19A4 Gene

Additional Disease Information for FAM19A4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM19A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM19A4 Gene

Publications for FAM19A4 Gene

  1. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y … Rupp F (Genomics 2004) 2 3 4 58
  2. FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. (PMID: 25109685) Wang W … Han W (Cellular & molecular immunology 2015) 2 3 58
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for FAM19A4 Gene

Sources for FAM19A4 Gene

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